Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 3030-3049 av 3426
-
Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer
(Peer reviewed; Journal article, 2020)Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification ... -
Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts
(Peer reviewed; Journal article, 2022)Objective Bisphosphonates like alendronate mainly exert their effects on osteoclasts. However, osteoblasts are also affected, but exposed to a much lower concentration in vivo than the osteoclasts. Given that the effects ... -
Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells
(Master thesis, 2019)Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ... -
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
(Peer reviewed; Journal article, 2020)Abstract Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies ... -
Targeting phosphoglycerate dehydrogenase in multiple myeloma
(Peer reviewed; Journal article, 2021)Background: Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required. ... -
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells
(Journal article; Peer reviewed, 2013)Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ... -
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
(Journal article, 2019)Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling ... -
Targeting translesion synthesis by inhibiting protein interactions of the DNA sliding clamps
(Doctoral theses at NTNU;2019:354, Doctoral thesis, 2019) -
Tarmfloraen - på helsa løs
(Journal article, 2015) -
Teacher-student approach for lung tumor segmentation from mixed-supervised datasets
(Journal article; Peer reviewed, 2022)Purpose Cancer is among the leading causes of death in the developed world, and lung cancer is the most lethal type. Early detection is crucial for better prognosis, but can be resource intensive to achieve. Automating ... -
Teambasert læring - en studentaktiviserende og lærerstyrt undervisningsform
(Journal article; Peer reviewed, 2017)Bakgrunn: Studentaktiviserende undervisning er viktig for å oppnå god læring. I teambasert læring (TBL) aktiviseres studentene individuelt, gruppevis og i plenum under ledelse av faglærer. TBL er i liten grad prøvd ut og ... -
Technologies for assessment of bone reflecting bone strength and bone mineral density in elderly women: An update
(Peer reviewed; Journal article, 2016)Reduced bone mineral density is a strong risk factor for fracture. The WHO’s definition of osteoporosis is based on bone mineral density measurements assessed by dual x-ray absorptiometry. Several on other techniques than ... -
Temporal quantitative phosphoproteomics profiling of Inter-leukin-33 signaling network reveals unique modulators of monocyte activation
(Peer reviewed; Journal article, 2022)Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses. ... -
Test retest reliability of computer-based video analysis for the assessment of postural control in individuals with cerebral palsy
(Master thesis, 2017)BACKGROUND: Deficits in the control of posture is an important aspect of CP, as defined by SCPE and children with CP often exhibit activity limitations that are associated with postural control problems. However, there is ... -
Test-retest reliability of a novel method for trunk position sense measurement in older adults with and without hyperkyphosis
(Peer reviewed; Journal article, 2023)Introduction: Although the importance of trunk position sense as a clinical outcome measure related to spinal alignment has been established, there is no study evaluating the reliability of measurement techniques for trunk ... -
Test-retest reliability of the patient activation measure-13 in adults with substance use disorders and schizophrenia spectrum disorders
(Peer reviewed; Journal article, 2021)Patient Activation Measure-13 (PAM-13) is a valid and widely used questionnaire that assess an individual’s knowledge, confidence, and skills for self-management of their chronic illness. Although there is some evidence ... -
Test-retest reliability of the Test of Infant Motor Performance Screening Items in infants at risk for impaired functional motor performance
(Peer reviewed; Journal article, 2016)Objective To examine test–retest reliability of the TIMPSI in infants at risk for impaired functional motor performance. Methods The TIMPSI was administered twice to 51 infants from two different hospitals in ... -
Testicular cancer in the cisplatin era: Causes of death and mortality rates in a population-based cohort
(Peer reviewed; Journal article, 2021)PURPOSE Using complete information regarding testicular cancer (TC) treatment burden, this study aimed to investigate cause-specific non-TC mortality with impact on previous treatment with platinum-based chemotherapy (PBCT) ... -
Testing for effects of nicotine on mitochondrial and other functional parameters in insulin-producing ß-cells
(Master thesis, 2020)Bakgrunn: β-celler inneholder nikotinergiske respetorer, men deres funksjon og potensiell betydning når det kommer til diabetes er imidlertidig ikke fullstendig belyst. Nikotin er det mest aktive stoffet i tobakk og røyking ... -
Testing the flexibility of mitochondrial functioning in insulin-producing β-cells under diabetes like conditions in vitro
(Master thesis, 2019)Bakgrunn: Kronisk hyperglykemi er skadelig for de insulinproduserende β-cellene i pankreas. Mitokondrienes funksjon i disse cellene er helt essensiell for at β-cellene skal fungere optimalt. Mitokondriene påvirkes trolig ...