Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 2762-2781 av 3426

    • Risk-taking behavior of adolescents and young adults born preterm 

      Alenius, Suvi; Kajantie, Eero Olavi; Sund, Reijo; Nurhonen, Markku; Haaramo, Peija; Näsänen-Gilmore, Pieta; Vääräsmäki, Marja; Lemola, Sakari; Räikkönen, Katri; Schnitzlein, Daniel D.; Wolke, Dieter; Gissler, Mika; Hovi, Petteri (Peer reviewed; Journal article, 2023)
      Objectives To study sexually transmitted Chlamydia trachomatis infections (STCTs), teenage pregnancies, and payment defaults in individuals born preterm as proxies for engaging in risk-taking behavior. Study design Our ...

    • Ritualer ved sykdom og død 

      Røen, Ingebrigt; Hirsch, Anne (Chapter, 2016)

    • RNA in DNA repair 

      Vågbø, Cathrine Broberg; Slupphaug, Geir (Peer reviewed; Journal article, 2020)
      Our genome is constantly subject to damage from exogenous and endogenous sources, and cells respond to such damage by initiating a DNA damage response (DDR). Failure to induce an adequate DDR can result in increased mutation ...

    • RNA metabolism guided by RNA modifications: The role of SMUG1 in rRNA quality control 

      Lirussi, Lisa; Demir, Özlem; You, Panpan; Sarno, Antonio; Amaro, Rommie E.; Nilsen, Hilde (Peer reviewed; Journal article, 2021)
      RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified ...

    • RNA motif discovery: a computational overview 

      Achar, Avinash; Sætrom, Pål (Journal article; Peer reviewed, 2015)
      Genomic studies have greatly expanded our knowledge of structural non-coding RNAs (ncRNAs). These RNAs fold into characteristic secondary structures and perform specific-structure dependent biological functions. Hence RNA ...

    • RNA-Integrity and 8-Isoprostane Levels Are Stable in Prostate Tissue Samples Upon Long-Term Storage at −80°C 

      Dybos, Sandra Amalie; Winje Brustad, Åge; Rolfseng, Toril F.Langvik; Kvam, Solveig; Olsen, Oddrun Elise; Halgunset, Jostein; Skogseth, Haakon (Peer reviewed; Journal article, 2020)
      Sampling of prostate tissue (n = 97) was performed in conjunction with planned radical prostatectomies, in collaboration with Biobank1®. The tissue used in this study was collected during the period 2003-2016, quickly ...

    • Robust Distance Measures for kNN Classification of Cancer Data 

      Ehsani, Rezvan; Drabløs, Finn (Peer reviewed; Journal article, 2020)
      The k-Nearest Neighbor (kNN) classifier represents a simple and very general approach to classification. Still, the performance of kNN classifiers can often compete with more complex machine-learning algorithms. The core ...

    • Robust DNA repair in PAXX-deficient mammalian cells 

      Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ...

    • Robustness of VMAT and 3DCRT plans toward setup errors in radiation therapy of locally advanced left-sided breast cancer with DIBH 

      Jensen, Christer André; Roa, Ana María Acosta; Johansen, Marie; Lund, Jo-Åsmund; Frengen, Jomar (Journal article; Peer reviewed, 2018)
      Purpose The aim of our study was to evaluate and compare the robustness of treatment plans produced using the volumetric modulated arc-therapy (VMAT) and the standard three-dimensional conformal radiotherapy (3DCRT) ...

    • A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres 

      Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia; Garbelli, Anna; Maffia, Antonio; Bione, Silvia; Ferrari, Elena; d'Adda di Fagagna, Fabrizio; Francia, Sofia; Sabbioneda, Simone; Chen, Liuh-Yow; Lingner, Joachim; Bergoglio, Valerie; Hoffmann, Jean-Sebastien; Hübscher, Ulrich; Crespan, Emmanuele; Maga, Giovanni (Peer reviewed; Journal article, 2021)
      Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and ...

    • A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis 

      Sikkeland, Liv Ingunn Bjoner; Ueland, Thor; Samersaw-Lund, May Brit; Durheim, Michael Thomas; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2023)
      Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by damage to the alveolar epithelium, leading to fibrosis and excessive accumulation of extracellular matrix in the ...

    • The role of Alkyladenine DNA glycosylase (AAG) beyond canonical base excision repair 

      Brambilla, Alessandro (Doctoral theses at NTNU;2021:256, Doctoral thesis, 2021)

    • The role of alkylation stress response in anticancer drug resistance 

      Roliński, Miłosz (Doctoral theses at NTNU;2020:114, Doctoral thesis, 2020)

    • Role of APIM in the NF-κB signaling network 

      Jacob, Havjin (Master thesis, 2011)
      Decades of research have revealed that the nuclear factor-κB (NF-κB) is an important functional transcription factor which lately is also found to be constitutively active in many cancer cells such as multiple myeloma cell ...

    • Role of Autoimmune Gastritis in Gastric Cancer 

      Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2019)
      It has been known for 70 years that gastric cancer occurs mainly in a stomach with gastritis. Gastritis was previously so prevalent that it was regarded as an aging phenomenon. Since the description of Helicobacter pylori ...

    • Role of autoimmunity and over stimulationfor ß-cell deficiency: Epidemiological and therapeutic perspectives 

      Radtke, Maria Anita (Doktoravhandlinger ved NTNU, 1503-8181; 2009:221, Doctoral thesis, 2009)
      Betydningen av diabetesantistoff og β-cellehvile for insulinproduksjonen. Diabetes omfatter flere sykdomsgrupper. Type 1 diabetes er en autoimmun sykdom, dvs. antistoff bryter ned de insulinproduserende cellene (β-cellene). ...

    • Role of CD5L in control of human innate immune function 

      Moharrami, Neda Nejati (Doctoral theses at NTNU;2018:395, Doctoral thesis, 2018)
      Innate immune signaling has numerous ways to sense changes in cellular metabolism to ensure appropriate response to threatening agents. For instance, cholesterol metabolites act as ligands for nuclear receptor transcription ...

    • Role of enteropathogenic Escherichia coli in childhood diarrhoea in Norway 

      Afset, Jan Egil (Doktoravhandlinger ved NTNU, 1503-8181; 2007:260, Doctoral thesis, 2007)
      Background Diarrhoeal diseases are among the leading causes of illness and death among children in developing countries, and do also cause considerable morbidity in industrialized countries. Enteropathogenic E. coli (EPEC), ...

    • Role of Esx-3 Secretion System and Stress Response in Mycobacteria smegmatis 

      Derese Siyum, Yohannes (Master thesis, 2015)
      Background: Bacteria secrets proteins to manipulate their growth environments through various secretion systems. Type VII systems are important protein secretary systems known in mycobacteria. 5 different Type VII systems ...

    • Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort 

      Grønseth, Stine; Rogne, Tormod; Heggelund, Lars; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Peer reviewed; Journal article, 2023)
      Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ...