Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 27-46 av 3426
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A method to assess obstetric outcomes using the 10-Group Classification System: A quantitative descriptive study
(Journal article; Peer reviewed, 2017)Objectives Internationally, the 10-Group Classification System (TGCS) has been used to report caesarean section rates, but analysis of other outcomes is also recommended. We now aim to present the TGCS as a method to assess ... -
A new approach to the study of middle cerebral artery occlusion in the rat using magnetic resonance techniques
(Dissertations at the Faculty of Medicine, 0805-7680; 200, Doctoral thesis, 2001) -
A novel antimycobacterial compound acts as an intracellular iron chelator
(Journal article; Peer reviewed, 2015)Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations ... -
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
(Journal article; Peer reviewed, 2011)Recently, 5-hydroxymethylcytosine (5hmC) was identified in mammalian genomic DNA. The biological role of this modification remains unclear; however, identifying the genomic location of this modified base will assist in ... -
A novel non-canonical Wnt signature for prostate cancer aggressiveness
(Journal article; Peer reviewed, 2016)Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ... -
A Novel Photosensitizer for PET-Imaging and Cancer Treatment —In vitro studies (AY-27 cells)
(Master thesis, 2021) -
A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells
(Journal article; Peer reviewed, 2019)Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections ... -
A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer.
(Journal article; Peer reviewed, 2016)Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ... -
A Preoperative Multimarker Approach to Evaluate Acute Kidney Injury After Cardiac Surgery.
(Journal article; Peer reviewed, 2016)Objective To investigate whether a multimarker strategy combining preoperative biomarkers representing distinct pathophysiologic pathways enhances preoperative risk assessment of acute kidney injury after cardiac surgery ... -
A property-based analysis of human transcription factors
(Journal article; Peer reviewed, 2015)Background Transcription factors are essential proteins for regulating gene expression. This regulation depends upon specific features of the transcription factors, including how they interact with DNA, how they interact ... -
A prospective study examining cachexia predictors in patients with incurable cancer
(Journal article; Peer reviewed, 2019)Background Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based ... -
A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer
(Journal article; Peer reviewed, 2017)Background: Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, and decreased physical function. It has been suggested that the optimal treatment for cachexia should be a multimodal intervention. ... -
A reliability study of the rapid emergency triage and treatment system for children
(Journal article; Peer reviewed, 2016-02-24)Background To evaluate inter- and intrarater reliability of a new Scandinavian triage system for children, the Rapid Emergency Triage and Treatment System-pediatric (RETTS-p). Methods Two observational studies ... -
A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach
(Journal article; Peer reviewed, 2017)Introduction Patients with diabetes type 1 (DM1) struggle daily to achieve good glucose control. The last decade has seen a rush of research groups working towards an artificial pancreas (AP) through the application of a ... -
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
(Journal article; Peer reviewed, 2015)Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ... -
A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34(+) cells
(Journal article; Peer reviewed, 2013)Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement ... -
A study of the transcriptional repressor ICER: Regulatory networks in gastrin-induced gene expression
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:117, Doctoral thesis, 2009)En studie av transkripsjonsrepressoren ICER. Regulatoriske nettverk i gastrin-indusert genuttrykk. Nar et hormon eller en vekstfaktor binder til spesifikke mottagere pa celleoverflaten, vil dette fore til en intracellular ... -
A Study of Toll-like Receptors in Trophoblasts, and the Influence of Cytomegalovirus Infection
(Master thesis, 2012)Toll-like receptors (TLRs) act as sensors against invading pathogens and endogenous danger signals, and are critical mediators of inflammatory immune responses. During pregnancy, intrauterine activation of TLRs might evoke ... -
A Study of Urothelial Carcinoma: Gene Expression Profiling, Tumorigenesis and Therapies in Orthotopic Animal Models
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:27, Doctoral thesis, 2011)En studie om urothelial karsinom: Genekspresjonsprofilering, tumorutvikling og terapi i ortotopiskiske dyremodeller. Urinblærekreft er en hyppig forekommende kreftform som i noen tilfeller har dårlig prognose. Dette arbeide ... -
A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis
(Journal article; Peer reviewed, 2017)Background Maternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between ...