Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2570-2589 av 3426
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Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells
(Peer reviewed; Journal article, 2023)Photochemical internalization (PCI) is a promising new technology for site-specific drug delivery, developed from photodynamic therapy (PDT). In PCI, light-induced activation of a photosensitizer trapped inside endosomes ... -
Proteomic approaches to improve cancer therapy – Identifying factors contributing to melphalan resistance in multiple myeloma and to PDT mediated cytotoxicity
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:147, Doctoral thesis, 2014) -
The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function
(Peer reviewed; Journal article, 2020)CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ... -
Proteomics Analysis of Proteins Involved in DNA Base Repair and Cancer Therapy
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:72, Doctoral thesis, 2012)Proteomikkbasert analyse av proteiner involvert i DNA reparasjon og kreftbehandling DNA reparasjon er grunnleggende for å opprettholdelse levende organismers genom. Forskning i løpet av det siste tiåret har vesentlig økt ... -
Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
(Peer reviewed; Journal article, 2024)Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs ... -
Proton pump inhibitors and fracture risk. The HUNT study, Norway.
(Journal article; Peer reviewed, 2019)Summary Proton pump inhibitors (PPIs) have been linked to increased risk of fracture; the data have, however, been diverging. We did not find any increased risk of fractures among users of PPIs in a Norwegian population ... -
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities
(Journal article; Peer reviewed, 2014)The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno ... -
Pseudo-anaphylaxis to polyethylene glycol (PEG)-coated liposomes: Roles of anti-PEG IgM and complement activation in a porcine model of human infusion reactions
(Journal article; Peer reviewed, 2019)Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier ... -
Pseudo-T2 mapping for normalization of T2-weighted prostate MRI
(Peer reviewed; Journal article, 2022)Objective Signal intensity normalization is necessary to reduce heterogeneity in T2-weighted (T2W) magnetic resonance imaging (MRI) for quantitative analysis of multicenter data. AutoRef is an automated dual-reference ... -
Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study
(Journal article; Peer reviewed, 2017)Background To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA). Methods In ... -
Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates
(Journal article; Peer reviewed, 2015)Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed ... -
Psychiatric Disorders and General Functioning in Low Birthweight Adults: A Longitudinal Study
(Journal article; Peer reviewed, 2017)OBJECTIVE: To examine psychiatric morbidity and overall functioning in adults born with low birth weight compared with normal birth weight controls at age 26 years and to study longitudinal trajectories of psychiatric ... -
Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis
(Peer reviewed; Journal article, 2021)Background Data on psychiatric disorders in survivors born very preterm (VP; <32 weeks) or very low birthweight (VLBW; <1500 g) are sparse. We compared rates of psychiatric diagnoses between VP/VLBW and term-born, normal ... -
Psychiatric morbidity, somatic comorbidity and substance use in an adolescent psychiatric population at 3-year follow-up
(Peer reviewed; Journal article, 2020)Knowledge is scarce on the course of psychiatric disorders in adolescence. We aimed to assess changes in the frequency of psychiatric disorders, somatic disorders, pain, and substance use in a clinical psychiatric cohort ... -
Psychiatric Symptoms and Risk Factors in Adults Born Preterm with Very Low Birthweight or Born Small for Gestational Age at Term
(Journal article; Peer reviewed, 2019)Background We aimed to examine psychiatric symptoms in adults born preterm with very low birthweight or born at term small for gestational age compared with normal birthweight peers, and examine associations with perinatal ... -
Psychomotor skills assessment by motion analysis in minimally invasive surgery on an animal organ
(Journal article; Peer reviewed, 2017)Background: A high level of psychomotor skills is required to perform minimally invasive surgery (MIS) safely. To be able to measure these skills is important in the assessment of surgeons, as it enables constructive ... -
Psychosocial Vulnerability Among Patients Contacting a Norwegian Sexual Assault Center
(Journal article, 2016)In this study, the objective was to assess the occurrence of specific vulnerability factors among adult and adolescent females attending a Norwegian sexual assault center (SAC). We also explored assault characteristics and ... -
Psykisk helse hos personer med moderat lav IQ
(Master thesis, 2016)Introduksjon: Kognitive funksjoner er definert som funksjoner som har betydning for erkjennelse, tenkning og kunnskapservervelse1. Intelligens er menneskers evne til nettopp det å tenke, oppfatte, forstå og erfare2. IQ ... -
PUFA-induced stress in cancer cells –autophagy as a potential determinant for cell survival
(Master thesis, 2010)Polyunsaturated fatty acids (PUFAs) show diverse effects on cancer cells. The explanation to why some cancer cells seem to be sensitive of PUFAs and some do not is, however, still a debated topic. Autophagy is a disease ...