Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2283-2302 av 3426
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Osimertinib in non-small cell lung cancer with uncommon EGFR-mutations: a post-hoc subgroup analysis with pooled data from two phase II clinical trials
(Peer reviewed; Journal article, 2022)Background: Osimertinib is standard of care for EGFR-mutated non-small cell lung cancer (NSCLC) patients. The efficacy of the drug in patients with mutations other than the common deletion in exon 19 and L858R in exon 21 ... -
Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study)
(Peer reviewed; Journal article, 2020)Objectives In non-small cell lung cancer patients with acquired resistance to first- or second-generation EGFR-TKIs, osimertinib is approved in the presence of the T790 M resistance mutation. We assessed the efficacy of ... -
Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model
(Peer reviewed; Journal article, 2023)In vitro models of primary human osteocytes embedded in natural mineralized matrix without artificial scaffolds are lacking. We have established cell culture conditions that favored the natural 3D orientation of the bone ... -
Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices
(Journal article; Peer reviewed, 2015)Mineralized biomaterials are promising for use in bone tissue engineering. Culturing osteogenic cells in such materials will potentially generate biological bone grafts that may even further augment bone healing. Here, ... -
Osteogenic properties of human mesenchymal stem cells cultured on additively manufactured Ti-6Al-4V samples
(Master thesis, 2020)Annually, hundreds of thousands of hip replacements are performed in the United States alone. This number is expected to increase with an increasing number of motor vehicle accidents and an increasingly active aging ... -
"Out of the box” new therapeutic strategies for Crohn´s disease: moving beyond biologics
(Peer reviewed; Journal article, 2022) -
Outbreak of tularaemia in central Norway, January to March 2011
(Journal article; Peer reviewed, 2011)From January to March 2011, 39 cases of tularaemia were diagnosed in three counties in central Norway: 21 cases of oropharyngeal type, 10 cases of glandular/ulceroglandular type, two of respiratory and two of typhoid type. ... -
Outcome Assessments in Non- Metastatic Prostate Cancer
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:74, Doctoral thesis, 2011)Metoder for å måle utfall av behandling hos pasienter med prostatakreft uten spredning. Prostatakreft uten påvist spredning kan behandles med operasjon, strålebehandling med eller uten hormonbehandling, eller hormonbehandling ... -
Outcome in adolescence of brachial plexus birth palsy - 69 individuals re-examined after 10-20 years
(Peer reviewed; Journal article, 2014)Background and purpose — The frequency and severity of a permanent lesion after brachial plexus birth palsy (BPBP) and its impact on activities of daily living are not well documented. We therefore investigated the outcome ... -
Outcomes After Elective Inguinal Hernia Repair Performed by Associate Clinicians vs Medical Doctors in Sierra Leone: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2021)Importance Task sharing of surgical duties with medical doctors (MDs) without formal surgical training and associate clinicians (ACs; health care workers corresponding to an educational level between that of a nurse and ... -
Outcomes and predictors of functioning, mental health, and health-related quality of life in adults born with very low birth weight: a prospective longitudinal cohort study
(Peer reviewed; Journal article, 2022)Background Very low birth weight (VLBW: ≤1500 g) is associated with multiple short and long-term complications. This study aimed to examine outcomes and predictors of functioning, mental health, and health-related quality ... -
Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction.
(Peer reviewed; Journal article, 2019)Introduction Patients with cancer who develop small bowel obstruction are at high risk of malnutrition and morbidity following compromise of gastrointestinal tract continuity. This study aimed to characterise current ... -
Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit
(Peer reviewed; Journal article, 2020)Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition ... -
Overvekt og fedme i Trøndelag 2019: Helsestatistikk-rapport nummer 11 fra HUNT4
(Research report, 2023) -
Overweight, obesity and related conditions: a cross-sectional study of adult inpatients at a Norwegian Hospital
(Journal article; Peer reviewed, 2014)Background: Overweight, obesity and associated conditions are major public health concerns in Norway. The prevalence of overweight and obesity in the general population in Norway is increasing, but there are limited data ... -
Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study
(Journal article; Peer reviewed, 2018)Aims/hypothesis Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation ... -
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
(Peer reviewed; Journal article, 2020)Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ... -
Oxycodone, Morphine, and Fentanyl in Patients with Chronic Pain: Proposal of Dose-Specific Concentration Ranges
(Peer reviewed; Journal article, 2023)Background: Interpreting opioid concentrations is challenging because of the lack of reference ranges. Therefore, the authors aimed to propose dose-specific concentration ranges in serum for oxycodone, morphine, and ... -
Oxytocin augmentation and its association with labor outcomes
(Doctoral theses at NTNU;2017:163, Doctoral thesis, 2017)Stimulering av rier med oxytocin og sammenheng med fødselsutfall Oxytocin blir ofte brukt under fødselen for å øke styrken på riene. Mangel på klare indikasjoner for bruk av oxytocin har ført til ulik praksis og tilfeldig ... -
Oxytocin treatment in alcohol dependence A double-blind randomized controlled trial
(Doctoral theses at NTNU;2020:168, Doctoral thesis, 2020)Nesespray for alkoholavhengighet? Alkohol er det største rusproblemet i Norge og den nest viktigste risikofaktoren for tap av friske leveår i vår del av verden. Det er medisinske utfordringer knyttet til alkoholavhengighet, ...