Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1587-1606 of 3426
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In situ cofactor regeneration enables selective CO2 reduction in a stable and efficient enzymatic photoelectrochemical cell
(Peer reviewed; Journal article, 2021)Mimicking natural photosynthesis by direct photoelectrochemical (PEC) reduction of CO2 to chemicals and fuels requires complex cell assemblies with limitations in selectivity, efficiency, cost, and stability. Here, we ... -
In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol
(Journal article; Peer reviewed, 2019)Background: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be ... -
In Vitro and In Vivo Biocompatibility Evaluation of Polyallylamine and Macromolecular Heparin Conjugates Modified Alginate Microbeads
(Journal article; Peer reviewed, 2017)Host reactivity to biocompatible immunoisolation devices is a major challenge for cellular therapies, and a human screening model would be of great value. We designed new types of surface modified barium alginate microspheres, ... -
In vitro and in vivo Inhibition of Cytochrome P450 Mediated Metabolism by Chinese Herbal Constituents
(Doctoral thesis, 2016)Herbs have been used for a long time in several traditional practices, particularly in the Asian countries. However, documentation in the context of their safety evaluation is sometimes scarce and the people can consume ... -
In vitro differentiation of osteoclasts - Studying the effect of myeloma derived immunoglobulins on osteoclastogenesis after optimizing the culturing process
(Master thesis, 2016)Multiple myeloma is a hematological cancer caused by accumulation of malignant plasma cells in the bone marrow with extensive bone destruction and heavily decreased bone formation. Osteoclasts are terminally differentiated, ... -
In vitro effects of radiation and mechanical load on murine osteocytes MLO-Y4
(Master thesis, 2020)The increased survival rates for cancer as a result of improved diagnosis and treatment has come with the drawback that cancer treatment side effects are becoming more frequent as well. Cancer treatment induced bone loss ... -
In vitro effects of the AMP-activated protein kinase agonist metformin on murine osteocytes MLO-Y4
(Master thesis, 2020)Osteoporose er en skjelettsykdom som gir økt risiko for beinbrudd. Sykdommen karakteriseres av nedsatt beinkvalitet og lav beinmasse, og er en økende bekymring grunnet en økt aldrende befolkning. Styrketrening er vist å ... -
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
(Peer reviewed; Journal article, 2023)Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic ... -
In vitro Inhibition of CYP3A4 by VitaePro
(Master thesis, 2016)Introduction and aims: There has been an almost exponential growth within the nutritional supplement industry, and along with this, an increasing number of reported interactions between supplements and prescribed drugs ... -
In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:256, Doctoral thesis, 2007)Omsetningen av naturlegemidler og kosttilskudd har økt dramatisk de siste årene, og en økende aksept for urtebruk tilsier at forbruket fortsatt vil øke. Samtidig bruk av naturlegemidler/urter og legemidler forekommer ofte. ... -
In vitro validation of anticancer drug combinations on colon cancer cell lines SW620 and HCT116
(Master thesis, 2018)Combinatory drug treatment, e.g. targeting different proteins in specific signaling pathways tailored to an individual’s tumor, is expected to overcome problems related to individual variation in drug efficacy, resistance ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
(Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
In-Motion-App for remote General Movement Assessment: a multi-site observational study
(Peer reviewed; Journal article, 2021)Objectives: To determine whether videos taken by parents of their infants' spontaneous movements were in accordance with required standards in the In-Motion-App, and whether the videos could be remotely scored by a trained ... -
Incidence and Case Fatality of Aneurysmal Subarachnoid Hemorrhage Admitted to Hospital Between 2008 and 2014 in Norway
(Peer reviewed; Journal article, 2020)Background To provide age- and sex-specific incidence and case fatality rates for non-traumatic aneurysmal subarachnoid hemorrhage (aSAH) in Norway. We also studied time trends in incidence and case fatality, as well as ... -
Incidence and mortality of moderate and severe traumatic brain injury in children: A ten year population-based cohort study in Norway
(Peer reviewed; Journal article, 2019)Objective: In this study we wanted to estimate population-based rates of incidence and mortality of moderate and severe traumatic brain injury (TBI) in children in one specific region in Norway. Methods: In the region there ... -
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study. Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study
(Journal article; Peer reviewed, 2017)Background The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. ... -
Incidence and survival of multiple myeloma: a population-based study of 10 524 patients diagnosed 1982–2017
(Peer reviewed; Journal article, 2020)Population‐based studies from high‐quality nationwide cancer registries provide an important alternative to clinical trials in the assessment of the impact of modern myeloma treatment. Based on data from the Cancer Registry ... -
Incidence of invasive Group B Streptococcal infection and the risk of infant death and cerebral palsy: a Norwegian Cohort Study
(Peer reviewed; Journal article, 2020)Background Group B Streptococcus (GBS) is the leading cause of invasive neonatal infection worldwide. In high-income countries mortality rates are 4–10%, and among survivors of GBS meningitis 30–50% have neurodevelopmental ... -
Incidence, mortality and riskfactors of first venous thrombosisin a general population: Results from the second Nord-Trøndelag Health Study (HUNT 2)
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:12, Doctoral thesis, 2008)Venous thrombosis (VT) is the third most common cardiovascular disease after myocardial infarction and stroke. The most frequent clinical manifestation is thrombosis of the leg (deep venous thrombosis), which may embolize ... -
Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
(Peer reviewed; Journal article, 2022)Purpose Severe bacterial infections are important causes of hospitalization and loss of health worldwide. In this study we aim to characterize the total burden, recurrence and severity of bacterial infections in the ...