Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 1323-1342 of 3430

    • Geriatric assessment with management for older patients with cancer receiving radiotherapy. Protocol of a Norwegian cluster-randomised controlled pilot study 

      Røyset, Inga Marie; Saltvedt, Ingvild; Rostoft, Siri; Grønberg, Bjørn Henning; Kirkevold, Øyvind; Oldervoll, Line Merethe; Bye, Asta; Saltyte Benth, Jurate; Bergh, Sverre; Melby, Line; Halsteinli, Vidar; Døhl, Øystein; Røsstad, Tove Garåsen; Eriksen, Guro Falk; Sollid, May Ingvild Volungholen; Rolfson, Darryl; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2021)
      About 50% of patients with cancer are expected to need radiotherapy (RT), and the majority of these are older. To improve outcomes for older patients with cancer, geriatric assessment (GA) with management (GAM) is highly ...

    • Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Venizelos, Andreas; Sorbye, Halfdan; Elvebakken, Hege; Perren, Aurel; Lothe, Inger Marie Bowitz; Couvelard, Anne; Hjortland, Geir Olav; Sundlöv, Anna; Svensson, Johanna; Garresori, Herish; Kersten, Christian; Hofsli, Eva; Detlefsen, Sönke; Vestermark, Lene W.; Ladekarl, Morten; Tabaksblat, Elizaveta Mitkina; Knappskog, Stian (Peer reviewed; Journal article, 2023)
      High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NENs) are highly aggressive cancers. The molecular etiology of these tumors remains unclear, and the prevalence of pathogenic germline variants in patients ...

    • Germline variants at SOHLH2 influence multiple myeloma risk 

      Duran-Lozano, Laura; Thorleifsson, Gudmar; Lopez de Lapuente Portilla, Aitzkoa; Niroula, Abhishek; Went, Molly; Thodberg, Malte; Pertesi, Maroulio; Ajore, Ram; Cafaro, Caterina; Olason, P; Stefansdottir, Lilja; Bragi Walters, Walters; Halldorsson, Gisli H.; Turesson, Ingemar; Kaiser, Martin; Weinhold, Niels; Abildgaard, Niels; Andersen, Niels Frost; Mellqvist, Ulf-Henrik; Waage, Anders; Vangsted, Annette; Thorsteinsdottir, Unnur; Hansson, Markus; Houlston, Richard S.; Rafnar, Thorunn; Stefansson, Kari; Nilsson, Björn (Peer reviewed; Journal article, 2021)
      Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a ...

    • Gestational Age, Parent Education, and Education in Adulthood 

      Bilsteen, Josephine; Alenius, Suvi; Bråthen, Magne; Børch, Klaus; Ekstrøm, Claus Thorn; Kajantie, Eero Olavi; Lashkarian, Mariam; Nurhonen, Markku; Risnes, Kari Ravndal; Sandin, Sven; Wel, Kjetil A. van der; Wolke, Dieter; Nybo Andersen, Anne-Marie (Journal article; Peer reviewed, 2021)
      BACKGROUND: Adults born preterm (<37 weeks) have lower educational attainment than those born term. Whether this relationship is modified by family factors such as socioeconomic background is, however, less well known. We ...

    • Gestational Diabetes in Europe 

      Haugen, Elisabeth (Master thesis, 2009)

    • Gestational diabetes is associated with the risk of offspring's congenital anomalies: a register-based cohort study 

      Kinnunen, Jenni; Nikkinen, Hilkka; Keikkala, Elina; Mustaniemi, Sanna; Gissler, Mika; Laivuori, Hannele; Eriksson, Johan G.; Kaaja, Risto; Pouta, Anneli; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2023)
      Background Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of ...

    • Gestational weight gain outside the Institute of Medicine recommendations and adverse pregnancy outcomes: analysis using individual participant data from randomised trials 

      Rogozińska, Ewelina; Zamora, Javier; Marlin, Nadine; Betran, Ana Pilar; Astrup, Arne; Bogaerts, Annick; Cecatti, José Guilherme; Dodd, Jodie M.; Facchinetti, Fabio; Geiker, Nina Rica Wium; Haakstad, Lene Annette Hagen; Hauner, Hans; Jensen, Dorte M.; Kinnunen, Tarja I.; Mol, Ben Willem J.; Owens, Julie; Phelan, Suzanne; Renault, Kristina; Salvesen, Kjell Å; Shub, Alexis; Surita, Fernanda; Stafne, Signe Nilssen; Teede, Helena; van Poppel, Mireille N.M.; Vinter, Christina Anne; Khan, Khalid S.; Thangaratinam, Shakila (Journal article; Peer reviewed, 2019)
      Background:High Body Mass Index (BMI) and gestational weight gain (GWG) affect an increasing number ofpregnancies. The Institute of Medicine (IOM) has issued recommendations on the optimal GWG for womenaccording to their ...

    • Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: a longitudinal, placebo-controlled study 

      Molin, Johanna; Vanky, Eszter; Løvvik, Tone Shetelig; Dehlin, Eva; Bixo, Marie (Journal article; Peer reviewed, 2021)
      Objective To explore mechanisms that modulate gestational weight gain (GWG) in women with polycystic ovary syndrome (PCOS) and healthy controls. Design Sub-sample of randomised controlled trials (PCOS) combined with a ...

    • Glioblastom hos voksne 

      Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland; Bjørås, Magnar; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Sund, Fredrik; Bjerkvig, Rolf; Miletic, Hrvoje; Johannessen, Tor-Christian Aase; Sundstrøm, Terje (Peer reviewed; Journal article, 2023)
      lioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ...

    • Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence 

      Dragset, Marte Singsås; Ioerger, Thomas R.; Loevenich, Maja; Haug, Markus; Sivakumar, Niruja; Marstad, Anne; Cardona, Pere-Joan; Klinkenberg, Geir; Rubin, Eric J.; Steigedal, Magnus; Flo, Trude Helen (Journal article; Peer reviewed, 2019)
      Nontuberculous mycobacterial infections caused by the opportunistic pathogen Mycobacterium avium subsp. hominissuis (MAH) are currently receiving renewed attention due to increased incidence combined with difficult treatment. ...

    • Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy 

      Paunas, Theodora Ioana; Finne, Kenneth; Leh, Sabine Maria; Marti, Hans-Peter; Mollnes, Tom Eirik; Berven, Frode; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2017)
      Background The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with ...

    • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

      Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ...

    • Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death 

      Borges, Jazlyn P.; Sætra, Ragnhild Sofie Ragnhildstveit; Volchuk, Allen; Bugge, Marit; Devant, Pascal; Sporsheim, Bjørnar; Kilburn, Bridget R.; Evavold, Charles L.; Kagan, Jonathan C.; Goldenberg, Neil M.; Flo, Trude Helen; Steinberg, Benjamin Ethan (Peer reviewed; Journal article, 2022)
      First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple ...

    • gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation 

      Standal, Therese; Johnson, Rachelle; McGregor, Narelle; Poulton, Ingrid; Ho, Patricia W M; Martin, T. John; Sims, Natalie (Journal article; Peer reviewed, 2014)
      Parathyroid hormone (PTH) treatment stimulates osteoblast differentiation and bone formation, and is the only currently approved anabolic therapy for osteoporosis. In cells of the osteoblast lineage, PTH also stimulates ...

    • Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5‐deficient individual 

      Hardersen, Randolf Inge; Enebakk, Terje; Christiansen, Dorte; Bergseth, Grete; Brekke, Ole-Lars; Mollnes, Tom Eirik; Lappegård, Knut Tore; Hovland, Anders (Journal article, 2018)
      The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D) individual, comparing it to C5‐deficient blood reconstituted ...

    • GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients 

      Neckmann, Ulrike; Wolowczyk, Camilla; Hall, Martina; Almaas, Eivind; Ren, Jiang; Zhao, Sen; Johannessen, Bjarne; Skotheim, Rolf I.; Bjørkøy, Geir; Dijke, Peter Ten; Holien, Toril (Journal article; Peer reviewed, 2019)
      Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ...

    • Growth and survival of follicular and diffuse large B cell lymphoma cells: the role of toll-like receptors and their ligands, IL-21, BMP-4 and BMP-6 

      Kvam, Solveig (Master thesis, 2010)
      The main purpose of this thesis was to characterize the expression of toll-like receptors (TLRs) and to investigate the role of TLR-induced responses in growth and survival of follicular lymphoma (FL) and diffuse large ...

    • Growth during infancy and early childhood in children with cerebral palsy: a population-based study 

      Strand, Kristin Melheim; Dahlseng, Magnus Odin; Lydersen, Stian; Rø, Torstein Baade; Finbråten, Ane-Kristine; Jahnsen, Reidun; Andersen, Guro Lillemoen; Vik, Torstein (Peer reviewed; Journal article, 2016)
      Aim To describe growth in infancy and early childhood in children with cerebral palsy (CP). Method One hundred and four children with CP born at minimum 36 weeks' gestation in 2002 to 2010 were included. Prospectively ...

    • Growth, Nutritional Status, and Feeding Difficulties in Children with Cerebral Palsy 

      Dahlseng, Magnus Odin (Doctoral thesis at NTNU;2015:12, Doctoral thesis, 2015)
      Cerebral palsy (CP) is the most common cause of chronic motor disability in childhood, and is caused by an early injury affecting the parts of the brain responsible for body movement and control. In addition to motor ...

    • Guanylate cyclase-C signaling in Inflammatory Bowel Disease: Cellular expression of guanylin and uroguanylin encoding genes in human and rat duodenum and colon 

      Brenna, Øystein (Doctoral theses at NTNU;2016:131, Doctoral thesis, 2016)