Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1285-1304 of 3430
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Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models
(Peer reviewed; Journal article, 2020)Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double-strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J ... -
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
(Peer reviewed; Journal article, 2022)Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies ... -
Genetic predisposition for development of preeclampsia: Candidate gene studies in the HUNT(Nord-Trøndelag Health Study) population
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:157, Doctoral thesis, 2009)Preeclampsia is a major cause of maternal morbidity and mortality in the western world, and approximately 63,000 women dye yearly of the disease worldwide. This disorder is characterized by increased maternal blood pressure ... -
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
(Peer reviewed; Journal article, 2020)Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ... -
Genetic Predisposition to Preeclampsia: Genetic Association Studies on Population-Based Cohorts and Transcriptional Studies on Decidua Basalis Tissue
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:47, Doctoral thesis, 2014) -
Genetic Rescue of the Highly Inbred Norwegian Lundehund
(Journal article; Peer reviewed, 2022)Augmenting the genetic diversity of small, inbred populations by the introduction of new individuals is often termed “genetic rescue“. An example is the Norwegian Lundehund, a small spitz dog with inbreeding-related health ... -
Genetic Risk Factors for Lung Cancer: Relationship to Smoking Habits and Nicotine Addiction: The Nord-Trøndelag (HUNT) and Tromsø Health Studies
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:87, Doctoral thesis, 2013) -
Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
(Peer reviewed; Journal article, 2020)Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a ... -
Genetic studies of candidate genes in Parkinson’s disease
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:324, Doctoral thesis, 2008)The genetics of Parkinson’s disease (PD) have been extensively studied during recent years. This thesis presents an investigation of genetic causes of Parkinson’s disease in differently structured population samples using ... -
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
(Peer reviewed; Journal article, 2021)Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ... -
Genetic Susceptibility to Preeclampsia: Studies on the Nord-Trøndelag Health Study (HUNT) Cohort, an Australian/New Zealand Family Cohort and Decidua Basalis Tissue
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:63, Doctoral thesis, 2011)Genetisk disposisjon for utvikling av svangerskapsforgiftning : Studier fra Helseundersøkelsen i Nord-Trøndelag, en familiekohort fra Australia/New Zealand og decidua basalis vev Svangerskapsforgiftning er en alvorlig ... -
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
(Peer reviewed; Journal article, 2021)Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The ... -
Genetic variants related to physical activity or sedentary behaviour: a systematic review
(Peer reviewed; Journal article, 2021)Background Research shows that part of the variation in physical activity and sedentary behaviour may be explained by genetic factors. Identifying genetic variants associated with physical activity and sedentary behaviour ... -
Genetic variation and cognitive dysfunction in opioid-treated patients with cancer
(Peer reviewed; Journal article, 2016)Background and purpose The effects of single‐nucleotide polymorphisms (SNPs) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but they could potentially be related to ... -
Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium
(Journal article; Peer reviewed, 2019)Members of the Mycobacterium avium complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing ... -
Genmodifisert maislinje MON810. Uttalelse fra Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 09.11.07
(VKM Report;, Research report, 2007) -
Genome editing in food and feed production – implications for risk assessment
(Peer reviewed; Journal article, 2021)The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ... -
Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment
(Journal article; Peer reviewed, 2021)The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ... -
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
(Peer reviewed; Journal article, 2021)Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ... -
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
(Peer reviewed; Journal article, 2022)Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...