• NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture 

      Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra (Journal article; Peer reviewed, 2017)
      Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a ...
    • Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial 

      Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne; Mortensen, Kim Erlend; Smaaland, Rune; Sorbye, Halfdan; Verbeke, Caroline Sophie; Dueland, Svein (Journal article; Peer reviewed, 2017)
      Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ...
    • NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates. 

      Vik, Sigrid Dannheim; Torp, Hans; Follestad, Turid; Støen, Ragnhild; Nyrnes, Siri Ann (Journal article; Peer reviewed, 2019)
      BACKGROUND: There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. ...
    • Neonatal biomarkers and morbidity as risk factors for visual impairment in extremely low gestational age newborns 

      Holm, Mari (Doctoral theses at NTNU;2017:183, Doctoral thesis, 2017)
      Being born preterm imposes a risk of increased mortality and numerous morbidities on the infant. Preterm newborns carry their "birth history" with them throughout life; this implies an increased risk of problems related ...
    • Nephronectin in breast cancer progression and metastasis 

      Toraskar, Jimita Prashant (Doctoral theses at NTNU;2018:390, Doctoral thesis, 2018)
      Breast cancer is life threatening due to its ability to spread and invade other tissues. The best approach in solving a problem of this sort is to be able to reason backwards. Tumors appear chaotic as they are composed of ...
    • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

      Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2018)
      Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in ...
    • Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine 

      Comte, Blandine; Baumbach, Jan; Benis, Arriel; Basílio, José; Debeljak, Nataša; Flobak, Åsmund; Franken, Christian; Harel, Nissim; He, Feng; Kuiper, Martin; Juan Albino Méndez, Pérez; Pujos-Guillot, Estelle; Režen, Tadeja; Rozman, Damjana; Schmid, Johannes A; Scerri, Jeanesse; Tieri, Paolo; Van Steen, Kristel; Sona, Vasudevan; Watterson, Steven; Schmidt, Harald H H W (Journal article; Peer reviewed, 2020)
      Introduction: Network and systems medicine has rapidly evolved over the past decade, thanks to computational and integrative tools, which stem in part from systems biology. However, major challenges and hurdles are still ...
    • Neural correlates of working memory training in HIV patients: Study protocol for a randomized controlled trial 

      Chang, Linda; Løhaugen, Gro; Douet, Vanessa; Miller, Eric N.; Skranes, Jon Sverre; Ernst, Thomas (Peer reviewed; Journal article, 2016)
      Background Potent combined antiretroviral therapy decreased the incidence and severity of HIV-associated neurocognitive disorders (HAND); however, no specific effective pharmacotherapy exists for HAND. Patients with HIV ...
    • Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. 

      Dubeykovskaya, Z; Si, Y; Chen, X; Worthley, DL; Renz, BW; Urbanska, AM; Hayakawa, Y; Xu, T; Westphalen, CB; Dubeykovskiy, A; Chen, Duan; Friedman, RA; Asfaha, S; Nagar, S; Tailor, Y; Muthupalani, S; Fox, JG; Kitajewski, J; Wang, Timothy C. (Peer reviewed; Journal article, 2016)
      CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and ...
    • Neurodevelopmental origins of lifespan changes in brain and cognition 

      Walhovd, Kristine B; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Bartsch, Hauke; Bjørnerud, Atle; Due-Tønnessen, Paulina; Grydeland, Håkon; Hagler, D.; Håberg, Asta; Kremen, William S.; Ferschmann, Lia; Nyberg, Lars; Panizzon, Matthew S; Rohani, Darius; Skranes, Jon Sverre; Storsve, Andreas Berg; Sølsnes, Anne Elisabeth; Tamnes, Christian Krog; Thompson, Wesley K.; Reuter, Chase; Dale, Anders; Fjell, Anders Martin (Journal article; Peer reviewed, 2016)
      Neurodevelopmental origins of functional variation in older age are increasingly being acknowledged, but identification of how early factors impact human brain and cognition throughout life has remained challenging. Much ...
    • Neuroendocrine Aspects of Physiology and Disease 

      Hauso, Øyvind (Doktoravhandlinger ved NTNU, 1503-8181; 2009:93, Doctoral thesis, 2009)
      De nevroendokrine celler står i en mellomstilling mellom nerveceller (nevro-) og hormonproduserende celler (-endokrine). Disse finnes i et helt spekter, spredt i overflaten av kroppens fleste organer. To viktige nevroendokrine ...
    • Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy 

      Ystgaard, Martin Bogale; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar; Ranheim, Trine; Sagen, Ellen Lund; Halvorsen, Bente; Saugstad, Ola Didrik; Yndestad, Arne (Journal article; Peer reviewed, 2019)
      Background: Following birth asphyxia there is a robust inflammatory response. NLRP3 is a receptor of the innate immune system. Upon activation, NLRP3 forms an inflammasome together with ASC and procaspase-1 to mediate ...
    • Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain 

      Morken, Tora Sund; Brekke, Eva Mari Førland; Håberg, Asta; Widerøe, Marius; Brubakk, Ann-Mari; Sonnewald, Ursula (Journal article; Peer reviewed, 2014)
      Glucose and acetate metabolism and the synthesis of amino acid neurotransmitters, anaplerosis, glutamate-glutamine cycling and the pentose phosphate pathway (PPP) have been extensively investigated in the adult, but not ...
    • Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation 

      Mjønes, Patricia; Sagatun, Liv; Nordrum, Ivar Skjåk; Waldum, Helge (Journal article; Peer reviewed, 2017)
      The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being ...
    • Neuropsychological functioning and quantitative cerebral MRI in young adults born Small-for-Gestational-Age at term 

      Østgård, Heidi Furre (Doktoravhandlinger ved NTNU, 1503-8181; 2014:185, Doctoral thesis, 2014)
      Fetal growth restriction (FGR) is said to occur in 3-10% of fetuses. The term small-for-gestational-age (SGA) is used as a proxy for FGR in epidemiological studies, and is defined as a birth weight cut-off, adjusted for ...
    • Neutrophil activation in a roller pump model of cardiopulmonary bypass:  Influence of biomaterial, platelets and complement 

      Åsberg, Ann Elisabeth (Doktoravhandlinger ved NTNU, 1503-8181; 2008:104, Doctoral thesis, 2008)
        Background: In cardiac surgery with cardiopulmonary bypass a complex systemic inflammatory response can arise postoperatively, causing serious complications such as the development of multi-organ dysfunction. ...
    • Neutrophil gelatinase-associated lipocalin in inflammatory bowel disease 

      Thorsvik, Silje (Doctoral theses at NTNU;2019:108, Doctoral thesis, 2019)
      Nøytrofil gelatinase-assosiert lipocalin i inflammatorisk tarmsykdom Inflammatorisk tarmsykdom (IBD) er kroniske betennelsestilstander i mage-tarmsystemet. De to hovedformene er Crohns sykdom (CD) og ulcerøs kolitt (UC). ...
    • New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss. 

      Johns, Neil; Stretch, C; Tan, BH; Solheim, Tora Skeidsvoll; Sørhaug, Sveinung; Stephens, NA; Gioulbasanis, Ioannis; Skipworth, RJ; Deans, DA; Vigano, Antonio A.L.; Ross, JA; Bathe, OF; Tremblay, ML; Kaasa, Stein; Strasser, Florian; Gagnon, B; Baracos, VE; Damaraju, S; Fearon, KC (Peer reviewed; Journal article, 2017)
      Background Cachexia affects the majority with advanced cancer. Based on current demographic and clinical factors, it is not possible to predict who will develop cachexia or not. Such variation may, in part, be due to ...
    • New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma 

      Kovcic, Vlado (Doctoral theses at NTNU;2020:124, Doctoral thesis, 2020)
      Multiple myeloma is a haematological malignancy characterized by uncontrolled proliferation of malignant plasma cells. The myeloma cells secrete immunoglobulins, which leads to the presence of high levels of monoclonal ...
    • New relative intensity ambulatory accelerometer thresholds for elderly men and women: The Generation 100 study 

      Zisko, Nina; Carlsen, Trude; Salvesen, Øyvind; Aspvik, Nils Petter; Ingebrigtsen, Jan Erik; Wisløff, Ulrik; Stensvold, Dorthe (Journal article; Peer reviewed, 2015)
      Background Public health initiatives world-wide recommend increasing physical activity (PA) to improve health. However, the dose and the intensity of PA producing the most benefit are still debated. Accurate assessment ...