Blar i Institutt for klinisk og molekylær medisin på tittel
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Re-assessment of the plant protection product PROMAN – with the active ingredient metobromuron. Opinion of the Panel on Plant Protection Products of the Norwegian Scientific Committee for Food Safety
(VKM Report;, Research report, 2015)Proman is a broad spectrum selective herbicide for potatoes grown outdoors, containing the active substance metobromuron. VKM’s Panel on Plant Protection Products has previously discussed questions concerning Proman raised ... -
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro
(Journal article; Peer reviewed, 2014)Abstract. Photodynamic therapy (PDT) and photodiagnosis based on the intracellular production of the photosensitizer protoporphyrin IX (PPIX) by administration of its metabolic precursor δ-aminolevulinic acid (ALA) achieved ... -
Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study
(Peer reviewed; Journal article, 2022)Background Etanercept (ETN) and adalimumab (ADA) are considered equally effective biologicals in the treatment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported ... -
Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer
(Peer reviewed; Journal article, 2023)Objectives The aim of this study was to provide real-world efficacy and safety data on niraparib maintenance treatment in patients with non-germline (gBRCA)1/2 mutated platinum-sensitive recurrent ovarian cancer. Methods ... -
Reasons for prolonged time for diagnostic workup for stage I-II lung cancer and estimated effect of applying an optimized pathway for diagnostic procedures
(Journal article; Peer reviewed, 2019)Background:Minimizing the time until start of cancer treatment is a political goal. In Norway, the target time forlung cancer is 42 days. The aim of this study was to identify reasons for delays and estimate the effect on ... -
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids
(Peer reviewed; Journal article, 2022)Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. ... -
Receptor binding competition: A paradigm for regulating TGF-β family action
(Peer reviewed; Journal article, 2020)The transforming growth factor (TGF)-β family is a group of structurally related, multifunctional growth factors, or ligands that are crucially involved in the development, regulation, and maintenance of animal tissues. ... -
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification
(Journal article; Peer reviewed, 2019)The wobble hypothesis was proposed to explain the presence of fewer tRNAs than possible codons. The wobble nucleoside position in the anticodon stem-loop undergoes a number of modifications that help maintain the efficiency ... -
Recommendations for the FAIRification of genomic track metadata
(Journal article; Peer reviewed, 2021) -
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
(Journal article; Peer reviewed, 2015)Chronic inflammation of the arterial wall is a key element in the development of atherosclerosis, and cholesterol crystals (CC) that accumulate in plaques are associated with initiation and progression of the disease. We ... -
Record linkage as a vital key player for the COVID-19 syndemic – The call for legal harmonization to overcome research challenges
(Peer reviewed; Journal article, 2023)The initial public health response to the COVID-19 pandemic aimed to prevent exponential dissemination and circumvent drastic collapses of healthcare systems [1]. Containment measures and required isolation promoted sedentary ... -
Recovery trajectories in common musculoskeletal complaints by diagnosis contra prognostic phenotypes
(Peer reviewed; Journal article, 2021)Background There are large variations in symptoms and prognostic factors among patients sharing the same musculoskeletal (MSK) diagnosis, making traditional diagnostic labelling not very helpful in informing treatment ... -
Rectal cancer surgery: Prognostic Factors Related to Treatment
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:284, Doctoral thesis, 2012)Background Towards the end of the 80-ties, 28 % of the rectal cancer patients treated for cure developed local recurrence, and only 55 % survived five years. Since 1993, intensified focus on the rectal cancer patients has ... -
Rectal cancer treatment: Considerations on early stages, risk prediction and influence of age
(Doctoral thesis at NTNU;2016:86, Doctoral thesis, 2016)Målsetningen med studiene i denne avhandlingen var å bidra til å bedre prognose ved behandling av rektumcancer, med spesielt fokus på pasienter over 75 år. Prognosen ved kolorektal cancer (CRC) i Norge har de siste 20-30 ... -
Recurrent malignant ventricular arrhythmias and paresthesia—a mystery revealed as aconitine poisoning: a case report
(Peer reviewed; Journal article, 2023)Background: We report a case of a clinical challenge lasting for 12 months, with severe and unresolved clinical features involving several medical disciplines. Case presentation: A 53-year-old Caucasian male, who had been ... -
Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro
(Journal article; Peer reviewed, 2014)Abstract. Hexyl 5-aminolevulinate (HAL) is a lipophilic derivative of 5-aminolevulinate, a key intermediate in biosynthesis of the photosensitizer protoporphyrin IX (PpIX). The photodynamic efficacy and cell death mode ... -
Reduced cardiorespiratory fitness is a mediator of excess all-cause mortality in rheumatoid arthritis: The Trøndelag Health Study
(Peer reviewed; Journal article, 2021)Objectives Investigate if low cardiorespiratory fitness (CRF) was associated with and acted as a mediator of excess all-cause mortality rate in persons suffering from rheumatoid arthritis (RA) compared with the general ... -
Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW)
(Journal article; Peer reviewed, 2019)Background The hippocampus, an essential structure for learning and memory, has a reduced volume in preterm born (gestational age < 37 weeks) individuals with very low birth weight (VLBW: birth weight < 1500 g), which ... -
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
(Journal article, 2017)Objectives. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to ... -
Reduced LDL-Cholesterol and Reduced Total Cholesterol as Potential Indicators of Early Cancer in Male Treatment-Naïve Cancer Patients With Pre-cachexia and Cachexia
(Peer reviewed; Journal article, 2020)Cancer cachexia is characterized by the impairment of glucose and lipid homeostasis, the acceleration of processes promoting the mobilization of energy-rich compounds (e.g., insulin resistance, gluconeogenesis, and lipolysis) ...