Blar i Institutt for klinisk og molekylær medisin på tittel
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A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer
(Journal article; Peer reviewed, 2016)Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor ... -
A ChIP-Seq Benchmark Shows That Sequence Conservation Mainly Improves Detection of Strong Transcription Factor Binding Sites
(Journal article; Peer reviewed, 2011)Background: Transcription factors are important controllers of gene expression and mapping transcription factor binding sites (TFBS) is key to inferring transcription factor regulatory networks. Several methods for ... -
A comparison of CT based measures of skeletal muscle mass and density from the Th4 and L3 levels in patients with advanced non-small-cell lung cancer
(Journal article; Peer reviewed, 2018)Background: Muscle mass and density assessed from CT-images at the L3 level are prognostic for survival and predict toxicity in cancer patients. However, L3 is not always included on routine CT-scans. We aimed to investigate ... -
A comprehensive analysis of the structure-function relationship in proteins based on local structure similarity
(Peer reviewed; Journal article, 2009)Background:Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that ... -
A Computational Analysis of Motif-Negative VDR-DNA Interaction and Possible Explanations of Its Mechanism of Interaction
(Master thesis, 2014)Transcription factor binding to DNA has generally been assumed to be as a result of the recognition of sequence-specific motifs in the transcription factor binding sites. Recent studies have however shown several examples ... -
A conservative weight loss intervention relieves bowel symptoms in morbidly obese subjects with irritable bowel syndrome: a prospective cohort study
(Journal article; Peer reviewed, 2018)Background. Irritable bowel syndrome (IBS) is common in subjects with morbid obesity; the effect of weight loss programs on bowel symptoms is largely unknown. Methods. This prospective cohort study explored bowel symptoms, ... -
A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer
(Journal article; Peer reviewed, 2017)Purpose The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the ... -
A data driven approach reveals disease similarity on a molecular level
(Journal article; Peer reviewed, 2019)Could there be unexpected similarities between different studies, diseases, or treatments, on a molecular level due to common biological mechanisms involved? To answer this question, we develop a method for computing ... -
A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat
(Journal article; Peer reviewed, 2013)Several findings have indicated an involvement of dopamine in panic and defensive behaviors. The dorsolateral column of the periaqueductal gray (dlPAG) is crucially involved in the expression of panic attacks in humans and ... -
A Dual Role of Autophagy in Disease Prevention and Drug Resistance
(Doctoral thesis at NTNU;2015:310, Doctoral thesis, 2015)Aging is associated with various diseases, such as neurodegenerative diseases. However, individual risk of developing these age-related diseases clearly varies due to differences in both genetic and environmental factors. ... -
A European multi-centre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
(Journal article; Peer reviewed, 2019)Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ... -
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
(Journal article; Peer reviewed, 2019)Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ... -
A Functional Polymorphism C-509T in TGFβ-1 Promoter Contributes to Susceptibility and Prognosis of Lone Atrial Fibrillation in Chinese Population
(Journal article; Peer reviewed, 2014)Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509T polymorphism (rs1800469) was genotyped ... -
A high precision method for quantitative measurements of reactive oxygen species in frozen biopsies
(Journal article; Peer reviewed, 2014)Objective: An electron paramagnetic resonance (EPR) technique using the spin probe cyclic hydroxylamine 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) was introduced as a versatile method for high ... -
A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
(Journal article; Peer reviewed, 2019)While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual ... -
A longitudinal study of associations between psychiatric symptoms and disorders and cerebral gray matter volumes in adolescents born very preterm
(Journal article; Peer reviewed, 2017)Background:Being born preterm with very low birthweight (VLBW≤1500 g) poses a risk for cortical andsubcortical gray matter (GM) abnormalities, as well as for having more psychiatric problems during childhood andadolescence ... -
A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs
(Journal article; Peer reviewed, 2011)Chromatin immunoprecipitation (ChIP) followed by high throughput sequencing (ChIP-seq) is rapidly becoming the method of choice for discovering cell-specific transcription factor binding locations genome wide. By aligning ... -
A massive parallel sequencing workflow for diagnostic genetic testing of mismatch repair genes
(Journal article; Peer reviewed, 2014)The purpose of this study was to develop a massive parallel sequencing (MPS) workflow for diagnostic analysis of mismatch repair (MMR) genes using the GS Junior system (Roche). A pathogenic variant in one of four MMR genes, ... -
A method to assess obstetric outcomes using the 10-Group Classification System: A quantitative descriptive study
(Journal article; Peer reviewed, 2017)Objectives Internationally, the 10-Group Classification System (TGCS) has been used to report caesarean section rates, but analysis of other outcomes is also recommended. We now aim to present the TGCS as a method to assess ... -
A new approach to the study of middle cerebral artery occlusion in the rat using magnetic resonance techniques
(Dissertations at the Faculty of Medicine, 0805-7680; 200, Doctoral thesis, 2001)