Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 91-110 av 3587
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Adjuvant platinum-based chemotherapy in non-small cell lung cancer: The role of relative dose-intensity and treatment delay
(Peer reviewed; Journal article, 2021)Background The study investigated the association of the relative dose-intensity (RDI) of cisplatin and timing of adjuvant platinum-based chemotherapy (APC) with survival for stage I-III non-small cell lung cancer (NSCLC) ... -
Admissions and surgery as indicators of hospital functions in Sierra Leone during the west-African Ebola outbreak
(Journal article; Peer reviewed, 2018)Background In an attempt to assess the effects of the Ebola viral disease (EVD) on hospital functions in Sierra Leone, the aim of this study was to evaluate changes in provisions of surgery and non-Ebola admissions during ... -
Adult outcomes of being born late preterm or early term – What do we know?
(Journal article; Peer reviewed, 2018)The literature on adult outcomes of people born late preterm (LPT, 34–36 completed weeks) or early term (ET, 37–38 weeks) was reviewed. In PubMed, 9547 articles were identified; 53 were eligible. Of these, 12 were based ... -
Adverse childhood experiences and prepregnancy body mass index in the HUNT study: A population-based cohort study
(Peer reviewed; Journal article, 2023)Objective Investigate the association between adverse childhood experiences and pre-pregnancy body mass index (BMI) in a population-based cohort in Trøndelag county, Norway. Materials and methods We linked data from ... -
Adverse effects of proton pump inhibitors – evidence and plausibility
(Journal article; Peer reviewed, 2019)Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential ... -
Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis
(Journal article; Peer reviewed, 2019)Objective Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of ... -
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
(Journal article; Peer reviewed, 2018)Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to ... -
Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study
(Peer reviewed; Journal article, 2023)Background: The roles of age at menarche and age at menopause in the etiology of lung and colorectal cancers are unclear. Objective: We aimed to investigate potential causal associations between age at menarche, age at ... -
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
(Peer reviewed; Journal article, 2022)Oxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating ... -
Age-specific prevalence of the metabolic syndrome defined by the international diabetes federation and the National Cholesterol Education Program: The Norwegian HUNT 2 study
(Journal article; Peer reviewed, 2007)Background The 2005 International Diabetes Federation (IDF) definition of the metabolic syndrome was designed to be useful worldwide, but to date few prevalence studies have used that definition in European populations. ... -
Agreement between transperineal ultrasound measurements and digital examinations of cervical dilatation during labor
(Journal article; Peer reviewed, 2015)Background To compare 2D transperineal ultrasound assessment of cervical dilatation with vaginal examination and to investigate intra-observer variability of the ultrasound method. Methods A prospective observational ... -
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature
(Journal article; Peer reviewed, 2014)tThe most common mutations in cancer are C to T transitions, but their origin has remained elusive.Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many com-mon cancers, suggesting ... -
Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
(Journal article; Peer reviewed, 2021)Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on ... -
ALASCA: An R package for longitudinal and cross-sectional analysis of multivariate data by ASCA-based methods
(Journal article; Peer reviewed, 2022) -
Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts
(Peer reviewed; Journal article, 2021)Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ... -
Alginate capsules as bioreactors for cell therapy
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:24, Doctoral thesis, 2006) -
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
(Journal article; Peer reviewed, 2017)Alginate microspheres are presently under evaluation for future cell-based therapy. Their ability to induce harmful host reactions needs to be identified for developing the most suitable devices and efficient prevention ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
(Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Peer reviewed, 2016)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere ...