Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 111-130 of 3431
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The allosteric modulation of complement c5 by knob domain peptides
(Peer reviewed; Journal article, 2021)Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 ... -
Alpha-cyclodextrin inhibits cholesterol crystal-induced complement-mediated inflammation: A potential new compound for treatment of atherosclerosis.
(Peer reviewed; Journal article, 2019)Background and aims Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis ... -
Alpha-tocopherol and MRI outcomes in multiple sclerosis - association and prediction
(Journal article; Peer reviewed, 2013)Objective: Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship ... -
Alterations in inflammatory biomarkers and energy intake in cancer cachexia: a prospective study in patients with inoperable pancreatic cancer
(Journal article; Peer reviewed, 2016)Chronic systemic inflammatory response is proposed as an underlying mechanism for development of cancer cachexia. We conducted a prospective study to examine changes in inflammatory biomarkers during the disease course and ... -
Alterations in the Vitamin D endocrine system during pregnancy: A longitudinal study of 855 healthy Norwegian women
(Journal article; Peer reviewed, 2018)To ensure optimal calcium accrual in the fetal skeleton, a substantial rise occurs in 1,25-dihydroxyvitamin D (1,25(OH)2D), but is dependent on sufficient 25-hydroxyvitamin (25(OH)D). Large longitudinal studies addressing ... -
Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults
(Peer reviewed; Journal article, 2020)Viral-transduced gene expression is the current standard for cell-type-specific labeling and cell tacking in experimental neuroscience. To achieve widespread gene expression, a viral delivery method to neonatal rodents was ... -
An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome
(Peer reviewed; Journal article, 2019)Purpose Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members with a ... -
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure
(Journal article; Peer reviewed, 2021)Objective Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase ... -
Amongst Norwegian paediatricians there is little agreement in management of cases of suspected child maltreatment
(Peer reviewed; Journal article, 2021)Aim Child maltreatment is not unusual in our society but little is known about the medical management of cases in the Nordic countries. This study investigated physician knowledge and practice in cases of suspected physical ... -
Amsterdam Complex Pelvic Pain Symptom Scale with subscales: Based on a Norwegian translation, psychometric assessment and modification of the Amsterdam Hyperactive Pelvic Floor scale
(Peer reviewed; Journal article, 2023)Introduction Women with an abnormally high pelvic floor muscle tone may have a clinical presentation that is complex, involving urinary, anorectal and/or sexual dysfunction, genital/pelvic pain and psychological distress. ... -
An Agile Approach to Novel Recombinant Antithrombin Production for use in Biologics Development
(Master thesis, 2019)Background: Sepsis is a deadly medical condition caused by a runaway inflammatory response to systemic infection in which the release of extracellular cytotoxic histones has been linked to disease progression. Heparin ... -
An Attempt to Elucidate the Genes Encoding the Surface Exposed Proteins R3, Z1 and Z2 in Two Strains of Streptococcus agalactiae from Zimbabwe
(Master thesis, 2014)Surface exposed proteins of Streptococcus agalactiae (GBS) may be used in serotyping and may have a potential role as vaccine candidates. The proteins R3 and the recently discovered Z1 and Z2 were found to be important ... -
An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay
(Journal article; Peer reviewed, 2019)Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ... -
An international measure of awareness and beliefs about cancer: development and testing of the ABC
(Journal article; Peer reviewed, 2012)Objectives: To develop an internationally validated measure of cancer awareness and beliefs; the awareness and beliefs about cancer (ABC) measure. Design and setting: Items modified from existing measures were assessed ... -
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells
(Journal article; Peer reviewed, 2013)Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 ... -
An investigation of potential variables affecting the physiological adaptations to weight loss: weight loss rate, nature of energy restriction, and ketosis
(Doctoral theses at NTNU;2018:53, Doctoral thesis, 2018)Various reviews published over the last decades have shown that several compensatory responses on both sides of the energy balance (EB) equation are activated with weight loss (WL), which oppose the maintenance of a reduced ... -
Analgesic use in a Norwegian general population: Change over time and high-risk use - The Tromsø Study
(Journal article; Peer reviewed, 2015)Background Increased use of analgesics in the population is a cause for concern in terms of drug safety. There is a paucity of population-based studies monitoring the change in use over time of both non-prescription ... -
Analyse av eksogene og endogene opioide peptider i dry blood spots ved bruk av HPLC-MS
(Master thesis, 2019)Opioide peptider forekommer både som eksogene- og som endogene peptider. Endogene peptider er kroppens egne peptider som blant annet funger som eget kontrollsystem på smerter, mens eksogene peptider hovedsakelig kommer ... -
Analysis of CD4+ Th1 cells in immunity to intracellular Mycobacterium avium infection
(Master thesis, 2013)Mycobacterial infections are considered a major health problem internationally. Mycobacterium tuberculosis (Mtb), the infectious agent causing tuberculosis, kills 1.4 million people each year. Other non-tuberculous species ... -
Analysis of host immune parameters during M. avium infection
(Master thesis, 2012)The goal of this study was to establish and optimize methods to analyze effector cytokine levels and other parameters in murine tissue and plasma samples. These methods should then be used to study the role of regulatory ...