Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 3311-3330 of 3443
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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
(Journal article; Peer reviewed, 2019)The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is ... -
Unravel the Local Complexity of Biological Environments by MALDI Mass Spectrometry Imaging
(Peer reviewed; Journal article, 2021)Classic metabolomic methods have proven to be very useful to study functional biology and variation in the chemical composition of different tissues. However, they do not provide any information in terms of spatial ... -
Unraveling the role of LSD1 in murine intestinal epithelial development
(Bachelor thesis, 2019)Background: The intestinal epithelium is a vital organ that absorbs nutrients and water from luminal contents and provide protection against pathogens and chemicals through the stimulation of the immune system and secretion ... -
Unrecognized viral infections and chromosome abnormalities as a cause of fetal death – examination with fluorescence in situ hybridization, immunohistochemistry and polymerase chain reaction
(Journal article; Peer reviewed, 2017)Fifteen to 50% of fetal deaths remain unexplained after post-mortem examination depending on inclusion criteria and classification systems. Our aim was to examine a selection of unexplained fetal deaths in order to investigate ... -
Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals
(Journal article; Peer reviewed, 2017)Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ... -
Update on genetic predisposition to colorectal cancer and polyposis
(Journal article; Peer reviewed, 2019)The present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary ... -
Updating risk management recommendations to limit exposure of non-target Lepidoptera of conservation concern in protected habitats to Bt-maize pollen
(Journal article; Peer reviewed, 2015)Using mathematical modelling, the EFSA GMO Panel has previously quantified the risk to non-target (NT) Lepidoptera of conservation concern, potentially occurring within protected habitats, associated with the ingestion of ... -
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG
(Journal article; Peer reviewed, 2017)Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ... -
Uracil DNA Glycosylase UNG2 carrying the germline mutation Arg88Cys: Potential implications for adaptive immunity and cancer
(Master thesis, 2011)Uracil is normally found in RNA where it replaces the DNA base thymine. However, it can occur in DNA if misincorporated in place of thymine, or as a result of deamination of cytosine. Uracil is also a normal intermediate ... -
Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A
(Journal article; Peer reviewed, 2011)Uracil is removed from DNA by the conserved enzyme Uracil DNA N-glycosylase (UNG). Previously, we observed that inhibiting UNG in Xenopus egg extracts blocked assembly of CENP-A, a histone H3 variant. CENP-A is an essential ... -
Uracil in DNA - necessary intermediate for antibody maturation and mutagenic lesion
(Doctoral thesis at NTNU;2015:153, Doctoral thesis, 2015)Uracil in DNA - et viktig mellomprodukt for adaptiv immunitet og mutagen skade Uracil er en av fire nukleobaser i RNA, men små mengder kan også befinne seg i DNA. Det er to kilder til genomisk uracil: misinkorporering ... -
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
(Journal article; Peer reviewed, 2019)UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in ... -
Uracil-DNA glycosylase, activation-induced deaminase and regulation of adaptive immune responses
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:318, Doctoral thesis, 2012)Uracil-DNA glykosylase, activation-induced deaminase og regulering av ervervet immunitet Det eksterne miljøet er rikt på potensielle farer for alle multicellulære organismer. Det mammalske immunforsvaret er en barriere ... -
Ureteric injuries during hysterectomy—A Norwegian retrospective study of occurrence and claims for compensation over an 11-year period
(Peer reviewed; Journal article, 2021)Introduction: Ureteric injury is a rare but serious, iatrogenic complication of hysterectomy. The risk depends on indication for surgery, predisposing risk factors, and peroperative conditions. Our aims were to evaluate ... -
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
(Journal article; Peer reviewed, 2013)Objective: To investigate urine albumin leakage as a marker of endothelial dysfunction in migraine patients. Design: A population-based health study. Participants: 303 patients with migraine, 1009 patients with ... -
Urinary and colorectal-anal distress in women - prevalence, risk factors and effect of pelvic floor muscle exercise in women with pelvic organ prolapse
(Doctoral theses at NTNU;2021:199, Doctoral thesis, 2021) -
Urinary incontinence and drug use: Data from the Norwegian Prescription Database and the HUNT3 study
(Doctoral theses at NTNU;2018:125, Doctoral thesis, 2018)Introduction Urinary incontinence is a common health problem in the female population. The most common drug group used for the treatment of urgency urinary incontinence is anticholinergic drugs, including oxybutynin, ... -
Urinary Incontinence and Urinary Tract Infections in the Elderly: Risk Factors and Consequences
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:342, Doctoral thesis, 2012) -
Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria
(Journal article; Peer reviewed, 2015)Background: The contrast between a high prevalence of chronic kidney disease (CKD) and the low incidence of end-stage renal disease highlights the need for new biomarkers of progression beyond albuminuria testing. ... -
Urinveisinfeksjoner ved St. Olavs hospital HF
(Master thesis, 2020)Urinveisinfeksjoner (UVI) er blant de vanligste bakterielle infeksjonene og er årsak til en betydelig andel av antibiotikaforbruket i Norge. Over halvparten av alle kvinner vil gjennomgå én eller flere tilfeller av UVI i ...