Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 3291-3310 av 3512

    • Toll-like receptors and inflammation in pregnancy 

      Tangerås, Line Haugstad (Doctoral thesis at NTNU;2015:263, Doctoral thesis, 2015)
      Toll-lignende reseptorer og inflammasjon i svangerskapet Et normalt svangerskap kjennetegnes av en mild betennelsestilstand (inflammasjon) som involverer både morkaken og mors blodomløp. Dette er en del av kvinnekroppens ...

    • Toll-like receptors in placental tissue from women with and without complication of preeclampsia in pregnancy 

      Silva, Gabriela Brettas (Master thesis, 2014)
      Human pregnancy is characterized by a mild systemic inflammatory response that is essential for maternal metabolic adaptation and immunological tolerance to the semiallogeneic fetus. Trophoblasts are the placental cells ...

    • Toll-like receptors in placental tissue from women with and without complication of preeclampsia in pregnancy 

      Silva, Gabriela Brettas (Master thesis, 2014)
      Human pregnancy is characterized by a mild systemic inflammatory response that is essential for maternal metabolic adaptation and immunological tolerance to the semiallogeneic fetus. Trophoblasts are the placental cells ...

    • A Tool to Ensure Appropriate Drug Use and Maintain Patient Safety When Administering Pro Re Nata Medications: Healthcare Providers’ Experiences With Medicine Lists in Sheltered Housing for Older People 

      Nilsen, Marianne Kollerøs; Bell, Hege Therese (Chapter, 2022)
      Residents living in sheltered housing may need assistance with the administration of medications, including medications used as needed. Healthcare providers can then administer medications based on the resident’s medication ...

    • Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants 

      Eap, C.B.; Gründer, Gerhard; Baumann, P.; Ansermot, N.; Conca, A.; Corruble, E.; Crettol, S.; Dahl, Marja-Liisa; de Leon, Leon; Greiner, C.; Howes, Oliver D.; Kim, E.; Lanzenberger, R.; Meyer, J.H.; Moessner, R.; Mulder, H.; Müller, Daniel J.; Reis, Margareta; Riederer, P.; Ruhe, H.G.; Spigset, Olav; Spina, E.; Stegman, B.; Steimer, W.; Stingl, J.; Suzen, S.; Uchida, H.; Unterecker, S.; Vandenberghe, F.; Hiemke, C. (Peer reviewed; Journal article, 2021)
      Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient. ...

    • Top Ten Tips Palliative Care Clinicians Should Know About Cachexia 

      Blum, David; Vagnildhaug, Ola Magne; Stene, Guro Birgitte; Maddocks, Matthew; Sørensen, Jonas; Laird, Barry J; Prado, Carla M.; Solheim, Tora S; Arends, Jann; Hopkinson, Jane; Jones, Christopher A.; Schlögl, Mathias (Peer reviewed; Journal article, 2023)
      Cachexia is a multifactorial syndrome that is common in cancer and chronic disease. It is often underdiagnosed and therefore goes untreated or undertreated. Cachexia causes suffering across biopsychosocial domains and ...

    • TOP2A gene copy number change in breast cancer 

      Engstrøm, Monica J; Ytterhus, Borgny; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Peer reviewed; Journal article, 2014)
      Aims The clinical significance of TOP2A as a prognostic marker has not been clarified. The aims of this study were to investigate the frequency of TOP2A copy number change; to correlate TOP2A with HER2 status, hormone ...

    • Topical moistening of mastectomy wounds with diluted tranexamic acid to reduce bleeding: randomized clinical trial 

      Ausen, Kjersti; Hagen, Anne Irene; Sæther Østbyhaug, Heidi; Olafsson, Sverrir; Kvalsund, Berit; Spigset, Olav; Pleym, Hilde (Journal article; Peer reviewed, 2019)
      Background: Topical administration of tranexamic acid (TXA) may be an alternative to intravenous administration to reduce bleeding with a lower risk of systemic adverse events. The aim of this study was to investigate ...

    • TopoICSim: A new semantic similarity measure based on gene ontology 

      Ehsani, Rezvan; Drabløs, Finn Sverre (Peer reviewed; Journal article, 2016)
      Background The Gene Ontology (GO) is a dynamic, controlled vocabulary that describes the cellular function of genes and proteins according to tree major categories: biological process, molecular function and cellular ...

    • Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli 

      Helgesen, Emily; Sætre, Frank Ove; Skarstad, Kirsten Jane (Peer reviewed; Journal article, 2021)
      Topoisomerase IV (TopoIV) is a vital bacterial enzyme which disentangles newly replicated DNA and enables segregation of daughter chromosomes. In bacteria, DNA replication and segregation are concurrent processes. This ...

    • Total late effect burden in long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplant and its effect on health-related quality of life 

      Smeland, Knut Bjøro; Holte, Harald; Fagerli, Unn-Merete; Bersvendsen, Hanne Skjerven; Hjermstad, Marianne Jensen; Loge, Jon Håvard; Murbræch, Klaus; Linnsund, Marianne Dahl; Fluge, Øystein; Stenehjem, Jo Steinson; Samersaw-Lund, May Brit; Kvaløy, Stein Olav; Kiserud, Cecilie E. (Peer reviewed; Journal article, 2022)
      Lymphoma survivors after high-dose therapy with autologous stem-cell transplant (HDT-ASCT) are at risk of several late effects, which might impair their health-related quality of life (HRQoL). We assessed the total late ...

    • Towards human-level performance on automatic pose estimation of infant spontaneous movements 

      Groos, Daniel; Adde, Lars; Støen, Ragnhild; Ramampiaro, Heri; Ihlen, Espen Alexander F. (Peer reviewed; Journal article, 2021)
      Assessment of spontaneous movements can predict the long-term developmental disorders in high-risk infants. In order to develop algorithms for automated prediction of later disorders, highly precise localization of segments ...

    • Towards Making a Cyborg: A Closed-Loop Reservoir-Neuro System 

      Aaser, Peter; Knudsen, Martinius; Huse Ramstad, Ola; van de Wijdeven, Rosanne; Nichele, Stefano; Sandvig, Ioanna; Tufte, Gunnar; Bauer, Ulrich Stefan; Halaas, Øyvind; Hendseth, Sverre; Sandvig, Axel; Valderhaug, Vibeke Devold (Chapter; Peer reviewed, 2017)
      The human brain is a remarkable computing machine, i.e. vastly parallel, self-organizing, robust, and energy efficient. To gain a better understanding into how the brain works, a cyborg (cybernetic organism, a combination ...

    • Towards understanding of gastric cancer based upon physiological role of gastrin and ECL cells 

      Waldum, Helge; Mjønes, Patricia (Peer reviewed; Journal article, 2020)
      The stomach is an ideal organ to study because the gastric juice kills most of the swallowed microbes and, thus, creates rather similar milieu among individuals. Combined with a rather easy access to gastric juice, gastric ...

    • Toxicity of cytostatic drug-loaded nanoparticles: The role of endocytosis 

      Vogt, Trym Oliver (Master thesis, 2016)
      Poly alkyl cyanoacrylate nanoparticles have caught interest because of its desireable properties, such as biocompatibility and biodegradability. They are relatively easy to make and can entrap molecules which make them ...

    • Trace Elements in the Large Population-Based HUNT3 Survey 

      Syversen, Tore; Evje, Lars Gjermund; Wolf-Grosse, Susann; Flaten, Trond Peder; Lierhagen, Syverin; Simic, Anica (Peer reviewed; Journal article, 2020)
      The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey ...

    • Trajectories of brain development in school-age children born preterm with very low birth weight 

      Sripada, Kam; Bjuland, Knut Jørgen; Sølsnes, Anne Elisabeth; Håberg, Asta; Grunewaldt, Kristine Hermansen; Løhaugen, Gro; Rimol, Lars Morten; Skranes, Jon Sverre (Journal article; Peer reviewed, 2018)
      Preterm birth (gestational age < 37 weeks) with very low birth weight (VLBW, birth weight ≤ 1500 g) is associated with lifelong cognitive deficits, including in executive function, and persistent alterations in cortical ...

    • Trajectory of health-related quality of life during the last year of life in patients with advanced non-small–cell lung cancer 

      Kristensen, Are Korsnes; Grønberg, Bjørn Henning; Fløtten, Øystein; Kaasa, Stein; Solheim, Tora S (Peer reviewed; Journal article, 2022)
      Background The aims of this study were to assess the trajectory of health-related quality of life (HRQOL) during the last year of life in patients with advanced non-small–cell lung cancer (NSCLC) and to explore when and ...

    • Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease 

      Zheng, Jie; Zhang, Yuemiao; Rasheed, Humaira; Walker, Venexia M.; Sugawara, Yuka; Li, Jiachen; Leng, Yue; Elsworth, Benjamin; Wootton, Robyn E.; Fang, Si; Yang, Qian; Burgess, Stephen; Haycock, Philip C.; Borges, Maria Carolina; Carnegie, Rebecca; Cho, Yoonsu; Howell, Amy; Robinson, Jamie; Thomas, Laurent; Brumpton, Ben Michael; Hveem, Kristian; Hallan, Stein; Franceschini, Nora; Morris, Andrew P.; Köttgen, Anna; Pattaro, Cristian; Wuttke, Matthias; Yamamoto, Masayuki; Kashihara, Naoki; Akiyama, Masato; Kanai, Masahiro; Matsuda, Koichi; Kamatani, Yoichiro; Okada, Yukinori; Walters, Robin; Millwood, Iona Y.; Chen, Zhengming; Smith, George Davey; Barbour, Sean; Yu, Canqing; Åsvold, Bjørn Olav; Zhang, Hong; Gaunt, Tom R. (Peer reviewed; Journal article, 2021)
      Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. ...

    • Trans-fatty acids and survival in renal transplantation 

      Chandra, Anupam; Svensson, My Hanna Sofia; Åsberg, Anders; Schmidt, Erik Berg; Bjerve, Kristian S; Jenssen, Trond Geir; Hartmann, Anders; Ueland, Thor; Eide, Ivar Anders (Journal article; Peer reviewed, 2018)
      Objective High consumption of trans-fatty acids (TFAs) is associated with increased mortality. Design and methods Observational cohort study of 1.988 Norwegian renal transplant recipients with a median follow-up time ...