Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2790-2809 av 3434
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Role of the complement system in inflammatory responses to cholesterol crystals
(Doctoral thesis at NTNU;2015:78, Doctoral thesis, 2015)Komplementsystemets rolle i kolesterolkrystall induserte inflammatoriske responser Hjerte- og karsykdommer forårsaker globalt 17,3 millioner dødsfall pr. år og var med dette den ledende dødsårsaken i 2008. De vanligste ... -
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA
(Journal article; Peer reviewed, 2011)Uridine at the wobble position of tRNA is usually modified, and modification is required for accurate and efficient protein translation. In eukaryotes, wobble uridines are modified into 5-methoxycarbonylmethyluridine (mcm ... -
RORα controls inflammatory state of human macrophages
(Journal article; Peer reviewed, 2018)ROR family of nuclear receptor transcription factors forms nodes connecting metabolic and inflammatory signaling pathways. The RORα members of the family have intrinsic transcriptional activity and they are involved in ... -
Rotavirus detection in bulk stool and rectal swab specimens in children with acute gastroenteritis in Norway
(Journal article; Peer reviewed, 2017)Background Bulk stool specimens are traditionally used for rotavirus detection but may be challenging to obtain from young children. Immediate and easy sampling may however be required in different situations, such as ... -
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork
(Journal article; Peer reviewed, 2021)Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2-3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. ... -
S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes
(Peer reviewed; Journal article, 2023)Background and aims Amplification of S100A8 occurs in 10–30% of all breast cancers and has been linked to poorer prognosis. Similarly, the protein S100A8 is overexpressed in a roughly comparable proportion of breast cancers ... -
Sacred hours: Mothers´ Experiences of Skin-to-skin Contact with Their Infants Immediately After Preterm Birth
(Journal article; Peer reviewed, 2018)Objective: The aim of the present study was to investigate mothers’ own experiences of skin-to-skin contact (SSC) with their newborns immediately following moderately premature birth. Design: Mixed method, survey and ... -
Safe medication management: Evaluation and development of medication competence in registered nurses
(Doctoral theses at NTNU;2016:309, Doctoral thesis, 2016)Abstract: Safe medication management Evaluation and development of medication competence in registered nurses Aims: The paramount aims were to investigate the medication knowledge in registered nurses, to study the ... -
Safety and efficacy of plasma transfusion from exercise - trained donors in patients with early Alzheimer’s disease: protocol for the ExPlas study
(Peer reviewed; Journal article, 2022)Introduction Given that exercise training reduces the risk of developing Alzheimer’s disease (AD), induces changes in the blood composition and has widespread systemic benefits, it is reasonable to hypothesise that exercised ... -
Safety in numbers: multiple occurrences of highly similar homologs among Azotobacter vinelandii carbohydrate metabolism proteins probably confer adaptive benefits
(Journal article; Peer reviewed, 2014)Background Gene duplication and horizontal gene transfer are common processes in bacterial and archaeal genomes, and are generally assumed to result in either diversification or loss of the redundant gene copies. However, ... -
Safety of thalidomide in newly diagnosed elderly myeloma patients: a meta-analysis of data from individual patients in six randomized trials
(Journal article; Peer reviewed, 2013)Treatment with melphalan-prednisone-thalidomide improves the outcome of patients with multiple myeloma and is now considered a standard of care for patients not eligible for transplantation. However, this treatment is a ... -
Safety, productivity and predicted contribution of a surgical task-sharing programme in Sierra Leone
(Journal article; Peer reviewed, 2017) -
Saliva as a biological material in research and diagnostics. Comparative analysis of inflammatory biomarkers in saliva and blood.
(Master thesis, 2022)Abstract will be available on 2024-11-01 -
Salmon Protein Hydrolysate Potentiates the Growth Inhibitory Effect of Bicalutamide on Human Prostate Cancer Cell Lines LNCaP and PC3 by Modulating Iron Homeostasis
(Peer reviewed; Journal article, 2022)Prostate cancer is a common cause of cancer death in men. In advanced stages of prostate cancer, androgen deprivation therapy (ADT) is initiated. Despite ADT, prostate cancers invariably progress to become androgen ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
(Journal article; Peer reviewed, 2014)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Sammenhengen mellom selvrapportert fysisk aktivitet og blodtrykk, relatert til alder, kjønn og BMI
(Master thesis, 2010)Bakgrunn. Hypertensjon er blant de viktigste risikofaktorer med betydning for den globale sykdomsbelastningen. Livsstilsrelaterte faktorer er av vesentlig betydning for blodtrykksnivået. Sammenhengen mellom selvrapportert ... -
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19
(Peer reviewed; Journal article, 2023)Background Toll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exaggerated inflammatory response of innate immune cells, ... -
SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway
(Peer reviewed; Journal article, 2022)Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals ... -
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
(Peer reviewed; Journal article, 2022)Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in ... -
Saving β-Cells from Demise:Effects of in vitro Conditions and Genetic Engineering of UCP-2
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:106, Doctoral thesis, 2014)Motverking av skade på β-celler: effekt av endra in vitro-forhold og genetisk manipulering av UCP-2 Beta (β)-cellene, som produserer insulin, ligg samla i såkalla Langerhanske (L) øyer i bukspyttkjertelen. Ved diabetes er ...