Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2770-2789 av 3426
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Robustness of VMAT and 3DCRT plans toward setup errors in radiation therapy of locally advanced left-sided breast cancer with DIBH
(Journal article; Peer reviewed, 2018)Purpose The aim of our study was to evaluate and compare the robustness of treatment plans produced using the volumetric modulated arc-therapy (VMAT) and the standard three-dimensional conformal radiotherapy (3DCRT) ... -
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres
(Peer reviewed; Journal article, 2021)Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and ... -
A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis
(Peer reviewed; Journal article, 2023)Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by damage to the alveolar epithelium, leading to fibrosis and excessive accumulation of extracellular matrix in the ... -
The role of Alkyladenine DNA glycosylase (AAG) beyond canonical base excision repair
(Doctoral theses at NTNU;2021:256, Doctoral thesis, 2021) -
The role of alkylation stress response in anticancer drug resistance
(Doctoral theses at NTNU;2020:114, Doctoral thesis, 2020) -
Role of APIM in the NF-κB signaling network
(Master thesis, 2011)Decades of research have revealed that the nuclear factor-κB (NF-κB) is an important functional transcription factor which lately is also found to be constitutively active in many cancer cells such as multiple myeloma cell ... -
Role of Autoimmune Gastritis in Gastric Cancer
(Journal article; Peer reviewed, 2019)It has been known for 70 years that gastric cancer occurs mainly in a stomach with gastritis. Gastritis was previously so prevalent that it was regarded as an aging phenomenon. Since the description of Helicobacter pylori ... -
Role of autoimmunity and over stimulationfor ß-cell deficiency: Epidemiological and therapeutic perspectives
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:221, Doctoral thesis, 2009)Betydningen av diabetesantistoff og β-cellehvile for insulinproduksjonen. Diabetes omfatter flere sykdomsgrupper. Type 1 diabetes er en autoimmun sykdom, dvs. antistoff bryter ned de insulinproduserende cellene (β-cellene). ... -
Role of CD5L in control of human innate immune function
(Doctoral theses at NTNU;2018:395, Doctoral thesis, 2018)Innate immune signaling has numerous ways to sense changes in cellular metabolism to ensure appropriate response to threatening agents. For instance, cholesterol metabolites act as ligands for nuclear receptor transcription ... -
Role of enteropathogenic Escherichia coli in childhood diarrhoea in Norway
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:260, Doctoral thesis, 2007)Background Diarrhoeal diseases are among the leading causes of illness and death among children in developing countries, and do also cause considerable morbidity in industrialized countries. Enteropathogenic E. coli (EPEC), ... -
Role of Esx-3 Secretion System and Stress Response in Mycobacteria smegmatis
(Master thesis, 2015)Background: Bacteria secrets proteins to manipulate their growth environments through various secretion systems. Type VII systems are important protein secretary systems known in mycobacteria. 5 different Type VII systems ... -
Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort
(Peer reviewed; Journal article, 2023)Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ... -
The Role of IL-32 in Multiple Myeloma
(Doctoral theses at NTNU;2020:256, Doctoral thesis, 2020) -
The Role of Omics Approaches to Characterize Molecular Mechanisms of Rare Ovarian Cancers: Recent Advances and Future Perspectives
(Peer reviewed; Journal article, 2021)Rare ovarian cancers are ovarian cancers with an annual incidence of less than 6 cases per 100,000 women. They generally have a poor prognosis due to being delayed diagnosis and treatment. Exploration of molecular mechanisms ... -
Role of putative adherence factor in Shiga toxin producing Escherichia coli (STEC)
(Master thesis, 2019)Background: Infection with Shiga toxin producing Escherichia coli (STEC) may cause severe disease like haemorrhagic uremic syndrome (HUS). In addition to Shiga toxins, the ability to adhere to intestinal epithelial cells ... -
Role of the complement system in inflammatory responses to cholesterol crystals
(Doctoral thesis at NTNU;2015:78, Doctoral thesis, 2015)Komplementsystemets rolle i kolesterolkrystall induserte inflammatoriske responser Hjerte- og karsykdommer forårsaker globalt 17,3 millioner dødsfall pr. år og var med dette den ledende dødsårsaken i 2008. De vanligste ... -
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA
(Journal article; Peer reviewed, 2011)Uridine at the wobble position of tRNA is usually modified, and modification is required for accurate and efficient protein translation. In eukaryotes, wobble uridines are modified into 5-methoxycarbonylmethyluridine (mcm ... -
RORα controls inflammatory state of human macrophages
(Journal article; Peer reviewed, 2018)ROR family of nuclear receptor transcription factors forms nodes connecting metabolic and inflammatory signaling pathways. The RORα members of the family have intrinsic transcriptional activity and they are involved in ... -
Rotavirus detection in bulk stool and rectal swab specimens in children with acute gastroenteritis in Norway
(Journal article; Peer reviewed, 2017)Background Bulk stool specimens are traditionally used for rotavirus detection but may be challenging to obtain from young children. Immediate and easy sampling may however be required in different situations, such as ... -
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork
(Journal article; Peer reviewed, 2021)Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2-3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. ...