Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 2264-2283 of 3434
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Opioider for kroniske, sterke smerter - forskrives det for høye doser på blå resept?
(Master thesis, 2020)Bakgrunn: I 2008 ble det gjort endringer i blåreseptordningen slik at pasienter med kroniske sterke smerter kunne få forskrevet smertestillende legemidler av spesialist gjennom blåreseptordningen med refusjonskode -71 ... -
Oppfølging av farmakologisk behandling av pasienter med Dravet syndrom - fokus på bruk av antiepileptika og farmakokinetisk variasjon
(Master thesis, 2019)Bakgrunn: Dravet syndrom (DS) er en epileptisk encefalopati, karakterisert ved en svært alvorlig og terapirefraktær anfallssituasjon. Syndromet kjennetegnes ved en mutasjon i SCN1A, genet for spenningsstyrte natriumkanaler, ... -
Oppfølging av pasientenes legemiddelbehandling i sykehjem – en kvalitativ studie av sykepleiers opplevelser
(Master thesis, 2022)Bakgrunn: Bakgrunnen for denne masteroppgaven var å undersøke sykepleiere i sykehjem sin rolle i legemiddeloppfølgingen av pasientene. Andelen eldre i Norge er økende, i tillegg til at samhandlingsreformen førte flere av ... -
Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee.
(Peer reviewed; Journal article, 2020)Background: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). ... -
Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer
(Peer reviewed; Journal article, 2023)Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved ... -
Optimisation of Cell Based Apoptosis Assay to Investigate Gastrin- Induced Circumvention of Apoptosis in AR42J Cells
(Master thesis, 2011)This Master’s thesis is part of a research project investigating the anti-apoptotic action of gastrin. Gastrin is a peptide hormone with many characteristics. First of all, it is known for its role in regulation of gastric ... -
Optimism and sense of coherence in mothers and fathers of children with cerebral palsy participating in an intensified habilitation programme
(Journal article; Peer reviewed, 2015)Background: To describe optimism and sense of coherence in mothers and fathers of preschool children with cerebral palsy (CP), before and after participation in an intensified habilitation program. Methods: Forty-five ... -
Optimism in adults born preterm: Systematic review and individual-participant-data metaanalysis
(Peer reviewed; Journal article, 2021)Aim Preterm birth(<37 gestational weeks) is associated with numerous adversities, however, data on positive developmental outcomes remain limited. We examined if preterm and term born(≥37 gestational weeks) adults differ ... -
Optimization and Validation of Digital Droplet PCR assays for Detection of circulating tumor DNA in serum/plasma from patients with Multiple Myeloma
(Master thesis, 2017)Circulating tumor DNA (ctDNA) has been shown as a promising biomarker for monitoring several tumor types. We want to study the use of ctDNA in monitoring multiple myeloma, by use of digital droplet PCR (ddPCR). The objective ... -
Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
(Journal article; Peer reviewed, 2010)Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in ... -
Optimization of fluorescence staining of zinc and related proteins (ZIP1 and RREB1) in human prostate
(Master thesis, 2020)Abstract Prostate cancer (PCa) is one of the causes of cancer related deaths in men. The current clinical tools for its diagnosis have limitations that makes it unreliable. Thus, there is need for alternative procedures ... -
Optimization of oil-in-water nanoemulsions for tumor targeting and molecular dynamic contrast enhanced MRI
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:350, Doctoral thesis, 2013) -
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
(Peer reviewed; Journal article, 2023)In vitro determination of hemolytic properties is a common and important method for preliminary evaluation of cytotoxicity of chemicals, drugs, or any blood-contacting medical device or material. The method itself is ... -
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue
(Peer reviewed; Journal article, 2022)MALDI MS imaging (MSI) is a powerful analytical tool for spatial peptide detection in heterogeneous tissues. Proper sample preparation is crucial to achieve high quality, reproducible measurements. Here we developed an ... -
Optimized synthesis of polyacrylic acid-coated magnetic nanoparticles for high-efficiency DNA isolation and size selection
(Peer reviewed; Journal article, 2023)Solid-phase reversible immobilization (SPRI) bead technology is widely used in molecular biology for convenient DNA manipulation. However, commercial SPRI bead kits lack cost advantages and flexibility. It is, therefore, ... -
Optimizing non-invasive respiratory support for preterm infants
(Doctoral theses at NTNU;2024:55, Doctoral thesis, 2024)Optimizing non-invasive respiratory support for preterm infants Optimizing non-invasive breathing support for preterm infants with respiratory distress syndrome (RDS) includes different treatment strategies and perspectives: ... -
Optogenetic Dissection of Entorhinal-Hippocampal Space Circuit
(Master thesis, 2013)Spatial representation system of brain is comprised of place cells located in the hippocampus and grid cells, head-direction cells, and border cells found in the medial entorhinal cortex. There is a prominent circuitry ... -
Oral health history in children referred to a child advocacy center in Norway
(Peer reviewed; Journal article, 2022)Background Some suspected child victims of physical or sexual abuse undergo dental forensic examinations at child advocacy centers (CACs) in Norway. Their oral health history has not previously been studied. Objective This ... -
Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis
(Journal article; Peer reviewed, 2019)Background Observational studies examining the association between oral health and juvenile idiopathic arthritis (JIA) among children and adolescents have reported inconsistent findings. The aims of this systematic review ...