Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2129-2148 av 3443
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Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype
(Peer reviewed; Journal article, 2019)Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations ... -
Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove
(Journal article; Peer reviewed, 2014)Heat-shock protein 70 (Hsp70)–peptide complexes are involved in MHC class I- and II-restricted antigen presentation, enabling enhanced activation of T cells. As shown previously, mammalian cytosolic Hsp70 (Hsc70) molecules ... -
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
(Journal article; Peer reviewed, 2018)Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. ... -
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
(Peer reviewed; Journal article, 2020)MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient ... -
MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy
(Journal article; Peer reviewed, 2015)In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ... -
MYC dysregulation in the progression of multiple myeloma
(Journal article; Peer reviewed, 2019) -
Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition
(Journal article; Peer reviewed, 2014)The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation ... -
Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium
(Peer reviewed; Journal article, 2020)Mycobacterium avium (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have ... -
Mycoplasma genitalium and sexual behaviour: A cross-sectional study of students in Trondheim, Norway
(Master thesis, 2016)Background: Screening of Mycoplasma genitalium is not recommended in Norway. Our objective was to investigate the prevalence of M. genitalium and associated sexual habits among students in Trondheim, Norway. Methods: In ... -
Mycoplasma genitalium Macrolide-resistance and treatment options
(Doctoral theses at NTNU;2020:360, Doctoral thesis, 2020) -
Mycotic abdominal aortic aneurysm caused by Borrelia afzelii: a case report
(Peer reviewed; Journal article, 2022)Background Inflammatory aneurysms and mycotic aneurysms make up a minority of abdominal aortic aneurysms. Mainly autoimmune mechanisms are proposed in the pathogenesis of inflammatory aneurysms, and it is not routine ... -
Myeloma-derived extracellular vesicles mediate HGF/c-Met signaling in osteoblast-like cells
(Journal article; Peer reviewed, 2019)Multiple myeloma is an incurable cancer of antibody-producing plasma cells. Hepatocyte growth factor (HGF), a cytokine aberrantly expressed in half of myeloma patients, is involved in myeloma pathogenesis by enhancing ... -
Mykpreservering og klinisk anatomi
(Peer reviewed; Journal article, 2022)Mykpreservering av legemer kan være en stor mulighet i anatomisk videreutdanning av kirurger og andre klinikere. Universitetene kan legge til rette, men hvem tar regningen? De siste årene har anatomiske avdelinger i ... -
Myocardial function in premature infants: a longitudinal observational study
(Journal article; Peer reviewed, 2013)Objectives: Gestational and chronological age may have an impact on myocardial function. We studied the longitudinal changes of the atrioventricular tissue Doppler velocities in premature infants through the neonatal ... -
N-3 Polyunsaturated Fatty Acids in Health and Disease - Clinical and Molecular Aspects
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:119, Doctoral thesis, 2009) Omega-3 Flerumettede Fettsyrer og Helse – Kliniske og Molekylære Aspekter Omega-3 fettsyrer tilhører gruppen essensielle fettsyrer. Det betyr at vi ikke kan lage dem selv, men at de må tilføres gjennom kosten, ... -
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
(Journal article; Peer reviewed, 2017)Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ... -
N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients
(Peer reviewed; Journal article, 2022)Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting one-third ... -
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
(Peer reviewed; Journal article, 2020)Background More than 170 post-transcriptional RNA modifications regulate the localization, processing and function of cellular RNAs, and aberrant RNA modifications have been linked to a range of human diseases. The RNA ... -
Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host TMPRSS2
(Peer reviewed; Journal article, 2021)SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges ... -
Nanomaterials - Toxic or Therapeutic?
(Master thesis, 2020)Nanomaterialer (NMer), slik som nedbrytningsprodukter av plast og konstruerte medikament leveringspartikler, både slippes ut i miljøet og administreres til mennesker i økende grad. Dette gjør at man stiller spørsmål ved ...