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Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population – the Nord-Trøndelag Health Study
(Peer reviewed; Journal article, 2020)Persons with rheumatoid arthritis (RA) or diabetes have increased risk of cardiovascular disease (CVD) and higher death rates compared to the general population. This study used data from the population-based Nord-Trøndelag ... -
MotifLab: a tools and data integration workbench for motif discovery and regulatory sequence analysis
(Journal article; Peer reviewed, 2013)Background: Traditional methods for computational motif discovery often suffer from poor performance. In particular, methods that search for sequence matches to known binding motifs tend to predict many non-functional ... -
Motivational Interviewing and Medication Review in Coronary Heart Disease (MIMeRiC): Intervention Development and Protocol for the Process Evaluation
(Journal article; Peer reviewed, 2018)Background: Trials of complex interventions are often criticized for being difficult to interpret because the effects of apparently similar interventions vary across studies dependent on context, targeted groups, and the ... -
Motivational interviewing and medication review in coronary heart disease (MIMeRiC): Protocol for a randomized controlled trial investigating effects on clinical outcomes, adherence and quality of life
(Journal article; Peer reviewed, 2018)Background: Preventive treatment goals for blood pressure and cholesterol levels continue to be unmet for many coronary patients. The effect of drug treatment depends on both its appropriateness and the patients’ adherence ... -
Motoriske problemer hos tenåringer født for tidlig eller for små : oversikt fra en doktorgradsavhandling
(Journal article; Peer reviewed, 2011) -
MR Evaluation of Breast Cancer Patients with a Poor Prognosis
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:01, Doctoral thesis, 2011)Background and Objectives A major shift is expected in clinical cancer treatment over the next few decades as we start to move away from currently practiced, population-based approaches to more personalized medicine. One ... -
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
(Peer reviewed; Journal article, 2020)The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expression are associated with carcinogenesis and cancer treatment outcomes. ... -
MRI in the Assessment of TMJ-Arthritis in Children with JIA; Repeatability of a Newly Devised Scoring System
(Peer reviewed; Journal article, 2021)Rationale and Objectives: The temporomandibular joint (TMJ) is commonly involved in children with juvenile idiopathic arthritis. The diagnosis and evaluation of the disease progression is dependent on medical imaging. The ... -
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity
(Journal article; Peer reviewed, 2015)Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ... -
MRI-based radiomic signatures for pretreatment prognostication in cervical cancer
(Peer reviewed; Journal article, 2023)Background Accurate pretherapeutic prognostication is important for tailoring treatment in cervical cancer (CC). Purpose To investigate whether pretreatment MRI-based radiomic signatures predict disease-specific ... -
MRPL28: A New Candidate Gene for Aerobic Capacity
(Master thesis, 2015)Large-scale epidemiological studies demonstrate that aerobic capacity, measured as maximal oxygen uptake (VO2max), is the single best predictor for future cardiovascular mortality in both healthy individuals and patients ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
(Peer reviewed; Journal article, 2020)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ... -
MS-proteomics provides insight into the host responses towards alginate microspheres
(Journal article; Peer reviewed, 2022)Protein adsorption to biomaterial surfaces is considered a determining factor for the host response. Here we detail the protein adsorption profiles of alginate hydrogel microspheres relevant for cell therapy using mass ... -
MTHFR C677T and A1298C polymorphism’s effect on risk of colorectal cancer in Lynch syndrome
(Peer reviewed; Journal article, 2023)Lynch syndrome (LS) is characterised by an increased risk of developing colorectal cancer (CRC) and other extracolonic epithelial cancers. It is caused by pathogenic germline variants in DNA mismatch repair (MMR) genes or ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
(Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
(Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
(Journal article, 2014)Background: Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
(Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
(Peer reviewed; Journal article, 2022)COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ...