Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1538-1557 av 3434
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Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword
(Peer reviewed; Journal article, 2022)Coronavirus disease 2019, or COVID-19, is a major challenge facing scientists worldwide. Alongside the lungs, the system of organs comprising the GI tract is commonly targeted by COVID-19. The dysbiotic modulations in the ... -
Immunoregulatory roles of chemokines and epithelium in inflammatory bowel disease - CCL20 in mucosa, human colonoids and peripheral blood mononuclear cells
(Doctoral theses at NTNU;2020:382, Doctoral thesis, 2020)Inflammatory bowel diseases (IBD) are characterized by chronic inflammation in the intestinal tract, which leads to substantial cost for the individual and for society. The pathogenesis is described as an inflammation ... -
Immunotherapy in inflammatory bowel disease: Novel and emerging treatments
(Peer reviewed; Journal article, 2018)Inflammatory bowel disease (IBD) is a chronic disabling inflammatory process that affects young individuals, with growing incidence. The etiopathogenesis of IBD remains poorly understood. A combination of genetic and ... -
Impact of 2015 Earthquakes on a local hospital in Nepal: A Prospective Hospital-based Study
(Journal article; Peer reviewed, 2018)Introduction Natural disasters pose a great challenge to the health systems and individual health facilities. In low-resource settings, disaster preparedness systems are often limited and not been well described. Two ... -
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3
(Journal article; Peer reviewed, 2019)Purpose The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity per se. Against this background, we investigated the impact of FTO allele ... -
Impact of acetyltransferases in B cell development
(Master thesis, 2020)Abstract Histone acetylation is a crucial mechanism involved in several cellular functions, including embryogenesis, DNA repair, cell cycle regulation, neurogenesis, and lymphocyte development. Acetyltransferases are the ... -
The impact of age on rectal cancer treatment, complications and survival
(Peer reviewed; Journal article, 2022)Background The number of older patients with rectal cancer is increasing. Treatment outcome discrepancies persist, despite similar treatment guidelines. To offer the oldest patients optimal individually adjusted care, ... -
Impact of altered Alkyladenine DNA glycosylase expression and catalytical activity on cortical cytoarchitecture
(Master thesis, 2022)Abstract will be available on 2027-06-02 -
The impact of clinical experience on working tasks and job-related stress: a survey among 1032 Norwegian GPs
(Peer reviewed; Journal article, 2022)Background General practice is a generalist discipline fraught with complexity. For inexperienced physicians, it may be demanding to get to grips with the clinical challenges. The purpose of this article is to describe ... -
Impact of dietary fat quantity and quality in type 2 diabetes with emphasis on marine n-3 fatty acids
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:83, Doctoral thesis, 2007)Doktoravhandlingen bygger på tre kliniske studier av personer med type 2 diabetes. Artikkel 1. Hensikten var å undersøke effekter av en 3-dagers intervensjon med fettfattig kost. Blodsukker, insulinfølsomhet, fettstoffer ... -
Impact of DNA double-strand break response factors on B and T lymphocyte development
(Doctoral theses at NTNU;2022:224, Doctoral thesis, 2022)Sammendrag på norsk Virkningen av DNA-dobbeltrådbrudd responsfaktorer på B- og T-lymfocytt utvikling De mest cytotoksiske DNA-skadene i en celle er forårsaket av brudd på dobbelttrådet DNA (DSB). NHEJ er en essensiell ... -
Impact of DNA glycosylase activity on gene expression
(Master thesis, 2021)Abstract will be available on 2024-05-30 -
Impact of Food-Based Weight Loss Interventions on Gut Microbiome in Individuals with Obesity: A Systematic Review
(Peer reviewed; Journal article, 2022)The observation that the gut microbiota is different in healthy weight as compared with the obese state has sparked interest in the possible modulation of the microbiota in response to weight change. This systematic review ... -
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study
(Peer reviewed; Journal article, 2020)Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ... -
Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination
(Peer reviewed; Journal article, 2020)Background HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect ... -
Impact of job adjustment, pain location and exercise on sick leave due to lumbopelvic pain in pregnancy: a longitudinal study
(Journal article; Peer reviewed, 2019)Objective: To identify factors associated with sick leave due to lumbopelvic pain (LPP) in pregnancy. Design: Prospective cohort study using participants from a randomized controlled trial (RCT) designed to study the ... -
Impact of KRAS and BRAF mutations on treatment efficacy and survival in high-grade gastroenteropancreatic neuroendocrine neoplasms
(Peer reviewed; Journal article, 2023)High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact ... -
Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
(Peer reviewed; Journal article, 2021)Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal metastasis ... -
The impact of longitudinal surveillance of individuals with cerebral palsy in Norway; a 20-year quality registry and follow-up program perspective
(Peer reviewed; Journal article, 2023)The Norwegian Quality and Surveillance Registry for Cerebral Palsy (NorCP) has systematically collected data on individuals with cerebral palsy (CP) and been a driver of knowledge dissemination for over 20 years. NorCP ... -
Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: individual participant data meta-analysis
(Journal article; Peer reviewed, 2019)Objectives: To identify if maternal educational attainment is a prognostic factor for gestational weight gain (GWG), and to determine the differential effects of lifestyle interventions (diet based, physical activity based ...