Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1226-1245 av 3554
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Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia
(Peer reviewed; Journal article, 2020)Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other ... -
Fetal molding examined with transperineal ultrasound and associations with position and delivery mode
(Journal article; Peer reviewed, 2020)Background To accommodate passage through the birth canal, the fetal skull is compressed and reshaped, a phenomenon known as molding. The fetal skull bones are separated by membranous sutures that facilitate compression ... -
FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis
(Journal article; Peer reviewed, 2017)Purpose Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer. We aimed to describe FGD5 copy number change ... -
Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo
(Journal article; Peer reviewed, 2017)Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of ... -
Finding gene regulatory network candidates using the gene expression knowledge base
(Journal article; Peer reviewed, 2014)Background: Network-based approaches for the analysis of large-scale genomics data have become well established. Biological networks provide a knowledge scaffold against which the patterns and dynamics of ?omics? data can ... -
Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys
(Journal article; Peer reviewed, 2018)Background Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current ... -
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases
(Journal article; Peer reviewed, 2017)Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine JIA categories and improve the current classification ... -
Finnes det medikamenter som kan forbedre den kognitive funksjonen hos friske individer?: En litteraturstudie av potensielt kognisjonsfremmende medikamenter
(Master thesis, 2010)Bakgrunn. Det er stor faglig og kommersiell interesse rundt medikamenter som kan virke kognisjonsfremmende hos friske individer. Det finnes flere medikamenter som i dag brukes i behandling av ulike sykdomstilstander, og ... -
The first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylation
(Peer reviewed; Journal article, 2021)DNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa. This DNA modification was first found in nuclear ... -
The first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylation
(Journal article; Peer reviewed, 2021)DNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa. This DNA modification was first found in nuclear ... -
First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study
(Journal article; Peer reviewed, 2015)Hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal morbidity. The goal of this study was to evaluate the potential of metabolomics to predict preeclampsia and gestational ... -
First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—the randomised METIMMOX trial
(Journal article; Peer reviewed, 2024)Background We evaluated first-line treatment of metastatic microsatellite-stable colorectal cancer with short-course oxaliplatin-based chemotherapy alternating with immune checkpoint blockade. Methods Patients were ... -
"Five-year changes in population newborn health associated with new preventive services in targeted risk-group pregnancies"
(Journal article; Peer reviewed, 2019)Backgrounds: In 2009, the prevention service “Familieambulatoriet” (FA) was established in three pilot hospital areas offering psychosocial support and health monitoring to parents in high risk regarding mental health and ... -
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
(Journal article; Peer reviewed, 2023)Background: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 ... -
Flow analysis of RANK expression on myeloid cells and identification of bone marrow cells expressing IL-32 in multiple myeloma patients
(Master thesis, 2016)Multiple myeloma is the second most common hematological cancer worldwide, characterized by an increased expansion of malignant plasma cells in the bone marrow, organ dysfunction, immunodeficiency and bone erosion. Nearly ... -
Flow-cytometric analysis of autophagy in activated primary human CD4+ T cells
(Master thesis, 2015)The hallmark of an immune response to Mycobacterium tuberculosis is granuloma formation. CD4+Th1 cells are of central importance in anti-mycobacterial immunity by way of producing effector IFN-γ and TNF-α cytokines that ... -
Food intake by Patient-Generated Subjective Global Assessment (PG-SGA) corresponds to energy and protein intake as well as weight change in patients with advanced cancer
(Journal article; Peer reviewed, 2019)Background & aims The aim of this study was to test how well the Patient-Generated Subjective Global Assessment (PG-SGA) question about food intake correlates with a well-established measurement of food intake. Furthermore, ... -
”For this one, let me take the risk”: why surgical staff continued to perform caesarean sections during the 2014–2016 Ebola epidemic in Sierra Leone
(Journal article; Peer reviewed, 2019)Introduction: Routine health service provision decreased during the 2014-2016 Ebola virus disease (EVD) outbreak in Sierra Leone, while caesarean section (CS) rates at public hospitals did not. It is unknown what made ... -
Forekomst av komplikasjoner ved gjenopprettelse av normal tarmkontinuitet etter avlastende stomi ved St. Olavs Hospital
(Master thesis, 2016)Bakgrunn: Å gjenopprette normal tarmkontinuitet etter avlastende stomier er beheftet med komplikasjoner. I denne studien ønsket vi å sammenligne resultatene ved St. Olavs hospital fra 2012 til 2015 med andre materialer, ...