Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 3436-3455 av 3589
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UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines
(Journal article; Peer reviewed, 2021)Metabolic rewiring is one of the indispensable drivers of epithelial-mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
(Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ... -
Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential
(Journal article; Peer reviewed, 2019)Using a lepirudin-based human whole blood model, we evaluated the initial inflammatory and coagulation responses of dense and porous ultrapure (<50 endotoxin units/grams) cellulose nanofibrils (CNF), of carboxylated grade. ... -
Ultrasound &prediction of prolonged labor
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:242, Doctoral thesis, 2013) -
Ultrasound and microbubble-enhanced therapy of Gastrointestinal tumors using conventional cytotoxic drugs in preclinical and clinical settings
(Doctoral theses at NTNU;2024:94, Doctoral thesis, 2024)Pancreatic ducal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a very short life expectancy. Together with late diagnosis and aggressive biology, chemoresistance is one important cause of poor survival. ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
(Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ... -
Ultrasound examination of the pelvic floor during active labor: A longitudinal cohort study
(Journal article; Peer reviewed, 2023)Introduction: There is limited evidence about changes in the pelvic floor during active labor. We aimed to investigate changes in hiatal dimensions during the active first stage of labor and associations with fetal descent ... -
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
(Journal article; Peer reviewed, 2017)Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ... -
UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
(Peer reviewed; Journal article, 2021)Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of ... -
Understanding and preventing Mycobacterium avium infections
(Doctoral theses at NTNU;2018:178, Doctoral thesis, 2018)Mycobacterium avium (Mav) complex (MAC) is a group of slow growing, environmental opportunist pathogens, that have been associated with animal and human infections. Mav is one of the species belonging to MAC, which can be ... -
Understanding cellular responses induced by gastrin in gastric adenocarcinoma cells
(Doctoral thesis at NTNU;2015:316, Doctoral thesis, 2015)Sammendrag: Hormonet gastrin spiller en sentral rolle i regulering av magesyre og i utvikling og vedlikehold av normal mageslimhinne. Gastrin har i tillegg en generell vekstfremmende effekt både på normale celler og på ... -
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
(Journal article; Peer reviewed, 2011)Cytotoxicity of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FdUrd) due to DNA fragmentation during DNA repair has been proposed as an alternative to effects from thymidylate synthase (TS) inhibition or RNA incorporation. ... -
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
(Journal article; Peer reviewed, 2019)The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is ... -
Unravel the Local Complexity of Biological Environments by MALDI Mass Spectrometry Imaging
(Peer reviewed; Journal article, 2021)Classic metabolomic methods have proven to be very useful to study functional biology and variation in the chemical composition of different tissues. However, they do not provide any information in terms of spatial ... -
Unraveling the role of LSD1 in murine intestinal epithelial development
(Bachelor thesis, 2019)Background: The intestinal epithelium is a vital organ that absorbs nutrients and water from luminal contents and provide protection against pathogens and chemicals through the stimulation of the immune system and secretion ... -
Unrecognized viral infections and chromosome abnormalities as a cause of fetal death – examination with fluorescence in situ hybridization, immunohistochemistry and polymerase chain reaction
(Journal article; Peer reviewed, 2017)Fifteen to 50% of fetal deaths remain unexplained after post-mortem examination depending on inclusion criteria and classification systems. Our aim was to examine a selection of unexplained fetal deaths in order to investigate ... -
Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals
(Journal article; Peer reviewed, 2017)Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource ... -
Update on genetic predisposition to colorectal cancer and polyposis
(Journal article; Peer reviewed, 2019)The present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary ... -
Updating risk management recommendations to limit exposure of non-target Lepidoptera of conservation concern in protected habitats to Bt-maize pollen
(Journal article; Peer reviewed, 2015)Using mathematical modelling, the EFSA GMO Panel has previously quantified the risk to non-target (NT) Lepidoptera of conservation concern, potentially occurring within protected habitats, associated with the ingestion of ... -
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG
(Journal article; Peer reviewed, 2017)Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ...