Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 3019-3038 av 3438
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Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
(Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ... -
A systematic review examining nutrition support interventions in patients with incurable cancer
(Peer reviewed; Journal article, 2019)Purpose Recent guidelines by the European Society for Clinical Nutrition and Metabolism (ESPEN) have advocated increased attention to nutritional support in all patients with cancer; however, little is known about the ... -
Systematic review: predictive value of organoids in colorectal cancer
(Peer reviewed; Journal article, 2023)While chemotherapy alone or in combination with radiotherapy and surgery are important modalities in the treatment of colorectal cancer, their widespread use is not paired with an abundance of diagnostic tools to match ... -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
(Peer reviewed; Journal article, 2020)Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ... -
Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study
(Peer reviewed; Journal article, 2023)Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ... -
Systemic inflammation persists the first year after mild traumatic brain injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study
(Peer reviewed; Journal article, 2020)Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate immune activation are unknown. We determined ... -
Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation
(Peer reviewed; Journal article, 2017)PURPOSE. To assess the association between systemic levels of inflammation-associated proteins and severe retinopathy of prematurity (ROP) in extremely preterm infants. METHODS. We collected whole blood on filter paper on ... -
Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention
(Peer reviewed; Journal article, 2023)Background Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondheim ... -
Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
(Peer reviewed; Journal article, 2023)Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ... -
Systems Medicine: From Modeling Systems Perturbations to Predicting Drug Synergies
(Doctoral thesis at NTNU;2016:55, Doctoral thesis, 2016)Computational approaches to systems biology and systems medicine enable the study of systems properties that emerge from integrating knowledge about complex interactions, such as in the study of cancer cell phenotypes ... -
T cell subsets in bronchoalveolar lavage fluid in sarcoidosis and other diffuse parenchymal lung diseases
(Doctoral thesis at NTNU;2015:49, Doctoral thesis, 2015)Slimhinnen i luftveiene og lungene er kontinuerlig eksponert for partikler, støv og en stor mengde mikrober fra omgivelsene. Ufarlige mikrober og partikler fjernes med minst mulig betennelsesreaksjon i vevet, slik at ... -
T.M. Gundem og medarbeidere svarer
(Journal article; Peer reviewed, 2020) -
T1 bladder cancer in Norway: treatment and survival
(Peer reviewed; Journal article, 2020)Aim: Evaluation of treatment and survival of pT1 stage (T1) bladder cancer (BC) patients diagnosed with transitional cell carcinoma of the urinary bladder in Norway. Material and methods: According to the Cancer Registry ... -
Tailored microfluidic platforms for advanced neurobiology, neuroengineering and electrophysiology
(Doctoral theses at NTNU;2019:135, Doctoral thesis, 2019) -
TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy
(Doctoral theses at NTNU;2024:74, Doctoral thesis, 2024)TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy Multiple myeloma is a hematological malignancy characterized by accumulation of malignant plasma cells in the bone marrow. This can lead to uncontrolled ... -
TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma
(Peer reviewed; Journal article, 2022)Objective Multiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of resistance and minimal residual disease remain challenging in the ... -
Tar pasienter legemidler som forskrevet?
(Master thesis, 2009) -
Targeted correlative light and electron microscopy in the study of host-pathogen interactions
(Doktoravhandlinger ved NTNU;2018:89, Doctoral thesis, 2018)Abstract Tuberculosis (TB) and HIV are the two deadliest infectious diseases in the world today. 1,8 million people died from TB in 2015, 400.000 of which were HIV positive. Drug resistant TB strains are rapidly spreading, ... -
Targeted Next Generation sequencing identified novel gene variants involved in hereditary colorectal cancer
(Master thesis, 2015)cancer (CRC) is one of the most common types of cancer both worldwide and in Norway. Risk factors and mechanisms contributing to the disease are among dietary and lifestyle and somatic and inherited mutations. CRC is ... -
Targeted next-generation sequencing identified novel mismatch repair risk-variants involved in hereditary colorectal cancer
(Master thesis, 2015)Colorectal cancer (CRC) is the third most common malignancy worldwide, with over 1 million new cases annually. Around 30% of cases are believed to be familial with causal genetic alterations. However, fewer than 10% of ...