Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. 

      Zub, Kamila Anna; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Demirovic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders; Jensen, Ole Nørregaard; Slupphaug, Geir (Journal article; Peer reviewed, 2015)
      Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most commonly used chemotherapeutic ...

    • Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue 

      Subbannayya, Yashwanth; Pinto, Sneha M. (Journal article, 2021)
      Loss of cell differentiation is a hallmark for the progression of oral squamous cell carcinoma (OSCC). Archival Formalin-Fixed Paraffin-Embedded (FFPE) tissues constitute a valuable resource for studying the differentiation ...

    • Molecular basis of mycobacterial survival in macrophages 

      Awuh, Jane Atesoh; Flo, Trude Helen (Journal article; Peer reviewed, 2017)
      Macrophages play an essential role in the immune system by ingesting and degrading invading pathogens, initiating an inflammatory response and instructing adaptive immune cells, and resolving inflammation to restore ...

    • Molecular biomarkers of prostate cancer 

      Hansen, Ailin Falkmo (Doctoral theses at NTNU;2017:337, Doctoral thesis, 2017)

    • The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Venizelos, Andreas; Elvebakken, Hege; Perren, Aurel; Nikolaienko, Oleksii; Deng, Wei; Lothe, Inger Marie Bowitz; Couvelard, Anne; Hjortland, Geir Olav; Sundlöv, Anna; Svensson, Johanna; Garresori, Herish; Kersten, Christian; Hofsli, Eva; Detlefsen, Sönke; Krogh, Merete; Sørbye, Halfdan; Knappskog, Stian (Peer reviewed; Journal article, 2021)
      High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare but have a very poor prognosis and represent a severely understudied class of tumours. Molecular data for HG GEP-NEN are limited, and ...

    • Molecular Characterization of the Extracellular Matrix Protein TINAGL1 in Breast Cancer 

      Sarlak, Saharnaz (Master thesis, 2014)
      Previous work in this group using Mass Spectrometry (MS) analysis of extracellular matrix (ECM) from breast tumor samples at different tumor stages, had reported that TINAGL1 is highly expressed during breast carcinogenesis ...

    • Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. 

      Benschop, Kimberley; Broberg, Eeva; Hodcroft, E; Schmitz, D; Albert, Jan; Baicus, A; Bailly, Jean-Luc; Baldvinsdottir, Gudrun; Berginc, N; Blomqvist, S; Böttcher, S; Brytting, M; Bujaki, Erika; Cabrerizo, Maria; Celma, Cristina; Cinek, Ondrej; Claas, Eric CJ; Cremer, Jeroen; Dean, Jonathan; Dembinski, Jennifer Lynn; Demchyshyna, Iryna; Diedrich, Sabine; Dudman, Susanne Gjeruldsen; Dunning, Jake; Dyrdak, Robert; Emmanouil, Mary; Farkas, Agnes; De Gascun, Cillian; Fournier, Guillaume; Georgieva, Irina; Gonzalez-Sanz, Ruben; van Hooydonk-Elving, Jolanda; Jääskeläinen, A. J.; Jancauskaite, Ruta; Keeren, Kathrin; Fischer, Thea Kølsen; Krokstad, Sidsel; Nikolaeva–Glomb, Lubomira; Novakova, Ludmila; Midgley, SE; Mirand, Audrey; Molenkamp, Richard; Morley, Ursula; Mossong, Joël; Muralyte, Svajune; Murk, Jean-Luc; Nguyen, Trung; Nordbø, Svein Arne; Österback, Riikka; Pas, Suzan; Pellegrinelli, Laura; Pogka, Vassiliki; Prochazka, Birgit; Rainetova, Petra; Van Ranst, Marc; Roorda, Lieuwe; Schuffenecker, Isabelle; Schuurman, Rob; Stoyanova, Asya; Templeton, Kate E.; Verweij, Jaco J.; Voulgari-Kokota, Androniki; Vuorinen, Tytti; Wollants, Elke; Wolthers, Katja; Zakikhany, Katherina; Neher, Richard; Harvala, Heli; Simmonds, Peter (Journal article; Peer reviewed, 2021)
      In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most ...

    • Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer 

      Lesurf, Robert; Aure, Miriam Ragle; Mørk, Hanne Håberg; Vitelli, Valeria; Lundgren, Steinar; Børresen-Dale, Anne-Lise; Kristensen, Vessela N.; Wärnberg, Fredrik; Hallett, Michael; Sørlie, Therese (Peer reviewed; Journal article, 2016)
      Breast cancer consists of at least five main molecular “intrinsic” subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of ...

    • Molecular Mechanisms of NLRP3 Inflammasome Activation by Crystalline Material 

      Samstad, Eivind Ottersen (Doctoral thesis at NTNU;2015:18, Doctoral thesis, 2015)

    • Molecular mechanisms of the proliferative response to the hormone gastrin 

      Steigedal, Tonje Strømmen (Doktoravhandlinger ved NTNU, 1503-8181; 2009:256, Doctoral thesis, 2009)
        Molekylære mekanismer til den proliferative responsen til hormonet gastrin Menneskekroppen består av mange ulike celletyper som alle inneholder det samme arvemateriealet (DNA) som koder for mellom 20.000 og 30.000 ...

    • Molecular Methods for Typing of Streptococcus agalactiae with Special Emphasis on the Development and Validation of a Multi-Locus Variable Number of Tandem Repeats Assay (MLVA) 

      Radtke, Andreas (Doktoravhandlinger ved NTNU, 1503-8181; 2012:28, Doctoral thesis, 2012)
      Molekylære metoder for typing av Streptococcus agalactiae med særlig vektlegging av utvikling og validering av et multi-locus variable number of tandem repeats assay (MLVA) Sammendraget: Streptococcus agalactiae eller ...

    • Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma 

      Røe, Oluf Dimitri; Szulkin, Adam; Anderssen, Endre; Flatberg, Arnar; Sandeck, Helmut; Amundsen, Tore; Erlandsen, Sten Even; Dobra, Katalin; Sundstrøm, Stein Harald (Journal article; Peer reviewed, 2012)

    • Molecular Subtypes and Survival in a Historic Cohort of Women with Breast Cancer 

      Engstrøm, Monica Jernberg (Doctoral thesis at NTNU;2015:56, Doctoral thesis, 2015)
      Molekylære subtyper og overlevelse i en historisk kohort av kvinner med brystkreft Målsetningen med studiene bak denne avhandlingen var å bidra til bedre klassifisering av brystkreft i prognostiske grupper. Arbeidet er ...

    • Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences 

      Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe (Journal article; Peer reviewed, 2016)
      Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 ...

    • Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients 

      Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. (Peer reviewed; Journal article, 2013)
      Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ...

    • Molecular tools and model systems for studying inflammasome activation 

      Kim, Haelin (Master thesis, 2019)
      Upon cellular stress or invasion by pathogens such as Mycobacterium tuberculosis (Mtb), inflammasomes are activated as an innate immune response, an important host-defense mechanism to resist pathogens. Activation of NLRP3 ...

    • Monitoring deep inspiration breath hold for left-sided localized breast cancer radiotherapy with an in-house developed laser distance meter system 

      Jensen, Christer André; Abramova, Tatiana Mikhailovna; Frengen, Jomar; Lund, Jo-Åsmund (Journal article; Peer reviewed, 2017)
      Deep inspiration breath hold (DIBH) in left‐sided breast cancer radiotherapy is a technique to reduce cardiac and pulmonary doses while maintaining target coverage. This study aims at evaluating an in‐house developed DIBH ...

    • Monitoring multiple myeloma by quantification of recurrent mutations in serum 

      Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)
      Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ...

    • Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. 

      Bjørås, Karine; Sousa, Mirta; Sharma, Animesh; Fonseca, Davi de Miranda; Søgaard, Caroline Danielsen; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2017)
      Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision ...

    • Monitoring protein synthesis and degradation by metabolic AHA labeling and click chemistry based detection 

      Gärtner, Hanne Holm (Master thesis, 2014)
      The proteome determines the biochemical reactions that can be carried out by the cell, and is thus highly dynamic and tightly regulated by protein synthesis and degradation for adaption to environmental cues and cellular ...