Browsing Institutt for klinisk og molekylær medisin by Title

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    • Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment 

      Flak, Marianne Møretrø; Hol, Haakon Ramsland; Hernes, Susanne M S; Chang, Linda; Ernst, Thomas; Engvig, Andreas; Bjuland, Knut Jørgen; Madsen, Bengt-Ove; Lindland, Elisabeth Margrete Stokke; Knapskog, Anne Brita; Ulstein, Ingun; Lona, Trine Eli.B.; Skranes, Jon Sverre; Løhaugen, Gro (Journal article; Peer reviewed, 2018)
      In this cross-sectional study, we sought to describe cognitive and neuroimaging profiles of Memory clinic patients with Mild Cognitive Impairment (MCI). 51 MCI patients and 51 controls, matched on age, sex, and socio-economic ...

    • Cognitive Rehabilitation for Neurocognitive Late Effects in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Feasibility and Case-Series Study 

      Egset, Kaja Solland; Weider, Siri; Stubberud, Jan Egil; Hjemdal, Odin; Ruud, Ellen; Hjort, Magnus Aassved; Eilertsen, Mary-Elizabeth B; Sund, Anne Mari; Røkke, Magnhild Eitrem; Reinfjell, Trude (Peer reviewed; Journal article, 2021)
      Neurocognitive late effects following the diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) commonly include impaired executive functions (EFs), with negative consequences for one’s health-related ...

    • Cognitive rehabilitation in paediatric acquired brain injury—A 2-year follow-up of a randomised controlled trial 

      Sargénius, Hanna Lovise; Andersson, Stein; Haugen, Ingvild; Hypher, Ruth Elizabeth; Brandt, Anne Elisabeth; Finnanger, Torun Gangaune; Rø, Torstein Baade; Risnes, Kari; Stubberud, Jan Egil (Peer reviewed; Journal article, 2023)
      Background: Goal management training (GMT), a metacognitive rehabilitation method that has been demonstrated to improve executive function (EF) in adults with acquired brain injury (ABI), could potentially be effective for ...

    • Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study 

      Eriksen, Guro Falk; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Kirkevold, Øyvind; Bergh, Sverre; Hjelstuen, Anne Kristine; Rolfson, Darryl; Jordhøy, Marit Slaaen (Peer reviewed; Journal article, 2022)
      Cognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients ≥65 years referred for radiotherapy (RT), we aimed to ...

    • A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer 

      Dalsgaard, Sofie Bünemann; Würtz, Else Toft; Hansen, Johnni; Røe, Oluf Dimitri; Omland, Øyvind (Peer reviewed; Journal article, 2022)
      Objectives: To examine the risk of cancer in former school children exposed to environmental asbestos in childhood with a focus on female cancers, including breast cancer. Methods: We retrieved a cohort of females (n = ...

    • COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study 

      Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Karen, Rosendahl; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei (Peer reviewed; Journal article, 2023)
      Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ...

    • Cold agglutinin disease revisited: a multinational, observational study of 232 patients 

      Berentsen, Sigbjørn; Barcellini, Wilma; D'Sa, Shirley; Randen, Ulla; Tvedt, Tor Henrik Anderson; Fattizzo, Bruno; Haukås, Einar; Kell, Megan; Brudevold, Robert; Dahm, Anders Erik Astrup; Dalgaard, Jakob; Frøen, Hege; Hallstensen, Randi; Jæger, Pernille Horgmo; Hjorth-Hansen, Henrik; Malecka, Agnieszka Maria; Oksman, Markku; Rolke, Jürgen; Sekhar, Mallika; Sørbø, Jon Hjalmar; Tjønnfjord, Eirik; Tsykunova, Galina; Tjønnfjord, Geir Erland (Peer reviewed; Journal article, 2020)
      We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in 5 countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we ...

    • Colonic mucosal gene expression in inflammatory bowel disease: From whole genome to REG gene family expression 

      Granlund, Atle van Beelen (Doktoravhandlinger ved NTNU, 1503-8181; 2013:111, Doctoral thesis, 2013)
      Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the digestive tract. The two main forms of IBD are ulcerative colitis (UC) and Crohn’s disease (CD). As IBD are chronic diseases, often with ...

    • Colorectal cancer patients’ experiences with supervised exercise during adjuvant chemotherapy—A qualitative study 

      Hatlevoll, Ingunn; Skolbekken, John-Arne; Oldervoll, Line Merethe; Wibe, Arne; Hofsli, Eva (Peer reviewed; Journal article, 2021)
      Background Colorectal cancer (CRC) is a common cancer worldwide, with increasing numbers surviving and living with long-term side effects from treatment. Physical exercise during or after treatment may have several beneficial ...

    • Colorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial 

      Randel, Kristin Ranheim; Schult, Anna Lisa; Botteri, Edoardo; Hoff, Geir; Bretthauer, Michael; Ursin, Giske; Natvig, Erik; Berstad, Paula; Jørgensen, Anita; Sandvei, Per Kristian; Olsen, Marie Kristin Ek; Frigstad, Svein Oskar; Darre-Næss, Ole; Norvard, Espen R.; Bolstad, Nils; Kørner, Hartwig; Wibe, Arne; Wensaas, Knut-Arne; de Lange, Thomas; Holme, Øyvind (Peer reviewed; Journal article, 2020)
      Background and aims: The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. Methods: Individuals aged 50-74 years living in South-East Norway ...

    • Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response 

      Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi; Crombag, Marie-Rose B.S.; Peppelenbosch, Maikel P.; Kaynov, Denis; Pan, Qiuwei (Peer reviewed; Journal article, 2023)
      Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ...

    • Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2 

      Wagoner, Jessica; Herring, Shawn; Hsiang, Tien-Ying; Ianevski, Aleksandr; Biering, Scott B.; Xu, Shuang; Hoffmann, Markus; Pöhlmann, Stefan; Gale, Michael; Aittokallio, Tero Antero; Schiffer, Joshua T.; White, Judith M.; Polyaka, Stephen J. (Peer reviewed; Journal article, 2022)
      Three directly acting antivirals (DAAs) demonstrated substantial reduction in COVID-19 hospitalizations and deaths in clinical trials. However, these agents did not completely prevent severe illness and are associated with ...

    • Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ...

    • Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses 

      Islam, Rakibul; Islam, Mohammad Mirazul; Nilsson, Per H.; Mohlin, Camilla; Hagen, Kjersti Thorvaldsen; Paschalis, Eleftherios I.; Woods, Russell L.; Bhowmick, Sabuj Chandra; Dohlman, Claes H.; Espevik, Terje; Chodosh, James; Gonzalez-Andrades, Miguel; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2021)
      Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism of xenograft rejection. We hypothesized ...

    • Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome 

      Thomas, Anub Mathew; Schjalm, Camilla; Nilsson, Per; Lindenskov, Paal Helge H.; Rørtveit, Runa; Solberg, Rønnaug; Saugstad, Ola Didrik; Berglund, Magnus M.; Strömberg, Patrik; Lau, Corinna; Espevik, Terje; Jansen, Johan Høgset; Castellheim, Albert; Mollnes, Tom Eirik; Barratt-Due, Andreas (Journal article; Peer reviewed, 2018)
      Background: Meconium aspiration syndrome (MAS) is a severe lung condition affecting newborns and it can lead to a systemic inflammatory response. We previously documented complement activation and cytokine release in a ...

    • Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis 

      Hellerud, Bernt C; Orrem, Hilde L.; Dybwik, Knut Gustav; Pischke, Søren Erik; Barratt-Due, Andreas; Castellheim, Albert; Fure, Hilde; Bergseth, Grete; Christiansen, Dorte; Nunn, Miles A.; Espevik, Terje; Lau, Corinna; Brandtzæg, Petter; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2017)
      Background Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key ...

    • Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing the toll-like receptor 4-MD2 complex 

      Gustavsen, Alice; Nymo, Stig Haugset; Landsem, Anne; Christiansen, Dorte; Ryan, Liv; Husebye, Harald; Lau, Corinna; Pischke, Søren Erik; Lambris, John D.; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2016)
      Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including TLR4 and TLR2. The aim of this study was to investigate the effect ...

    • Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis 

      Skjeflo, Espen Waage; Sagatun, Caroline; Dybwik, Knut; Aam, Sturla; Urving, Sven Haakon; Nunn, Miles A.; Fure, Hilde; Lau, Corinna; Brekke, Ole Lars; Huber-Lang, Markus; Espevik, Terje; Barratt-Due, Andreas; Nielsen, Erik Waage; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2015)
      Introduction Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of innate immunity recognition systems including complement and the Toll-like receptor family initiate this disproportionate ...

    • Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase 

      Roberts, Victoria A.; Pique, Michael E.; Hsu, Simon; Li, Sheng; Slupphaug, Geir; Rambo, Robert P.; Jamison, Jonathan P.; Liu, Tong; Lee, Jun H.; Tainer, John A.; Ten Eyck, Lynn F.; Woods Jr., Virgil L. (Journal article; Peer reviewed, 2012)
      X-ray crystallography provides excellent structural data on protein–DNA interfaces, but crystallographic complexes typically contain only small fragments of large DNA molecules. We present a new approach that can use longer ...

    • Combining optimal nutrition and exercise in a multimodal approach for patients with active cancer and risk for losing weight: Rationale and practical approach 

      Solheim, Tora Skeidsvoll; Vagnildhaug, Ola Magne; Laird, Barry J; Balstad, Trude Rakel (Journal article; Peer reviewed, 2019)
      Weight loss and functional decline is a common and detrimental consequence of cancer. The interventions that are offered to patients with weight loss and functional decline often seem haphazard and varying from center to ...