Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 3283-3302 of 3434
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"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling
(Journal article; Peer reviewed, 2018)Low response rate and rapid development of resistance against commonly used chemotherapeutic regimes demand new multi-targeting anti-cancer strategies. In this study, we target the stress-related roles of the scaffold ... -
Two-year motor outcomes associated with the dose of NICU based physical therapy: The Noppi RCT
(Peer reviewed; Journal article, 2022)Background Interventions involving both the parent and the preterm infant have demonstrated lasting effects on cognitive outcomes, but motor effects are less salient. It remains unclear when to commence early intervention ... -
TXNL1-XRCC1 pathway regulates cisplatin-induced cell death and contributes to resistance in human gastric cancer
(Journal article; Peer reviewed, 2014)Cisplatin is a cytotoxic platinum compound that triggers DNA crosslinking induced cell death, and is one of the reference drugs used in the treatment of several types of human cancers including gastric cancer. However, ... -
Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
(Journal article; Peer reviewed, 2023) -
Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
(Journal article; Peer reviewed, 2016)The innate immune system is the first line of defense against Neisseria gonorrhoeae (GC). Exposure of cells to GC lipooligosaccharides induces a strong immune response, leading to type I interferon (IFN) production via ... -
Types of Gastric Carcinomas
(Journal article; Peer reviewed, 2018)Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are typically localized to one of the three mucosae; ... -
Typical and Atypical Presentations of Gastroesophageal Reflux Disease Diagnostic and Therapeutic Challenges
(Doctoral thesis at NTNU;2015:79, Doctoral thesis, 2015) -
Tyrosine Kinase Inhibitors Target B Lymphocytes
(Peer reviewed; Journal article, 2023)Autoimmune disorders and some types of blood cancer originate when B lymphocytes malfunction. In particular, when B cells produce antibodies recognizing the body’s proteins, it leads to various autoimmune disorders. ... -
UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines
(Journal article; Peer reviewed, 2021)Metabolic rewiring is one of the indispensable drivers of epithelial-mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
(Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ... -
Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential
(Journal article; Peer reviewed, 2019)Using a lepirudin-based human whole blood model, we evaluated the initial inflammatory and coagulation responses of dense and porous ultrapure (<50 endotoxin units/grams) cellulose nanofibrils (CNF), of carboxylated grade. ... -
Ultrasound &prediction of prolonged labor
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:242, Doctoral thesis, 2013) -
Ultrasound and microbubble-enhanced therapy of Gastrointestinal tumors using conventional cytotoxic drugs in preclinical and clinical settings
(Doctoral theses at NTNU;2024:94, Doctoral thesis, 2024)Pancreatic ducal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a very short life expectancy. Together with late diagnosis and aggressive biology, chemoresistance is one important cause of poor survival. ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
(Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ... -
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
(Journal article; Peer reviewed, 2017)Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ... -
UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
(Peer reviewed; Journal article, 2021)Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of ... -
Understanding and preventing Mycobacterium avium infections
(Doctoral theses at NTNU;2018:178, Doctoral thesis, 2018)Mycobacterium avium (Mav) complex (MAC) is a group of slow growing, environmental opportunist pathogens, that have been associated with animal and human infections. Mav is one of the species belonging to MAC, which can be ... -
Understanding cellular responses induced by gastrin in gastric adenocarcinoma cells
(Doctoral thesis at NTNU;2015:316, Doctoral thesis, 2015)Sammendrag: Hormonet gastrin spiller en sentral rolle i regulering av magesyre og i utvikling og vedlikehold av normal mageslimhinne. Gastrin har i tillegg en generell vekstfremmende effekt både på normale celler og på ... -
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
(Journal article; Peer reviewed, 2011)Cytotoxicity of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FdUrd) due to DNA fragmentation during DNA repair has been proposed as an alternative to effects from thymidylate synthase (TS) inhibition or RNA incorporation. ... -
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
(Journal article; Peer reviewed, 2019)The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is ...