Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 3059-3078 of 3438
-
Testing the flexibility of mitochondrial functioning in insulin-producing β-cells under diabetes like conditions in vitro
(Master thesis, 2019)Bakgrunn: Kronisk hyperglykemi er skadelig for de insulinproduserende β-cellene i pankreas. Mitokondrienes funksjon i disse cellene er helt essensiell for at β-cellene skal fungere optimalt. Mitokondriene påvirkes trolig ... -
Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells - gene expression profiling implies endoplasmic reticulum stress
(Journal article; Peer reviewed, 2011)Background Previous reports have shown an antiproliferative effect of the synthetic, 3-thia fatty acid tetradecylthioacetic acid (TTA) on different cancer cells in vitro and in vivo. The mechanisms behind the observed ... -
TFCheckpoint database update, a cross-referencing system for transcription factors from human, mouse and rat
(Journal article; Peer reviewed, 2023)Prior knowledge about DNA-binding transcription factors (dbTFs), transcription co-regulators (coTFs) and general transcriptional factors (GTFs) is crucial for the study and understanding of the regulation of transcription. ... -
TGF-β contamination of purified recombinant GDF15
(Journal article; Peer reviewed, 2017)Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in mammalian expression systems, such as CHO-cells or HEK293-cells. ... -
The alternative complement pathway is dysregulated in patients with chronic heart failure
(Journal article; Peer reviewed, 2017)The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; ... -
The anti-apoptotic protein survivin can improve the prognostication of meningioma patients
(Journal article; Peer reviewed, 2017)Background The 2016 WHO histopathological grading includes a substantial within-variation in recurrence risk, and is thus insufficient to predict prognosis after initial surgery of patients suffering from meningiomas. ... -
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia
(Journal article; Peer reviewed, 2016)Objective: Preeclampsia is a complex heterogeneous disease commonly defined by newonset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later ... -
The APIM-peptide, a novel anti-cancer drug targeting the stress-related roles of PCNA
(Doctoral theses at NTNU;2019:186, Doctoral thesis, 2019) -
The applicability of a weight loss grading system in cancer cachexia: a longitudinal analysis
(Journal article; Peer reviewed, 2017)Background A body mass index (BMI) adjusted weight loss grading system (WLGS) is related to survival in patients with cancer. The aim of this study was to examine the applicability of the WLGS by confirming its prognostic ... -
The Artificial Pancreas: A Dynamic Challenge
(Journal article; Peer reviewed, 2016)In patients with diabetes mellitus type 1, the pancreatic insulin production ceases, causing raise in blood glucose level (BGL) and potentially severe long-term complications. The “holy grail” of diabetes treatment is the ... -
The association between the clinical diversity of psoriasis and depressive symptoms: the HUNT Study, Norway
(Journal article; Peer reviewed, 2017)Background While a number of observational hospital‐based studies have reported an association between psoriasis and depression, less is known about the clinical diversity of psoriasis and depressive symptoms. Objective To ... -
The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and negative subjects: A post-hoc analysis of the ORIGIN trial
(Journal article; Peer reviewed, 2018)We compared cardiovascular and other outcomes in patients with dysglycaemia with or without anti‐glutamic acid dehydrogenase (GAD) antibodies participating in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) ... -
The Association of Tissue Steroid Hormone Levels with Body Mass Index and Endocrine Treatment Resistance in Women with Estrogen Receptor-positive Breast Cancer
(Master thesis, 2022)Abstract will be available on 2023-07-01 -
The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway
(Journal article; Peer reviewed, 2018)Background Sedentary behavior is thought to pose different risks to those attributable to physical inactivity. However, few studies have examined the association between physical activity and sitting time with cancer ... -
The biological importance of gastrin-induced genes, NR4A2 and SIK1
(Master thesis, 2011) -
The Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Norwegian Children
(Journal article; Peer reviewed, 2017)Background. The burden of severe human metapneumovirus (HMPV) respiratory tract infections (RTIs) in European children has not been clarified. We assessed HMPV in Norwegian children and compared hospitalization rates for ... -
The C-terminus of AID masks the N-terminal bipartite NLS and prevents nuclear import
(Master thesis, 2009) -
The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study
(Journal article; Peer reviewed, 2013)Cigarette smoking is strongly associated with mental illness but the causal direction of the association is uncertain. We investigated the causal relationship between smoking and symptoms of anxiety and depression in the ... -
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
(Journal article; Peer reviewed, 2017)Objective Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be ... -
The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: Recommendations from the European Myeloma Network
(Journal article; Peer reviewed, 2014)Monoclonal gammopathy of undetermined significance is one of the most common pre-malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are precursor conditions of multiple myeloma; light-chain ...