Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 1926-1945 of 3434

    • Maintenance pemetrexed therapy in advanced non-smallcell lung cancer 

      Stokke, Kristin (Doctoral theses at NTNU;2023:312, Doctoral thesis, 2023)
      Lung cancer is the most common cancer world-wide, the third most common in Norway after colonand breast cancer, but the most common cause of cancer-related deaths both globally and nationally (1, 2). In 2021, 3499 new cases ...

    • Major durable response of pembrolizumab in chemotherapy refractory small cell bladder cancer: A case report 

      Nguyen, Olav Toai Duc; Sundstrøm, Stein Harald; Westvik, Ganna Surzhykova; Røttereng, Ane Karoline Stræte; Melhus, Mona Røli; Bergseth, Cecilie; Hallem, Elisabeth Kvelstad; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2020)
      Small cell carcinoma of the urinary bladder is a rare subtype (incidence of 1–9/1,000,000), characterized by an aggressive behavior with early metastasis and poor prognosis. Chemotherapy, radiation, and surgery are the ...

    • Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication 

      Konstantinidis, Ioannis; Sætrom, Pål; Mjelle, Robin; Nedoluzhko, Artem; Robledo, Diego; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2020)
      The historically recent domestication of fishes has been essential to meet the protein demands ofa growing human population. Selection for traits of interest during domestication is a complexprocess whose epigenetic basis ...

    • Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach 

      Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)
      Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ...

    • Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach 

      Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)
      Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ...

    • Malignant pleural mesothelioma: History, controversy and future of a manmade epidemic 

      Røe, Oluf Dimitri; Stella, Giulia Maria (Journal article; Peer reviewed, 2015)
      Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, ...

    • Malnutrition, nutritional interventions and clinical outcomes of patients with acute small bowel obstruction: results from a national, multicentre, prospective audit 

      NASBO, NASBO Collaborators; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2019)
      Objective The aim of this study was to assess the nutritional status of patients presenting with small bowel obstruction (SBO), along with associated nutritional interventions and clinical outcomes. Design Prospective ...

    • The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues 

      Pandey, Radha Raman; Delfino, Elena; Homolka, David; Roithova, Adriana; Chen, Kuan-Ming; Li, Lingyun; Franco, Giulia; Vågbø, Cathrine Broberg; Taillebourg, Emmanuel; Fauvarque, Marie-Odile; Pillai, Ramesh S. (Peer reviewed; Journal article, 2020)
      The 5′ end of eukaryotic mRNAs is protected by the m7G-cap structure. The transcription start site nucleotide is ribose methylated (Nm) in many eukaryotes, whereas an adenosine at this position is further methylated at the ...

    • Management of a life-threatening intercostal artery bleeding, difficult to visualize in open surgery: a case report 

      Laugsand, Eivor Alette; Xanthoulis, Athanasios (Peer reviewed; Journal article, 2020)
      Life-threatening bleeding from an intercostal artery is a rare and challenging event. A 74-year-old patient with a right-sided pleural effusion was treated by a pigtail pleural drain. He developed a large haemothorax, ...

    • Manglende etterlevelse - også en bevisst handling 

      Bell, Hege Therese; Sletvold, Hege; Reppe, Linda Amundstuen (Journal article; Peer reviewed, 2016)
      Alle pasienter har ulike oppfatninger av sykdom og legemidler. Pasienter veier gjerne nytten av legemiddelbehandlingen mot ulemp¬ene, og dette kommuniseres ikke alltid med helsepersonell. Tro på egen mestring av legemiddelregimet ...

    • Mannose-Binding Lectin Deficiency Is Associated with Myocardial Infarction: The HUNT2 Study in Norway 

      Vengen, Inga Thorsen; Madsen, Hans O; Garred, Peter; Platou, Carl Geoffrey Parrinder; Vatten, Lars Johan; Videm, Vibeke (Journal article; Peer reviewed, 2012)
      Objectives: Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) ...

    • The many functions of ESCRTs 

      Vietri, Marina; Radulovic, Maja; Stenmark, Harald (Peer reviewed; Journal article, 2019)
      Cellular membranes can form two principally different involutions, which either exclude or contain cytosol. The ‘classical’ budding reactions, such as those occurring during endocytosis or formation of exocytic vesicles, ...

    • Mapping nanoparticles in hydrogels: A comparison of preparation methods for electron microscopy 

      Muri, Harald Ian; Hoang, Linh; Hjelme, Dag Roar (Journal article; Peer reviewed, 2018)
      The distribution of noble metal nanoparticles (NMNPs) in hydrogels influences their nanoplasmonic response and signals used for biosensor purposes. By controlling the particle distribution in NMNP-nanocomposite hydrogels, ...

    • Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions 

      Olsen, Maria Belland; Sannes, Ann-Christin; Yang, Kuan; Nielsen, Morten Birkeland; Einarsen, Ståle Valvatne; Christensen, Jan Olav; Pallesen, Ståle; Bjørås, Magnar; Gjerstad, Johannes (Peer reviewed; Journal article, 2022)
      Environmental stressors such as repeated social defeat may initiate powerful activation of subconscious parts of the brain. Here, we examine the consequences of such stress (induced by resident-intruder paradigm) on the ...

    • Mapping post - translational histone modifications and the TH2B variant in spermatogenesis 

      Holmsen, Camilla (Master thesis, 2012)
      Epigenetics has been defined by Goldberg et al. [1] as the study of heritable changes in gene expression or cellular phenotype which arises without changes in the DNA sequence. Post-translational histone modification and ...

    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...

    • Marine bioaktive fiskepeptider for forebygging av overvekt og mikrobiotarelaterte sykdommer i mennesker og dyr 

      Berge, Rolf Kristian; Bjørndal, Bodil; Aas, Grete Hansen; Dankel, Simon N; Remme, Jannicke; Sterten, Hallgeir; Ahlstrøm, Øystein; Hov, Johannes Espolin Roksund; Røsvik, Anne Synnøve; Hoff, Dag Arne Lihaug (Research report, 2022)

    • Markers of autoimmunity in Latent Autoimmune Diabetes in Adults (LADA) and non-diabetic adults: Impact in phenotype and genetic predisposition: Results from the Nord-Trøndelag health study 

      Sørgjerd, Elin Pettersen (Doktoravhandlinger ved NTNU, 1503-8181; 2013:113, Doctoral thesis, 2013)
      Diabetes is mainly classified: type 1 and type 2 diabetes. Type 1 diabetes is an autoimmune disease in which the body's immune system attacks and destroys the beta cells that produce insulin. Patients with type 2 diabetes ...

    • Markers of endothelial glycocalyx dysfunction in Clarkson disease 

      Xie, Zhihui; Børset, Magne; Sveen, Kjell; Bøe, Ole Wilhelm; Chan, Eunice C.; Lack, Justin B.; Hornick, Katherine M.; Verlicchi, Franco; Eisch, A. Robin; Melchio, Remo; Dudek, Arkadiusz Z.; Druey, Kirk M. (Peer reviewed; Journal article, 2022)
      Background Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition marked by transient, relapsing-remitting episodes of systemic microvascular ...

    • Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD 

      Bullen, Alexander L.; Ascher, Simon B.; Scherzer, Rebecca; Garimella, Pranav S.; Katz, Ronit; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Malhotra, Rakesh; Seegmiller, Jesse C.; Shlipak, Michael G.; Ix, Joachim H. (Peer reviewed; Journal article, 2022)
      Significance Statement SPRINT demonstrated in individuals with hypertension and high cardiovascular disease (CVD) risk that intensive BP lowering was associated with decreased risk of CVD events and all-cause mortality. ...