Browsing Institutt for klinisk og molekylær medisin by Title
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Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms
(Peer reviewed; Journal article, 2023)The chloroplast signal recognition particle (CpSRP) receptor (CpFTSY) is a component of the CpSRP pathway that post-translationally targets light-harvesting complex proteins (LHCPs) to the thylakoid membranes in plants and ... -
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
(Peer reviewed; Journal article, 2021)Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ... -
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
(Peer reviewed; Journal article, 2020)Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, ... -
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
(Peer reviewed; Journal article, 2023)Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ... -
Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study
(Journal article; Peer reviewed, 2021)Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ... -
Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer
(Journal article; Peer reviewed, 2012)Introduction Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNA-damaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 ... -
Low fat, low lactose diet used as prophylactic treatment of acute intestinal reactions during pelvic radiotherapy. A prospective randomised study
(Dissertations at the Faculty of Medicine, 0805-7680; 203, Doctoral thesis, 2002)Purpose. The main aim of the present study was to evaluate the effect of a low fat, low lactose diet on acute and late gastrointestinal side effects of pelvic radiotherapy. We also wanted to evaluate if such a treatment ... -
Low frequency cerebral arterial and venous flow oscillations in healthy neonates measured by NeoDoppler
(Peer reviewed; Journal article, 2022)Background: A cerebroprotective effect of low frequency oscillations (LFO) in cerebral blood flow (CBF) has been suggested in adults, but its significance in neonates is not known. This observational study evaluates normal ... -
Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients
(Journal article; Peer reviewed, 2016)Background Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement ... -
Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia
(Journal article; Peer reviewed, 2018)Background Disease severity and outcome in community-acquired pneumonia (CAP) depend on the host and on the challenge of the causal microorganism(s). We measured levels of immunoglobulins (Igs) and complement in 257 ... -
Low serum lipocalin-2 in pregnant women with systemic lupus erythematosus
(Peer reviewed; Journal article, 2023)OBJECTIVES: Systemic lupus erythematosus (SLE) pregnancies are considered high-risk due to risk of disease flare and pregnancy complications. A more in-depth understanding of the immunological alterations in SLE patients ... -
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
(Journal article; Peer reviewed, 2019)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ... -
Low-contrast detectability and potential for radiation dose reduction using deep learning image reconstruction-A 20-reader study on a semi-anthropomorphic liver phantom
(Peer reviewed; Journal article, 2022)Background A novel deep learning image reconstruction (DLIR) algorithm for CT has recently been clinically approved. Purpose To assess low-contrast detectability and dose reduction potential for CT images reconstructed ... -
Low-contrast detectability and potential for radiation dose reduction using deep learning image reconstruction—A 20-reader study on a semi-anthropomorphic liver phantom
(Peer reviewed; Journal article, 2022)Background A novel deep learning image reconstruction (DLIR) algorithm for CT has recently been clinically approved. Purpose To assess low-contrast detectability and dose reduction potential for CT images reconstructed ... -
Low-grade albuminuria and its implementation in cardiovascular risk assessment: Analyses from the Nord-Trøndelag Heath Studies; HUNT-2 and HUNT-3
(Doctoral theses at NTNU;2017:338, Doctoral thesis, 2017) -
LRRK2 to the rescue of damaged endomembranes
(Peer reviewed; Journal article, 2020)Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine-rich repeat kinase 2 (LRRK2) is activated in response to ... -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
(Journal article; Peer reviewed, 2020)Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ... -
Lung function in adults born preterm
(Journal article; Peer reviewed, 2018)Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function ... -
Lynch syndrome mutation spectrum in New South Wales, Australia, including 55 novel mutations
(Peer reviewed; Journal article, 2016)Background Lynch syndrome, the most frequent hereditary colorectal cancer syndrome, is caused by defects in mismatch repair genes. Genetic testing is important in order to identify mutation carriers who can benefit from ... -
LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes
(Journal article; Peer reviewed, 2011)Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation. A key component of LDL is lysophosphatidylcholine ...