Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1116-1135 of 3444
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Experimental-Computational Approaches to Identify Synergistic Effects of Anti-Cancer Drugs
(Doctoral theses at NTNU;2019:384, Doctoral thesis, 2019)Drug combinations are hoped to improve treatment response to anti-cancer drugs by targeting the cancers vulnerabilities at diverse trajectories. With a large number of approved agents of chemotherapeutic and targeted ... -
Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data.
(Journal article; Peer reviewed, 2019)Maximal expiratory airflow peaks early in the third decade of life, then gradually declines with age. The pattern of airflow through adulthood for individuals born very preterm (at <32 weeks’ gestation) or ... -
Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
(Peer reviewed; Journal article, 2022)Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using ... -
Explaining variation in cancer survival between 11 jurisdictions in the International Cancer Benchmarking Partnership: a primary care vignette survey
(Peer reviewed; Journal article, 2015)Objectives The International Cancer Benchmarking Partnership (ICBP) is a collaboration between 6 countries and 12 jurisdictions with similar primary care-led health services. This study investigates primary care physician ... -
Exploration of 27 plasma immune markers: A cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons
(Journal article; Peer reviewed, 2018)Background The prevalence of major depression (MD) according to population studies is the same for old (65 years and older) and younger adults. In contrast, an elevated proportion of old MD patients are hospitalized ... -
Exploring autophagy and its components in relation to the of the innate immune system
(Master thesis, 2009) -
Exploring Biomarkers for Weight Loss in Cancer Cachexia: The Prognostic Value of Serum sP-selectin, Activin A and Autophagy-stimulatory Activity
(Master thesis, 2012)Cancer cachexia is an extremely devastating wasting syndrome that adversely influences treatment response, quality of life and survival rates of patients. It involves severe metabolic imbalance resulting in progressive ... -
Exploring Dietary Intake in Adults with Severe Obesity and Associations with the FTO rs9939609 Genotypes
(Peer reviewed; Journal article, 2023)Background Few have studied the associations between rs9939609 genotypes in the obesity candidate locus FTO and energy and nutrient intakes and meal frequencies in adults with severe obesity. We are unaware of studies ... -
Exploring drug resistance mechanisms in Multiple Myeloma - Focusing on the role of immunoglobulin kappa light chain and protein secretion
(Master thesis, 2019)Multiple myeloma (MM) is a type of cancer arising in the bone marrow affecting the immunoglobulin (Ig) producing plasma cells. This causes an uncontrolled proliferation of a single plasma cell clone and an overproduction ... -
Exploring lifestyle and risk in preventing type 2 diabetes-a nested qualitative study of older participants in a lifestyle intervention program (VEND-RISK)
(Journal article; Peer reviewed, 2016)Background: Lifestyle intervention may reduce the development of type 2 diabetes among high-risk individuals. The aim of this study was to explore how older adults perceived their own lifestyle and being at increased ... -
Exploring responses of type I and type III interferons in human macrophages
(Master thesis, 2021)Interferons are antiviral cytokines induced during viral infection. Type I and III IFNs are thought to share some of the same transcriptional outputs, yet some biological responses are distinct. IFN-λ receptor (IFNLR1) ... -
Exploring the Crosstalk Between RIG-I-mediated Signalling and β-catenin
(Master thesis, 2011)Hepatocellular carcinoma (HCC) is the most common type of liver cancer and among the leading causes of cancer related death worldwide. Hepatocarcinogenesis has been attributed to chronic viral infection and alterations in ... -
Exploring the diagnostic potential of adding T2 dependence in diffusion-weighted MR imaging of the prostate
(Peer reviewed; Journal article, 2021)Background: Magnetic resonance imaging (MRI) is essential in the detection and staging of prostate cancer. However, improved tools to distinguish between low-risk and high-risk cancer are needed in order to select the ... -
Exploring the fungal microbiome in breast cancer patients
(Master thesis, 2021)The role of the Fungal Microbiome in the human body has been gradually revealed. Its presence in the gut, although scarce in comparison to bacteria, is now associated with several physiologic functions such as immune ... -
Exploring the hepatitis C virus encoded protease NS3/4A in relation to Autophagy
(Master thesis, 2011)Autophagy is an evolutionarily conserved intracellular bulk degradation system essential for the cell homeostasis. In addition, autophagy is emerging as a central component in viral host defense. Many pathogens have evolved ... -
Exploring the relationship between bone density and severity of distal radius fragility fracture in women
(Journal article; Peer reviewed, 2014)Background Bone mineral density (BMD) has been shown to be a consistent and independent risk factor for distal radius fracture. Inconsistent data have been reported on the association between BMD and severity of distal ... -
Exploring the role of IKKε during hepatitis C virus infection with focus on lipid accumulation
(Master thesis, 2020)Hepatitis C virus (HCV) targets the hepatocytes in the liver. HCV develops a chronic infection in 85% of infected patients which develops over decades and have different outcomes, for example hepatic steatosis (accumulation ... -
Exploring the role of the immunoglobulin-like receptor SLAMF1 in infection with human metapneumovirus
(Master thesis, 2021)Humant metapneumovirus (HMPV) er en ledende årsak til nedre luftveisinfeksjon. Generelt finnes det lite informasjon om hvordan HMPV entrer (infiserer), etablerer replikasjon og induserer immunresponser. Nylige funn fra en ... -
Exploring the role of TLR8 as a sensor in bacterial infections
(Doctoral theses at NTNU;2019:382, Doctoral thesis, 2019) -
Exploring the viability of measuring zinc and prostate-specific antigen in urine as a diagnostic tool for prostate cancer
(Master thesis, 2021)Bakgrunn: Nåværende metoder for å diagnostisere prostatakreft benytter seg av inngripende biopsier, som kan føre til komplikasjoner som infeksjon og død. Ikke-inngripende metoder benytter seg av PSA målinger, som ofte er ...