Now showing items 1156-1175 of 1899

    • N-3 Polyunsaturated Fatty Acids in Health and Disease - Clinical and Molecular Aspects 

      Slagsvold, Jens Erik (Doktoravhandlinger ved NTNU, 1503-8181; 2009:119, Doctoral thesis, 2009)
        Omega-3 Flerumettede Fettsyrer og Helse – Kliniske og Molekylære Aspekter Omega-3 fettsyrer tilhører gruppen essensielle fettsyrer. Det betyr at vi ikke kan lage dem selv, men at de må tilføres gjennom kosten, ...
    • N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2 

      Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)
      Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ...
    • Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach 

      Malmo, Jostein; Sandvig, Axel; Vårum, Kjell Morten; Strand, Sabina P. (Journal article; Peer reviewed, 2013)
      Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ...
    • Nanoplastics - A Potential Threat To Human Health? 

      Solhaug, Helene (Master thesis, 2019)
      Den økende bruken av nanomaterialer i alt fra forbruksprodukter til medisiner har ført til en økende offentlig interesse for hvilke følger eksponeringen kan ha for mennesker og helse. Det å forstå hvilke inflammatoriske ...
    • National prospective cohort study of the burden of acute small bowel obstruction 

      NASBO, NASBO Collaborators; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2019)
      Background Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed ...
    • Naturally occurring phenethyl isothiocyanate-induced inhibition of gastric cancer cell growth by disruption of microtubules 

      Øverby, Anders; Zhao, Chun-Mei; Bones, Atle M.; Chen, Duan (Journal article; Peer reviewed, 2014)
      Abstract Background and Aim Phenethyl isothiocyanate (PEITC) derives from vegetables commonly consumed by man and has been demonstrated as a promising chemopreventive agent against several types of cancer. However, the ...
    •  Ultrasound and labour 

      Eggebø, Torbjørn Moe (Doktoravhandlinger ved NTNU, 1503-8181; 2009:77, Doctoral thesis, 2009)
      2.1 Innledning  Alle kvinner ønsker seg en ukomplisert fødsel, men komplikasjoner kan oppstå plutselig og uventet. I følge Verdens Helseorganisasjon trenger 15% av de gravide kyndig hjelp under svangerskap eller ...
    • Nedregulering av urokinase ved hjelp av RNA-interferens 

      Hammervold, Kristen Kåre Rembar (Master thesis, 2009)
    • Neil3 induced neurogenesis protects against prion disease during the clinical phase 

      Jalland, Clara Maria Osnes; Scheffler, Katja; Benestad, Sylvie Lafond; Moldal, Torfinn; Ersdal, Cecilie; Gunnes, Gjermund; Suganthan, Rajikala; Bjørås, Magnar; Tranulis, Michael A. (Journal article; Peer reviewed, 2016)
      Base excision repair (BER) is the major pathway for repair of oxidative DNA damage. Mice with genetic knockout of the BER enzyme Neil3 display compromised neurogenesis in the sub-ventricular zone of the lateral ventricle ...
    • Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice 

      Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål (Peer reviewed; Journal article, 2016)
      Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ...
    • NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture 

      Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra (Journal article; Peer reviewed, 2017)
      Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a ...
    • Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial 

      Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne; Mortensen, Kim Erlend; Smaaland, Rune; Sorbye, Halfdan; Verbeke, Caroline Sophie; Dueland, Svein (Journal article; Peer reviewed, 2017)
      Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ...
    • NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates. 

      Vik, Sigrid Dannheim; Torp, Hans; Follestad, Turid; Støen, Ragnhild; Nyrnes, Siri Ann (Journal article; Peer reviewed, 2019)
      BACKGROUND: There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. ...
    • Neonatal biomarkers and morbidity as risk factors for visual impairment in extremely low gestational age newborns 

      Holm, Mari (Doctoral theses at NTNU;2017:183, Doctoral thesis, 2017)
      Being born preterm imposes a risk of increased mortality and numerous morbidities on the infant. Preterm newborns carry their "birth history" with them throughout life; this implies an increased risk of problems related ...
    • Nephronectin in breast cancer progression and metastasis 

      Toraskar, Jimita Prashant (Doctoral theses at NTNU;2018:390, Doctoral thesis, 2018)
      Breast cancer is life threatening due to its ability to spread and invade other tissues. The best approach in solving a problem of this sort is to be able to reason backwards. Tumors appear chaotic as they are composed of ...
    • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

      Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2018)
      Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in ...
    • Neural correlates of working memory training in HIV patients: Study protocol for a randomized controlled trial 

      Chang, Linda; Løhaugen, Gro; Douet, Vanessa; Miller, Eric N.; Skranes, Jon Sverre; Ernst, Thomas (Peer reviewed; Journal article, 2016)
      Background Potent combined antiretroviral therapy decreased the incidence and severity of HIV-associated neurocognitive disorders (HAND); however, no specific effective pharmacotherapy exists for HAND. Patients with HIV ...
    • Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. 

      Dubeykovskaya, Z; Si, Y; Chen, X; Worthley, DL; Renz, BW; Urbanska, AM; Hayakawa, Y; Xu, T; Westphalen, CB; Dubeykovskiy, A; Chen, Duan; Friedman, RA; Asfaha, S; Nagar, S; Tailor, Y; Muthupalani, S; Fox, JG; Kitajewski, J; Wang, Timothy C. (Peer reviewed; Journal article, 2016)
      CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and ...
    • Neurodevelopmental origins of lifespan changes in brain and cognition 

      Walhovd, Kristine B; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Bartsch, Hauke; Bjørnerud, Atle; Due-Tønnessen, Paulina; Grydeland, Håkon; Hagler, D.; Håberg, Asta; Kremen, William S.; Ferschmann, Lia; Nyberg, Lars; Panizzon, Matthew S; Rohani, Darius; Skranes, Jon Sverre; Storsve, Andreas Berg; Sølsnes, Anne Elisabeth; Tamnes, Christian Krog; Thompson, Wesley K.; Reuter, Chase; Dale, Anders; Fjell, Anders Martin (Journal article; Peer reviewed, 2016)
      Neurodevelopmental origins of functional variation in older age are increasingly being acknowledged, but identification of how early factors impact human brain and cognition throughout life has remained challenging. Much ...
    • Neuroendocrine Aspects of Physiology and Disease 

      Hauso, Øyvind (Doktoravhandlinger ved NTNU, 1503-8181; 2009:93, Doctoral thesis, 2009)
      De nevroendokrine celler står i en mellomstilling mellom nerveceller (nevro-) og hormonproduserende celler (-endokrine). Disse finnes i et helt spekter, spredt i overflaten av kroppens fleste organer. To viktige nevroendokrine ...