Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 704-723 av 3430
-
Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells
(Journal article; Peer reviewed, 2019)Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ... -
Cytosolic scaffold functions of PCNA
(Doctoral theses at NTNU;2017:203, Doctoral thesis, 2017)PCNA som et plattform-protein i cytosol Kroppen vår består av millioner av celler som alle stammer fra en enkelt celle. For hver celledeling må arvestoffet, DNA-et, kopieres feilfritt i et samarbeid mellom mange ulike ... -
Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™
(Journal article; Peer reviewed, 2017)Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, ... -
Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid
(Journal article; Peer reviewed, 2019)Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is ... -
Cytotoxicity and repair of uracil and 5-fluorouracil in DNA
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:95, Doctoral thesis, 2011)Cytotoksisitet og reparasjon av uracil og 5-fluorouracil i DNA Vårt arvemateriale (gener) er organisert i 23 kromosompar, som det finnes fullstendige kopier av i storparten av våre celler. Hvert kromosom består av en lang ... -
Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles
(Journal article; Peer reviewed, 2017)Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ... -
Dansk embryologikompendium
(Peer reviewed; Journal article, 2021)Kompendiet er først og fremst rettet mot medisinstudenter, men kan leses av alle med interesse for feltet eller ønske om en kort repetisjon av embryologien. Det er kortfattet og nærmest stikkordspreget, i A4-størrelse og ... -
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006)
(Journal article, 2015)We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention-to-treat analysis with 36 months follow-up. ... -
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies
(Peer reviewed; Journal article, 2021)Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ... -
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
(Peer reviewed; Journal article, 2021)Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ... -
Deciphering role of succinate in metabolic rewiring of innate immunity
(Master thesis, 2021)Succinate is the anionic form of succinic acid, which is produced during adenosine triphosphate (ATP) synthesis via the tricarboxylic acid (TCA) cycle. In a biological system, succinate can be found in two forms. One is ... -
Deciphering the pathomolecular mechanisms underlying thoracic aortic aneurysm formation in syndromic patients
(Master thesis, 2022)A thoracic aortic aneurysm (TAA) is local dilatation that occurs in the major blood vessel from which blood flows to the aorta. In the worst case, weakened dilation can lead to rupture. Clinical decision making for the ... -
Decoding the Metabolic Reprogramming Underlying Toll-like Receptor Signaling
(Doctoral theses at NTNU;2021:297, Doctoral thesis, 2021) -
Decrease in use of manual vacuum aspiration in postabortion care in Malawi: A cross-sectional study from three public hospitals, 2008-2012
(Journal article; Peer reviewed, 2014)Objectives: To investigate the use of manual vacuum aspiration in postabortion care in Malawi between 2008–2012. Methods: A retrospective cross-sectional study was done at the referral hospital Queen Elisabeth Central ... -
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
(Journal article; Peer reviewed, 2023)Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ... -
Decreasing prevalence and severity of cerebral palsy in Norway among children born 1999 to 2010 concomitant with improvements in perinatal health
(Journal article; Peer reviewed, 2018)Background The aim of our study was to explore if the prevalence and clinical characteristics of cerebral palsy (CP), concomitant with perinatal health indicators in the general population, remained unchanged for children ... -
Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis
(Peer reviewed; Journal article, 2022)Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images ... -
Deep-inspiration breath-hold - Development and utilization of a deep-inspiration breath-hold system for breast cancer radiotherapy
(Doctoral theses at NTNU;2018:315, Doctoral thesis, 2018)The purpose of this thesis was to develop a deep-inspiration breath-hold (DIBH) system and study the performance and clinical implications in the treatment of leftsided breast cancer and radiotherapy. This was investigated ... -
Defining changes in the intestinal epithelium in early life and in response to infections
(Doctoral theses at NTNU;2021:231, Doctoral thesis, 2021)