Blar i Institutt for klinisk og molekylær medisin på tittel
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Comparison of surgical skill acquisition by UK surgical trainees and Sierra Leonean associate clinicians in a task-sharing programme
(Journal article; Peer reviewed, 2018)Background Task‐sharing in surgery is well established, with associate clinicians performing successful surgery in many countries. Little is known about the process of surgical skill acquisition by associate clinicians, ... -
Comparison of the associations between non-traditional and traditional indices of adiposity and cardiovascular mortality: an observational study of one million person-years of follow-up
(Journal article; Peer reviewed, 2019)Background/objective The most widely used adiposity index, body mass index (BMI), is not optimal to evaluate cardiovascular (CV) risk associated with overweight and obesity. We aimed to explore the association between ... -
Comparison of three point-of-care testing devices to detect hemostatic changes in adult elective cardiac surgery: A prospective observational study
(Journal article; Peer reviewed, 2014)Background: Bleeding complications in cardiac surgery may lead to increased morbidity and mortality. Traditional blood coagulation tests are not always suitable to detect rapid changes in the patient's coagulation status. ... -
Comparson og two methods for evaluation of tumor mass in multiple myeloma
(Master thesis, 2016)Background: The size of malignant tumours are in many instances proven or thought to mirror the risk of progression and/or death. In multiple myeloma, tumour cell mass can not be directly measured as the cells do not adhere ... -
Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis
(Peer reviewed; Journal article, 2019)Background: Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections, especially spontaneous bacterial peritonitis (SBP), leading to systemic inflammation that is associated with ... -
Compensatory mechanisms activated with intermittent energy restriction: a randomized trial
(Journal article; Peer reviewed, 2017)Background & aims Strong compensatory responses, with reduced resting metabolic rate (RMR), increased exercise efficiency (ExEff) and appetite, are activated when weight loss (WL) is achieved with continuous energy ... -
A Compilation of Serum Concentrations of 12 Antipsychotic Drugs in a Therapeutic Drug Monitoring Setting
(Peer reviewed; Journal article, 2019)Background: No comprehensive collection of routine therapeutic drug monitoring data for antipsychotic drugs has been published. Methods: In this compilation, data on 12 antipsychotics are presented. The drugs included ... -
Complement activation by cholesterol crystals triggers a subsequent cytokine response
(Journal article; Peer reviewed, 2017)In the host a diverse collection of endogenous danger signals is constantly generated consisting of waste material as protein aggregates or crystalline materials that are recognized and handled by soluble pattern recognition ... -
Complement Activation in 22q11.2 Deletion Syndrome
(Peer reviewed; Journal article, 2020)The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems ... -
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome.
(Journal article; Peer reviewed, 2016) -
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
(Peer reviewed; Journal article, 2021)Background Cardiopulmonary resuscitation after cardiac arrest initiates a whole-body ischemia-reperfusion injury, which may activate the innate immune system, including the complement system. We hypothesized that complement ... -
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
(Journal article; Peer reviewed, 2022) -
A complement C3–Specific nanobody for modulation of the alternative cascade identifies the C-Terminal domain of C3b as functional in C5 convertase activity
(Peer reviewed; Journal article, 2020)The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing ... -
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
(Journal article; Peer reviewed, 2018)There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully ... -
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
(Peer reviewed; Journal article, 2020)Inflammation is centrally involved in the development of cardiac hypertrophy and the processes of remodelling. The complement system and Toll-like receptor (TLR) family, two upstream arms of the innate immune system, have ... -
Complement component C5 and TLR molecule CD14 mediate heme-induced thromboinflammation in human blood
(Journal article; Peer reviewed, 2019)Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic ... -
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
(Journal article; Peer reviewed, 2017)Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors ... -
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
(Peer reviewed; Journal article, 2023)The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured ... -
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
(Journal article; Peer reviewed, 2017)Research during past decades made it evident that complement is involved in more tasks than fighting infections, but has important roles in other immune surveillance and housekeeping functions. If the balance between ... -
Complement in sepsis — when science meets clinics
(Peer reviewed; Journal article, 2020)Sepsis as life‐threatening organ dysfunction caused by microorganisms represents a dreadful challenge for the immune system. The role of the complement system as major column of innate immunity has been extensively studied ...