Browsing Institutt for klinisk og molekylær medisin by Title
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Cold agglutinin disease revisited: a multinational, observational study of 232 patients
(Peer reviewed; Journal article, 2020)We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in 5 countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we ... -
Colonic mucosal gene expression in inflammatory bowel disease: From whole genome to REG gene family expression
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:111, Doctoral thesis, 2013)Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the digestive tract. The two main forms of IBD are ulcerative colitis (UC) and Crohn’s disease (CD). As IBD are chronic diseases, often with ... -
Colorectal cancer patients’ experiences with supervised exercise during adjuvant chemotherapy—A qualitative study
(Peer reviewed; Journal article, 2021)Background Colorectal cancer (CRC) is a common cancer worldwide, with increasing numbers surviving and living with long-term side effects from treatment. Physical exercise during or after treatment may have several beneficial ... -
Colorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial
(Peer reviewed; Journal article, 2020)Background and aims: The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. Methods: Individuals aged 50-74 years living in South-East Norway ... -
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
(Peer reviewed; Journal article, 2023)Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ... -
Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2
(Peer reviewed; Journal article, 2022)Three directly acting antivirals (DAAs) demonstrated substantial reduction in COVID-19 hospitalizations and deaths in clinical trials. However, these agents did not completely prevent severe illness and are associated with ... -
Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer
(Journal article; Peer reviewed, 2017)The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ... -
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
(Peer reviewed; Journal article, 2021)Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism of xenograft rejection. We hypothesized ... -
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
(Journal article; Peer reviewed, 2018)Background: Meconium aspiration syndrome (MAS) is a severe lung condition affecting newborns and it can lead to a systemic inflammatory response. We previously documented complement activation and cytokine release in a ... -
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
(Journal article; Peer reviewed, 2017)Background Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key ... -
Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing the toll-like receptor 4-MD2 complex
(Journal article; Peer reviewed, 2016)Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including TLR4 and TLR2. The aim of this study was to investigate the effect ... -
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
(Peer reviewed; Journal article, 2015)Introduction Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of innate immunity recognition systems including complement and the Toll-like receptor family initiate this disproportionate ... -
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase
(Journal article; Peer reviewed, 2012)X-ray crystallography provides excellent structural data on protein–DNA interfaces, but crystallographic complexes typically contain only small fragments of large DNA molecules. We present a new approach that can use longer ... -
Combining optimal nutrition and exercise in a multimodal approach for patients with active cancer and risk for losing weight: Rationale and practical approach
(Journal article; Peer reviewed, 2019)Weight loss and functional decline is a common and detrimental consequence of cancer. The interventions that are offered to patients with weight loss and functional decline often seem haphazard and varying from center to ... -
Common Core Assessments in follow‐up studies of adults born preterm—Recommendation of the Adults Born Preterm International Collaboration
(Journal article; Peer reviewed, 2020) -
Common nodes of virus–host interaction revealed through an integrated network analysis
(Journal article; Peer reviewed, 2019)Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ... -
Commonly prescribed medicines interfere with cellular response to influenza A virus infection
(Master thesis, 2021)Bakgrunn Hvert år blir millioner av mennesker smittet med influensa A-virus. Mange av disse menneskene har underliggende kroniske sykdommer, slik som leddgikt, diabetes og høyt blodtrykk, og er derfor avhengige av medisinsk ... -
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
(Journal article; Peer reviewed, 2019)The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ... -
Comorbidities in cerebral palsy: a patient registry study
(Journal article; Peer reviewed, 2019)Aim To describe the total burden of disease in individuals with cerebral palsy (CP) in Norway. Method A comprehensive set of disorder categories were extracted from the Norwegian Patient Registry using International ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
(Journal article; Peer reviewed, 2016)Background: Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. ...