Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 507-526 of 3430
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Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies
(Peer reviewed; Journal article, 2020)Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can be complicated with fetal growth restriction ... -
Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
(Journal article; Peer reviewed, 2019)Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we ... -
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
(Peer reviewed; Journal article, 2020)Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ... -
Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized
(Journal article; Peer reviewed, 2018)Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ... -
Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines
(Journal article; Peer reviewed, 2014)Background Deciphering the most common modes by which chromatin regulates transcription, and how this is related to cellular status and processes is an important task for improving our understanding of human cellular ... -
Chronic diseases: what about infections of virus and prions via the gut?
(Peer reviewed; Journal article, 2021) -
Chronic fatigue in long-term survivors of Hodgkin’s lymphoma after contemporary risk-adapted treatment
(Peer reviewed; Journal article, 2023)Background Chronic fatigue (CF), substantial fatigue for ≥ six months, can manifest as a late effect (LE) after cancer treatment, and may affect several aspects of life. In a Norwegian cohort of Hodgkin’s lymphoma ... -
Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway
(Journal article; Peer reviewed, 2024)Purpose: Bloodstream infections (BSI) and sepsis are important causes of hospitalization, loss of health, and death globally. Targetable risk factors need to be identified to improve prevention and treatment. In this study, ... -
Chronic Non-Specific Pain in Adolescence Prevalence, Disability, and Associated Factors: Young-HUNT and HUNT 3, 2006-2008
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:328, Doctoral thesis, 2012)Kronisk uspesifikk smerte hos ungdom - Prevalens og assosierte faktorer Ung-HUNT og HUNT 3, 2006-2008 Bakgrunn: Kronisk uspesifikk smerte er hyppig forekommende blant barn og ungdom, og prevalensen ser ut til å være økende. ... -
Chronic pain in the general population: Measurement, burden and associations with physical activity: – The HUNT pain study –
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:148, Doctoral thesis, 2013) -
Chronic vulvar pain in gynecological outpatients
(Peer reviewed; Journal article, 2022)Objectives Chronic vulvar pain (CVP) is pain in the vulvar area exceeding three months of duration. Previous studies have reported a prevalence of 7–8% in the general population and observed an association between CVP and ... -
Chronic wounds in sierra leone: Searching for buruli ulcer, a ntd caused by mycobacterium ulcerans, at masanga hospital
(Peer reviewed; Journal article, 2021)Chronic wounds constitute a significant surgical burden to low- and middle-income countries; however, their aetiology often remains poorly understood. This study improves our understanding of wound aetiology through tissue ... -
CImbinator: a web-based tool for drug synergy analysis in small- and large-scale datasets
(Journal article; Peer reviewed, 2017)Motivation: Drug synergies are sought to identify combinations of drugs particularly beneficial. User-friendly software solutions that can assist analysis of large-scale datasets are required. Results: CImbinator is a ... -
Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training
(Peer reviewed; Journal article, 2020)MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In women with polycystic ovary syndrome (PCOS), several miRNAs are differentially expressed compared to women without PCOS, ... -
Circulating calprotectin: from measurement to clinical application - studies of preanalytical, analytical, and cardiovascular biomarker performance
(Doctoral theses at NTNU;2024:161, Doctoral thesis, 2024)Norsk sammendrag Hjerte-karsykdom er en svært vanlig årsak til sykdom og tidlig død på verdensbasis og skyldes i hovedsak åreforkalkning (aterosklerose) som oppstår pga. fettavleiringer og inflammasjon i åreveggene. ... -
Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia
(Peer reviewed; Journal article, 2022)Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component ... -
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
(Peer reviewed; Journal article, 2023)Background Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized ... -
Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
(Peer reviewed; Journal article, 2022)The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the ... -
Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model
(Journal article; Peer reviewed, 2021)There is an incomplete understanding of the underlying pathophysiology in hypertensive emergencies, where severely elevated blood pressure causes acute end-organ injuries, as opposed to the long-term manifestations of ...