Blar i Institutt for klinisk og molekylær medisin på tittel
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Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer
(Journal article; Peer reviewed, 2016)Background: Concurrent chemotherapy and thoracic radiotherapy (TRT) is recommended for limited disease small cell lung cancer (LD SCLC). Twice daily TRT is well documented, but not universally implemented – probably mainly ... -
Randomized phase III trial comparing switch-maintenance pemetrexed with observation followed by pemetrexed at progression in advanced NSCLC
(Peer reviewed; Journal article, 2020)Objectives: Two phase III trials show that maintenance pemetrexed therapy after platinum-doublet chemotherapy prolongs overall survival (OS) and progression free survival (PFS) in advanced non-squamous non-small-cell lung ... -
A randomized study of the effect of patient positioning on setup reproducibility and dose distribution to organs at risk in radiotherapy of rectal cancer patients
(Peer reviewed; Journal article, 2015)Background:The patient positioning in pelvic radiotherapy (RT) should be decided based on both reproducibilityand on which position that yields the lowest radiation dose to the organs at risk (OAR), and thereby less ... -
Ranking of substances for monitoring in foods, drinks and dietary supplements - based on risk and knowledge gaps
(VKM Report;, Research report, 2019)The Norwegian Food Safety Authority (NFSA) requested the Norwegian Scientific Committee for Food and Environment (VKM) to provide an overview of substances in foods, drinks and dietary supplements that may constitute a ... -
Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis
(Journal article; Peer reviewed, 2017)Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were ... -
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
(Journal article; Peer reviewed, 2021)Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, ... -
Rates of subjective and objective cure, satisfaction, and pain 10–20 years after tension-free vaginal tape (TVT) surgery: A retrospective cohort study
(Peer reviewed; Journal article, 2023)Objective To evaluate rates of subjective and objective cure, treatment satisfaction, pain, and the correlation between cure and body mass index (BMI), at 10 and 20 years after tension-free vaginal tape (TVT) surgery. ... -
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI).
(Journal article; Peer reviewed, 2019)Introduction Interleukin-6 (IL-6) may be involved in ischaemia-reperfusion injury and myocardial remodelling after myocardial infarction (MI). We have recently shown that IL-6 inhibition by tocilizumab attenuates systemic ... -
Re-assessment of the plant protection product PROMAN – with the active ingredient metobromuron. Opinion of the Panel on Plant Protection Products of the Norwegian Scientific Committee for Food Safety
(VKM Report;, Research report, 2015)Proman is a broad spectrum selective herbicide for potatoes grown outdoors, containing the active substance metobromuron. VKM’s Panel on Plant Protection Products has previously discussed questions concerning Proman raised ... -
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro
(Journal article; Peer reviewed, 2014)Abstract. Photodynamic therapy (PDT) and photodiagnosis based on the intracellular production of the photosensitizer protoporphyrin IX (PPIX) by administration of its metabolic precursor δ-aminolevulinic acid (ALA) achieved ... -
Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study
(Peer reviewed; Journal article, 2022)Background Etanercept (ETN) and adalimumab (ADA) are considered equally effective biologicals in the treatment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported ... -
Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer
(Peer reviewed; Journal article, 2023)Objectives The aim of this study was to provide real-world efficacy and safety data on niraparib maintenance treatment in patients with non-germline (gBRCA)1/2 mutated platinum-sensitive recurrent ovarian cancer. Methods ... -
Reasons for prolonged time for diagnostic workup for stage I-II lung cancer and estimated effect of applying an optimized pathway for diagnostic procedures
(Journal article; Peer reviewed, 2019)Background:Minimizing the time until start of cancer treatment is a political goal. In Norway, the target time forlung cancer is 42 days. The aim of this study was to identify reasons for delays and estimate the effect on ... -
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids
(Peer reviewed; Journal article, 2022)Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. ... -
Receptor binding competition: A paradigm for regulating TGF-β family action
(Peer reviewed; Journal article, 2020)The transforming growth factor (TGF)-β family is a group of structurally related, multifunctional growth factors, or ligands that are crucially involved in the development, regulation, and maintenance of animal tissues. ... -
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification
(Journal article; Peer reviewed, 2019)The wobble hypothesis was proposed to explain the presence of fewer tRNAs than possible codons. The wobble nucleoside position in the anticodon stem-loop undergoes a number of modifications that help maintain the efficiency ... -
Recommendations for the FAIRification of genomic track metadata
(Journal article; Peer reviewed, 2021) -
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
(Journal article; Peer reviewed, 2015)Chronic inflammation of the arterial wall is a key element in the development of atherosclerosis, and cholesterol crystals (CC) that accumulate in plaques are associated with initiation and progression of the disease. We ... -
Record linkage as a vital key player for the COVID-19 syndemic – The call for legal harmonization to overcome research challenges
(Peer reviewed; Journal article, 2023)The initial public health response to the COVID-19 pandemic aimed to prevent exponential dissemination and circumvent drastic collapses of healthcare systems [1]. Containment measures and required isolation promoted sedentary ... -
Recovery trajectories in common musculoskeletal complaints by diagnosis contra prognostic phenotypes
(Peer reviewed; Journal article, 2021)Background There are large variations in symptoms and prognostic factors among patients sharing the same musculoskeletal (MSK) diagnosis, making traditional diagnostic labelling not very helpful in informing treatment ...