Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2090-2109 av 3430
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Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
(Peer reviewed; Journal article, 2020)The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expression are associated with carcinogenesis and cancer treatment outcomes. ... -
MRI in the Assessment of TMJ-Arthritis in Children with JIA; Repeatability of a Newly Devised Scoring System
(Peer reviewed; Journal article, 2021)Rationale and Objectives: The temporomandibular joint (TMJ) is commonly involved in children with juvenile idiopathic arthritis. The diagnosis and evaluation of the disease progression is dependent on medical imaging. The ... -
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity
(Journal article; Peer reviewed, 2015)Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ... -
MRI-based radiomic signatures for pretreatment prognostication in cervical cancer
(Peer reviewed; Journal article, 2023)Background Accurate pretherapeutic prognostication is important for tailoring treatment in cervical cancer (CC). Purpose To investigate whether pretreatment MRI-based radiomic signatures predict disease-specific ... -
MRPL28: A New Candidate Gene for Aerobic Capacity
(Master thesis, 2015)Large-scale epidemiological studies demonstrate that aerobic capacity, measured as maximal oxygen uptake (VO2max), is the single best predictor for future cardiovascular mortality in both healthy individuals and patients ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
(Peer reviewed; Journal article, 2020)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ... -
MS-proteomics provides insight into the host responses towards alginate microspheres
(Journal article; Peer reviewed, 2022)Protein adsorption to biomaterial surfaces is considered a determining factor for the host response. Here we detail the protein adsorption profiles of alginate hydrogel microspheres relevant for cell therapy using mass ... -
MTHFR C677T and A1298C polymorphism’s effect on risk of colorectal cancer in Lynch syndrome
(Peer reviewed; Journal article, 2023)Lynch syndrome (LS) is characterised by an increased risk of developing colorectal cancer (CRC) and other extracolonic epithelial cancers. It is caused by pathogenic germline variants in DNA mismatch repair (MMR) genes or ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
(Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
(Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
(Journal article, 2014)Background: Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
(Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
(Peer reviewed; Journal article, 2022)COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ... -
Multimodal 18F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma
(Journal article; Peer reviewed, 2017)Background Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma. Because of the heterogeneous nature of gliomas, ... -
A multiomics disease progression signature of low-risk ccRCC
(Peer reviewed; Journal article, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
Multiparametric Characterization of Response to Anti-angiogenic Therapy Using USPIO Contrast-enhanced MRI in Combination with Dynamic Contrast-enhanced MRI
(Journal article, 2017)Background Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. Purpose To investigate the utility of the ultrasmall superparamagnetic iron oxide particles ... -
Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies
(Peer reviewed; Journal article, 2021)Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ... -
Multiple Functions of Base Excision Repair Proteins: Relevance to RNA Quality Control and B-Cell Lymphomagenesis
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:325, Doctoral thesis, 2014) -
Multiple layers of gene regulation: the cell cycle, epigenetics and microRNAs
(Doctoral thesis at NTNU;2015:73, Doctoral thesis, 2015)