Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2029-2048 av 3426
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MicroRNAs in cell cycle regulation and DNA repair
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:94, Doctoral thesis, 2013) -
Microvascular proliferation in luminal A and basal-like breast cancer subtypes
(Journal article; Peer reviewed, 2015)Aims The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) and luminal A subtypes of breast cancer and to study their ... -
A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines
(Peer reviewed; Journal article, 2020)Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and ... -
Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS)
(Peer reviewed; Journal article, 2020)Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ... -
Miljørisikovurdering av genmodifisert mais MON 88017 Monsanto Company (EFSA/GMO/CZ/2008/54). 1. innspillsrunde. Uttalelse fra Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet
(VKM Report;, Research report, 2010)Miljørisikovurderingen av den insektresistente og herbicidtolerante maislinjen MON 88017 (EFSA/GMO/CZ/2008/54) fra Monsanto er utført av Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet (VKM). ... -
Miljørisikovurdering genmodifisert mais MON 89034 x NK603 fra Monsanto Company (EFSA/GMO/NL/2009/72). Uttalelse fra Faggruppe for genmodifiserte organismer Vitenskapskomiteen for mattrygghet
(VKM Report;, Research report, 2010)Helse- og miljørisikovurderingen av den insektresistente og herbicidtolerante maishybriden MON 89034 x NK603 (EFSA/GMO/NL/2009/72) fra Monsanto Company er utført av Faggruppe for genmodifiserte organismer i Vitenskapskomiteen ... -
Minimal important differences and response shift in health-related quality of life; a longitudinal study in patients with multiple myeloma
(Journal article; Peer reviewed, 2010)Background: We previously reported that changes of 6-17 percent in the EORTC QLQ-C30 scores are regarded important by patients with multiple myeloma and thus may be considered as Minimal Important Differences (MIDs). ... -
The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST)
(Peer reviewed; Journal article, 2020)Motivation A large variety of molecular interactions occurs between biomolecular components in cells. When a molecular interaction results in a regulatory effect, exerted by one component onto a downstream component, a ... -
miRNA and mRNA expression in the hippocampal region during postnatal developments in rats
(Doctoral theses at NTNU;2018:66, Doctoral thesis, 2018)Hjernestrukturene entorhinal cortex og hippocampus er viktige for minnefunksjon og navigering. Innenfor hver av disse strukturene finnes underregioner som har forskjellige celletyper og forbindelser i hjernen. Noen av ... -
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
(Peer reviewed; Journal article, 2021)While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. ... -
Mitochondrial genome-wide association study of migraine – the HUNT Study
(Peer reviewed; Journal article, 2020)Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ... -
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
(Journal article; Peer reviewed, 2015)Objective: To provide novel insights on mitochondrial respiration in β-cells and the adaptive effects of hypoxia. Methods and Design Insulin-producing INS-1 832/13 cells were exposed to 18 hours of hypoxia followed by ... -
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
(Peer reviewed; Journal article, 2023)Mitotic entry correlates with the condensation of the chromosomes, changes in histone modifications, exclusion of transcription factors from DNA, and the broad downregulation of transcription. However, whether mitotic ... -
Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
(Journal article; Peer reviewed, 2020)Recent experimental studies indicated that a periodontitis-causing bacterium might be a causal factor for Alzheimer’s disease (AD). We applied a two-sample Mendelian randomization (MR) approach to examine the potential ... -
MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection
(Journal article; Peer reviewed, 2023)Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells. All three pathways share ... -
Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection
(Peer reviewed; Journal article, 2023)Intestinal epithelial homeostasis is maintained by intrinsic and extrinsic signals. The extrinsic signals include those provided by mesenchymal cell populations that surround intestinal crypts and is further facilitated ... -
Modeling neurodevelopment in 2D and 3D cultures with different DNA glycosylase backgrounds
(Master thesis, 2019)The brain is under constant attack from exogenous and endogenous sources of DNA damage, and due to the non-proliferative identity of the neuronal cells, a highly functional repair systems need to be in place. One of the ... -
Modeling Obesity in Norway (The MOON Study): A Decision-Analytic Approach—Prevalence, Costs, and Years of Life Lost
(Peer reviewed; Journal article, 2020)Background. Limited knowledge exists on the expected long-term effects and cost-effectiveness of initiatives aiming to reduce the burden of obesity. Aim. To develop a Norwegian obesity-focused disease-simulation model: the ... -
Modelling the landscape of palliative care for people with dementia: a European mixed methods study
(Journal article; Peer reviewed, 2013)Background Palliative care for people with dementia is often sub-optimal. This is partly because of the challenging nature of dementia itself, and partly because of system failings that are particularly salient in primary ... -
Moderate continuous or high intensity interval exercise in heart failure with reduced ejection fraction: Differences between ischemic and non-ischemic etiology
(Peer reviewed; Journal article, 2022)Background Exercise for heart failure (HF) with reduced ejection fraction (HFrEF) is recommended by guidelines, but exercise mode and intensities are not differentiated between HF etiologies. We, therefore, investigated ...