Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1943-1962 av 3589
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Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages
(Peer reviewed; Journal article, 2019)Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ... -
Lenalidomide versus lenalidomide + dexamethasone prolonged treatment after second-line lenalidomide + dexamethasone induction in multiple myeloma
(Journal article; Peer reviewed, 2018)Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single‐agent Len may be effective as prolonged treatment regimen in RRMM once ... -
Levator ani muscle injury and risk for urinary and fecal incontinence in parous women from a normal population, a cross-sectional study
(Journal article; Peer reviewed, 2019)Aims To study possible associations between levator ani muscle (LAM) injury and urinary incontinence (UI) and fecal incontinence (FI) and possible associations between bladder neck descent (BND), urethral funneling, and ... -
Levator ani muscle morphology and function in women with obstetric anal sphincter injury
(Peer reviewed; Journal article, 2019)Objectives To estimate the prevalence of, and explore the risk factors for, levator ani muscle (LAM) injury in women with clinically diagnosed obstetric anal sphincter injury (OASI). The secondary aim was to assess the ... -
Life after adolescent and adult moderate and severe traumatic brain injury: self-reported executive, emotional, and behavioural function 2-5 years after injury
(Peer reviewed; Journal article, 2015)Survivors of moderate-severe Traumatic Brain Injury (TBI) are at risk for long-term cognitive, emotional, and behaviouralproblems. This prospective cohort study investigated self-reported executive, emotional, and behavioural ... -
Lifestyle behavior among lymphoma survivors after high-dose therapy with autologous hematopoietic stem cell transplantation, assessed by patient-reported outcomes
(Journal article; Peer reviewed, 2019)Introduction: High-dose therapy with autologous stem cell transplantation (HD-ASCT) is associated with an increased risk of late effects. Our aim was to assess lifestyle behavior and factors associated with unhealthy ... -
Lifestyle modification for weight loss: Effects on cardiorespiratory capacity in patients with class II and class III obesity
(Journal article; Peer reviewed, 2021)Background: The prevalence of obesity has increased worldwide. Obesity affectsthe lungs and airways, limits peak oxygen uptake, and hampers physical perfor-mance; however, objective data are scarce. Does lifestyle modification ... -
Limited effect of red blood cell transfusion on long-term mortality among anaemic cardiac surgery patients
(Peer reviewed; Journal article, 2020)OBJECTIVES Our goal was to investigate long-term mortality associated with red blood cell (RBC) transfusion among patients with anaemia undergoing cardiac surgery when adjusting for known risk factors. METHODS Adults with ... -
Limited microstructural and connectivity deficits despite subcortical volume reductions in school-aged children born preterm with very low birth weight.
(Journal article; Peer reviewed, 2015)Preterm birth and very low birth weight (VLBW, ≤ 1500 g) are worldwide problems that burden survivors with lifelong cognitive, psychological, and physical challenges. In this multimodal structural magnetic resonance imaging ... -
Linguistic and content validation of the translated and culturally adapted PG-SGA, as perceived by Norwegian cancer patients and healthcare professionals
(Peer reviewed; Journal article, 2020)Background & aims The Scored Patient-Generated Subjective Global Assessment (PG-SGA©) is a validated nutritional screening, assessment, monitoring, and triage tool. When translated to other languages, the questions and ... -
Lipid droplets hypertrophy: A crucial determining factor in insulin regulation by adipocytes
(Journal article; Peer reviewed, 2015)Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with ... -
Lipid droplets in hepatitis C virus-infected hepatocytes – exploring the role of TANK-binding kinase 1 and autophagy
(Master thesis, 2020)Hepatisk steatose defineres som opphoping av lipider i lipiddråper i hepatocytter, og er en betydelig årsak til levercirrhose og alvorlig leversykdom. Hepatitt C-virus (HCV) forårsaker steatose, men mekanismene som regulerer ... -
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016
(Peer reviewed; Journal article, 2023)Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration ... -
Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection
(Journal article; Peer reviewed, 2014)Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity ... -
Lipocalin 2 is expressed in MLO-Y4 osteocytes and regulated by the peroxisome proliferator activated receptor α agonist fenofibrate.
(Master thesis, 2020)Background: Lipocalin 2 is highly expressed and secreted from osteoblasts in mice. Lately, bone-derived lipocalin 2 has been shown to suppress appetite by binding to the MC4R in hypothalamus. In the present study we wanted ... -
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
(Journal article; Peer reviewed, 2023)Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
(Peer reviewed; Journal article, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma
(Journal article; Peer reviewed, 2023)Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ... -
Live born recipient of twin-twin transfusion syndrome with anomalous mitral arcade
(Peer reviewed; Journal article, 2019)We present a case report of anomalous mitral arcade in a live born former recipient of twin-twin transfusion syndrome. At 33+0 week of gestation fetal ultrasound demonstrated that she had a large mitral insufficiency, ... -
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile
(Peer reviewed; Journal article, 2020)Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different ...