Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates 

      Hals, Ingrid Kathrin; Ohki, Tsuyoshi; Singh, Rinku; Ma, Zuheng; Björklund, Anneli; Balasuriya, Chandima Nirupa Dilruks; Scholz, Hanne; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)
      We previously showed that hyperoxia in vitro negatively affects beta cells of the rat. Here, we tested for possible clinical significance as well as mitochondrial interactions by hyperoxia, using human islets (function and ...

    • Hyperspectral characterization of an in vitro wound model 

      Randeberg, Lise Lyngsnes; Hegstad, Janne-Lise A; Paluchowski, Lukasz A.; Milanic, Matija; Pukstad, Brita (Journal article; Peer reviewed, 2014)
      Wound healing is a complex process not fully understood. There is a need of better methods to evaluate the different stages of healing, and optical characterization is a promising tool in this respect. In this study ...

    • Hyperspectral characterization of re‐epithelialization in an in vitro wound model 

      Bjorgan, Asgeir; Pukstad, Brita Solveig; Randeberg, Lise Lyngsnes (Peer reviewed; Journal article, 2020)
      In vitro wound models are useful for research on wound re‐epithelialization. Hyperspectral imaging represents a non‐destructive alternative to histology analysis for detection of re‐epithelialization. This study aims to ...

    • Hyperspectral imaging of atherosclerotic plaques in vitro 

      Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Olstad, Elisabeth; Haugen, Olav Anton; Aksnes, Astrid; Svaasand, Lars O. (Journal article; Peer reviewed, 2011)
      Vulnerable plaques constitute a risk for serious heart problems, and are difficult to identify using existing methods. Hyperspectral imaging combines spectral- and spatial information, providing new possibilities for precise ...

    • Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics 

      Hallan, Stein; Øvrehus, Marius Altern; Bjørneklett, Rune; Aasarød, Knut Ivar; Fogo, Agnes B.; Ix, Joachim H. (Peer reviewed; Journal article, 2020)
      Background. Hypertensive nephrosclerosis is the presumed underlying cause in many end-stage kidney disease (ESKD) patients, but the diagnosis is disputed and based on clinical criteria with low diagnostic accuracy. Objective. ...

    • Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors 

      Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Egeland, Grace M.; Nygård, Ottar; Selmer, Randi Marie; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Peer reviewed; Journal article, 2019)
      Background and aim Hypertensive pregnancy disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate ...

    • Hypoglycemia in adults with Type 1 Diabetes Mellitus: Investigating symptoms and awareness of hypoglycemia and the association between impaired awareness of hypoglycemia, autonomic neuropathy and cognition 

      Olsen, Sandra Elise (Doctoral theses at NTNU;2016:317, Doctoral thesis, 2016)
      Hypoglycemia is still the main limitation for the management of Type 1 diabetes mellitus (T1DM). If it were not for hypoglycemia, treatment of T1DM would be easy. Subjects with T1DM have impaired defense mechanisms against ...

    • Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss 

      Zahoor, Muhammad; Westhrin, Marita; Aass, Kristin Roseth; Moen, Siv Helen; Misund, Kristine; Psonka-Antonczyk, Katarzyna Maria; Giliberto, Mariaserena; Buene, Glenn; Sundan, Anders; Waage, Anders; Sponaas, Anne-Marit; Standal, Therese (Journal article; Peer reviewed, 2017)
      Multiple myeloma (MM) is a hematologic cancer characterized by expansion of malignant plasma cells in the bone marrow. Most patients develop an osteolytic bone disease, largely caused by increased osteoclastogenesis. The ...

    • Hysterektomi i Norge 2008–18 

      Johanson, Maja Lieng; Dögl, Malin Andrea Elisabeth; Lieng, Marit (Peer reviewed; Journal article, 2020)
      Background: Hysterectomy is a common gynaecological procedure. No Norwegian guidelines for the choice of hysterectomy surgical method exist, but international guidelines recommend minimally invasive surgery. The objective ...

    • Hysterektomi ved St. Olavs hospital 1989-2014 

      Denstad, Silje Eilertsen; Aasen, Silje; Østrem, Anette; Bakkeheim, Vivi; Fossum, Guro Haugen; Moen, Mette Haase (Journal article; Peer reviewed, 2017)
      BAKGRUNN Hysterektomi er en av de vanligste gynekologiske operasjonene. Operasjonsmetodene har endret seg de siste decenniene. Nye utredningsmuligheter og alternative behandlingsmetoder har kommet til. Hensikten med denne ...

    • Hysterotomy level at cesarean section and occurrence of large scar defects: a randomized single-blind trial 

      Vikhareva, Olga; Skott Rickle, G; Lavesson, T; Nedopekina, E; Brandell, K; Salvesen, Kjell Å (Peer reviewed; Journal article, 2019)
      Objective To study the association between the level of Cesarean hysterotomy and the presence of large uterine scar defects 6–9 months after delivery. Methods This was a two-center, randomized, single-blind trial of ...

    • Høy forekomst av Mycoplasma genitalium hos kvinner under 25 år: Prevalensundersøkelse av M. genitalium i pasientprøver som testes for C. trachomatis 

      Fardal, Hilde; Törneke, Ulrika (Master thesis, 2012)
      Formål med studien: Å kartlegge forekomsten av M. genitalium infeksjoner blant en uselektert gruppe pasienter som skal testes for C. trachomatis. Forekomsten av mørketall for M. genitalium ved diagnostikk av C. trachomatis ...

    • Høyt nivå av tungmetaller i krabbe 

      Averina, Maria; Monsen, Anne-Lise Bjørke; Bolann, Bjørn Johan; Brox, Jan; Eggesbø, Merete; Hokstad, Ingrid; Huber, Sandra; Ørebech, Peter Th (Journal article; Peer reviewed, 2022)

    • I jordmors hender - En kvalitativ studie om kvinners opplevelse av å føde på en jordmorstyrt enhet 

      Braseth, Kristin.; Auran, K, Linda. (Master thesis, 2022)
      Bakgrunnen for studien er at det sees en økende medikalisering innen den moderne fødselsomsorgen. Dette utgjør en risiko for økt forekomst av intervensjoner i fødselsforløpet, noe som kan ha påvirkning på hvilken opplevelse ...

    • I jordmors hender- En kvalitativ studie om kvinners opplevelse av å føde på en jordmorstyrt enhet 

      Auran, Linda Krakeli; Braseth, Kristin (Master thesis, 2022)
      Bakgrunnen for studien er at det sees en økende medikalisering innen den moderne fødselsomsorgen. Dette utgjør en risiko for økt forekomst av intervensjoner i fødselsforløpet, noe som kan ha påvirkning på hvilken opplevelse ...

    • Icotinib is an active treatment of non-small-cell lung cancer: A retrospective study 

      Chen, X; Zhu, Q; Liu, Y; Liu, P; Yin, Y; Guo, R; Lu, K; Gu, Y; Liu, L; Wang, J; Wang, Z; Røe, Oluf Dimitri; Shu, Y; Zhu, L (Journal article; Peer reviewed, 2014)
      Background Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small cell lung cancer (NSCLC). This retrospective ...

    • Identification and Tracking of Antiviral Drug Combinations 

      Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)
      Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...

    • Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant 

      Wang, Qiang; Martínez-Bonet, Marta; Kim, Taehyeung; Sparks, Jeffrey A.; Ishigaki, Kazuyoshi; Chen, Xiaoting; Sudman, Marc; Aguiar, Vitor; Sim, Sangwan; Hernandez, Marcos Chiñas; Chiu, Darren J.; Wactor, Alexandra; Wauford, Brian; Marion, Miranda C.; Gutierrez-Arcelus, Maria; Bowes, John; Eyre, Stephen; Nordal, Ellen Berit; Prahalad, Sampath; Rygg, Marite; Videm, Vibeke; Raychaudhuri, Soumya; Weirauch, Matthew T.; Langefeld, Carl D.; Thompson, Susan D.; Nigrovic, Peter A. (Peer reviewed; Journal article, 2023)
      TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with ...

    • Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library. 

      Ertesvåg, Helga; Sletta, Håvard; Senneset, Mona; Sun, Yi-Qian; Klinkenberg, Geir; Konradsen, Therese Aursand; Ellingsen, Trond E; Valla, Svein (Journal article; Peer reviewed, 2017)
      BACKGROUND: Polysaccharides often are necessary components of bacterial biofilms and capsules. Production of these biopolymers constitutes a drain on key components in the central carbon metabolism, but so far little is ...

    • Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients 

      Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein; Pigni, Alessandra; Brunelli, Cinzia; Roberto, Anna; Piazza, Rocco; Pirola, Alessandra; Gambacorti-Passerini, Carlo; Caraceni, Augusto Tomasso Giovanni (Peer reviewed; Journal article, 2020)
      Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ...