Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1242-1261 av 3426
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Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—a Population-Based Study
(Peer reviewed; Journal article, 2021)Simple summary: Stomach cancer may be missed during upper endoscopy. We have examined how often this occurs and identified factors associated with missed cancers. Among 730 patients with gastric cancer, 67 (9.2%) were ... -
Gastric Carcinomas Localized to the Cardia
(Journal article; Peer reviewed, 2012)Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
(Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Gastric neuroendocrine cells - role in gastric neoplasia in man and rodents
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:183, Doctoral thesis, 2010)In paper I we showed that neuroendocrine markers could be found in signet ring cancer cells, a cell type thought to originate from exocrine committed cells and thus these tumours have previously been classified as ... -
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
(Journal article; Peer reviewed, 2017)Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ... -
Gastrin and gastric cancer
(Journal article; Peer reviewed, 2017)Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced ... -
Gastrin induced autophagy in gastric adenocarcinoma cells
(Master thesis, 2014)The Gastroenterology and Cell biology research group at NTNU studies the role of gastrin in gastric cancer. Gastrin is shown to be involved in proliferation, anti-apoptosis, migration, invasion and angiogenesis. The role ... -
Gastrin regulated activation of proteins in the elF2α-p-ATF4 network
(Master thesis, 2013)This master's thesis is a part of a research project of The Gastroenterology Cell Biology Group investigating molecular responses to gastrin induced gene expression, with focus on how duration and intensity of gastrin ... -
Gastrin-mediated regulation of gene expression; a systems biology approach
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:336, Doctoral thesis, 2012)Gastrin-regulert genuttrykk; en systembiologisk tilnærming I tillegg til å være det viktigste hormonet som kontrollerer utskillelsen av magesyre (saltsyre, HCl), er gastrin også involvert i vekstregulering av mageslimhinnen. ... -
Gastritis, Gastric Polyps and Gastric Cancer
(Peer reviewed; Journal article, 2021)Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction ... -
Gastrointestinal hormones and appetite ratings after weight loss induced by diet or bariatric surgery
(Peer reviewed; Journal article, 2023)Objective The aim of this study was to compare changes in gastrointestinal hormones and appetite ratings after a similar weight loss induced by a very low-energy diet alone or in combination with sleeve gastrectomy (SG) ... -
Gefitinib or Erlotinib as Maintenance Therapy in Patients with Advanced Stage Non-Small Cell Lung Cancer: A Systematic Review
(Journal article; Peer reviewed, 2013)Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), gefitinib and erlotinib have been tested as maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC). The ... -
Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks
(Journal article; Peer reviewed, 2017)Background Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems—the PAXgene and Tempus tubes—differently influence RNA expression signatures. The aim ... -
Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort
(Journal article; Peer reviewed, 2021)Active smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes ... -
Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells
(Journal article; Peer reviewed, 2012)It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened ... -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
(Journal article; Peer reviewed, 2015)Non-sterile pathogen-induced sepsis and sterile inflammation like in trauma or ischemia–reperfusion injury may both coincide with the life threatening systemic inflammatory response syndrome and multi-organ failure. ... -
Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis
(Journal article; Peer reviewed, 2019)Introduction Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted ... -
Gene expression studies in gastrointestinal pathophysiology and neoplasia
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:89, Doctoral thesis, 2006) -
Gene Network Inference and Biochemical Assessment Delineates GPCR Pathways and CREB Targets in Small Intestinal Neuroendocrine Neoplasia
(Journal article; Peer reviewed, 2011)Small intestinal (SI) neuroendocrine tumors (NET) are increasing in incidence, however little is known about their biology. High throughput techniques such as inference of gene regulatory networks from microarray experiments ... -
Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort
(Journal article; Peer reviewed, 2013)Transcription factors control which information in a genome becomes transcribed to produce RNAs that function in the biological systems of cells and organisms. Reliable and comprehensive information about transcription ...