Browsing Institutt for klinisk og molekylær medisin by Title
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Effects of a fall prevention program in elderly: A pragmatic observational study in two orthopedic departments
(Journal article; Peer reviewed, 2019)Purpose: Falls are a common adverse event experienced by elderly in hospitals. This study assessed the effects of a fall prevention program on the rate of fallers, the patient safety culture, and patient-perceived ... -
Effects of Adrenaline on maternal and fetal fentanyl absorption in epidural analgesia: a randomized trial
(Journal article; Peer reviewed, 2018)Background The combination of low‐dose local anesthesia and lipophilic opioids such as fentanyl is established as a standard solution for labor epidural analgesia. Fentanyl increases efficacy, but may have negative effects ... -
Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine
(Journal article; Peer reviewed, 2017)Objective To investigate serum concentrations of second-generation antipsychotics in relation to age and gender in a population ranging from 18 to 100 years. Method Results from a routine therapeutic drug monitoring ... -
Effects of antenatal diet and physical activity on maternal and fetal outcomes: Individual patient data meta-analysis and health economic evaluation
(Journal article; Peer reviewed; Research report, 2017)Abstract Background Diet- and physical activity-based interventions in pregnancy have the potential to alter maternal and child outcomes. Objectives To assess whether or not the effects of diet and lifestyle ... -
Effects of APIM-containing peptides on the regulation of the PI3K/Akt and MEK/ERK pathways
(Master thesis, 2013)PI3K/Akt and MEK/ERK pathways are important cellular signaling system which controls many vital cellular processes, including cell survival, proliferation, differentiation and migration. These pathways are often deregulated ... -
Effects of bone morphogenetic proteins, hepatocyte growthfactor and interleukin-21 in multiple myeloma
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:4, Doctoral thesis, 2006)The studies presented in this thesis answer some questions, but also raise new questions which should be explored in future studies. The bone marrow microenvironment is a complex system, and is difficult to study in vitro. ... -
Effects of Budesonide on the Intestinal Epithelium: Studies using IBD patient-derived Colonoids
(Master thesis, 2021)Bakgrunn: Tarmepitelcellene er etter hvert anerkjent som en viktig faktor i sykdomsbildet til inflammatoriske tarmsykdom (IBD). Det tradisjonelle anti-inflammatoriske steroid- legemiddelet budesonid er mye brukt i behandling ... -
Effects of cPLA2a inhibition in the MDA-MB-468 cell model system for basal-like breast cancer and/or triple negative breast cancer
(Master thesis, 2016)Basal-like breast cancer (BLBC) is a highly aggressive breast cancer sub-type and represents ~15% of all breast cancers. BLBC are often associated with early age of onset, early relapse and poor overall survival in contrast ... -
Effects of cPLA2α inhibition in the MDAMB-468 cell model system for basal-like breast cancer and/or triple negative breast cancer
(Master thesis, 2016)Basal-like breast cancer (BLBC) is a highly aggressive breast cancer sub-type and represents ~15% of all breast cancers. BLBC are often associated with early age of onset, early relapse and poor overall survival in contrast ... -
Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review
(Journal article; Peer reviewed, 2019)Background: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer. Methods: This review was conducted according to the PRISMA guidelines ... -
Effects of doxorubicin on cell death and the transcriptome in human AC16 cardiomyocytes
(Master thesis, 2022)Bakgrunn: Kreft og hjarte- og karsjukdom er leiande dødsårsaker i verda. Doxorubicin er mykje nytta som cellegift i kreftbehandling, men utvikling av kardiotoksisitet avgrensar bruken. Faktorar som bidreg til doxorubicin-indusert ... -
Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats
(Journal article; Peer reviewed, 2014)Background: A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment of super obesity. The aim of the present study was to test whether duodenal switch alone (DS) leads to ... -
Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol.
(Journal article; Peer reviewed, 2016)Introduction The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to ... -
Effects of FKBP12-degrading PROTACs on receptor-specific TGF-β signaling in multiple myeloma
(Master thesis, 2021)Abstract Background and aims: Multiple myeloma (MM) is a form of cancer caused by the proliferation of aberrant plasma cells. Myeloma cells are addicted to the MYC oncogene, and this research group has previously shown ... -
Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts
(Journal article; Peer reviewed, 2019)To address the shortcomings associated with corneal transplants, substantial efforts have been focused on developing new modalities such as xenotransplantion. Xenogeneic corneas are anatomically and biomechanically similar ... -
Effects of hexyl aminolevulinate and Amphinex based photodynamic therapy and photochemical internalization - in vitro studies using rat bladder cancer cells
(Master thesis, 2011)Photodynamic therapy (PDT) is a treatment modality which involves application of photosensitizers and their ability to accumulate selectively and damage cancer cells in presence of light. Light induced damage to cancer ... -
Effects of High Intensity Interval Training and Strenght Training on Metabolic, Cardiovascular and Hormonal Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Study
(Journal article; Peer reviewed, 2015)Background: Polycystic ovary syndrome is a common endocrinopathy in reproductive-age women, and associates with insulin resistance. Exercise is advocated in this disorder, but little knowledge exists on the optimal ... -
Effects of hypoxia/reoxygenation and miR-24-3p in human cardiomyocyte models
(Master thesis, 2020)Background: Effective cardioprotective therapies targeting the reperfusion phase of ischemia/reperfusion (I/R) injury are lacking, which remain one of the top unmet clinical needs in cardiology. MicroRNAs (miRNAs) are a ... -
Effects of lost microRNA regulation at the global and single gene level in mammalian cells
(Doctoral thesis at NTNU;2014:307, Doctoral thesis, 2014) -
Effects of overexpressing NOR-1 on cell death and cell viability in human cardiomyocytes during doxorubicin-induced stress
(Master thesis, 2021)Koronar hjertesykdom er den ledende dødsårsaken i verden, karakterisert av redusert blodforsyning til hjertet. Ubehandlet kan dette føre til en fullstendig blokkering av koronararteriene, kjent som et hjerteinfarkt. ...