Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 597-616 av 3451
-
A comparison of Generative Adversarial Networks for automated prostate cancer detection on T2-weighted MRI
(Journal article; Peer reviewed, 2023)Generative Adversarial Networks (GANs) have shown potential in medical imaging. In this study, several previously developed GANs were investigated for prostate cancer (PCa) detection on T2-weighted (T2W) magnetic resonance ... -
Comparison of Interferon-Gamma (IFNG) +874 T/A single nucleotide polymorphism in hepatitis C virus infected patients and non-infected controls in Mashhad, Iran
(Journal article; Peer reviewed, 2017)Background and Objectives: Interferon-gamma is an important cytokine, which facilitates immunity against intracellular pathogens. Several factors, including genetic variations of cytokine-producing genes have been shown ... -
Comparison of iron acquisition mechanisms and growth characteristics of Escherichia coli from bloodstream infection in patients with low and normal iron status
(Master thesis, 2019)Sepsis is a systemic inflammatory response to infection which is one of the major public health issues with significant mortality and morbidity. Bloodstream infections are infectious diseases characterised by the presence ... -
Comparison of methods to construct a genetic risk score for prediction of rheumatoid arthritis in the population-based Nord-Trøndelag Health Study, Norway
(Peer reviewed; Journal article, 2020)Objectives: To evaluate selection methods among published single-nucleotide polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) in a population-based setting. Methods: The Nord-Trøndelag ... -
Comparison of microbial community dynamics induced by distinct crude oil dispersions reveals compositional differences
(Journal article; Peer reviewed, 2018)To understand the impact of oil contamination on marine microbial communities, numerous studies have been conducted following microbial dynamics after oil spills and concerning the effects of different environmental ... -
Comparison of surgical skill acquisition by UK surgical trainees and Sierra Leonean associate clinicians in a task-sharing programme
(Journal article; Peer reviewed, 2018)Background Task‐sharing in surgery is well established, with associate clinicians performing successful surgery in many countries. Little is known about the process of surgical skill acquisition by associate clinicians, ... -
Comparison of the associations between non-traditional and traditional indices of adiposity and cardiovascular mortality: an observational study of one million person-years of follow-up
(Journal article; Peer reviewed, 2019)Background/objective The most widely used adiposity index, body mass index (BMI), is not optimal to evaluate cardiovascular (CV) risk associated with overweight and obesity. We aimed to explore the association between ... -
Comparison of three point-of-care testing devices to detect hemostatic changes in adult elective cardiac surgery: A prospective observational study
(Journal article; Peer reviewed, 2014)Background: Bleeding complications in cardiac surgery may lead to increased morbidity and mortality. Traditional blood coagulation tests are not always suitable to detect rapid changes in the patient's coagulation status. ... -
Comparson og two methods for evaluation of tumor mass in multiple myeloma
(Master thesis, 2016)Background: The size of malignant tumours are in many instances proven or thought to mirror the risk of progression and/or death. In multiple myeloma, tumour cell mass can not be directly measured as the cells do not adhere ... -
Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis
(Peer reviewed; Journal article, 2019)Background: Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections, especially spontaneous bacterial peritonitis (SBP), leading to systemic inflammation that is associated with ... -
Compensatory mechanisms activated with intermittent energy restriction: a randomized trial
(Journal article; Peer reviewed, 2017)Background & aims Strong compensatory responses, with reduced resting metabolic rate (RMR), increased exercise efficiency (ExEff) and appetite, are activated when weight loss (WL) is achieved with continuous energy ... -
A Compilation of Serum Concentrations of 12 Antipsychotic Drugs in a Therapeutic Drug Monitoring Setting
(Peer reviewed; Journal article, 2019)Background: No comprehensive collection of routine therapeutic drug monitoring data for antipsychotic drugs has been published. Methods: In this compilation, data on 12 antipsychotics are presented. The drugs included ... -
Complement activation by cholesterol crystals triggers a subsequent cytokine response
(Journal article; Peer reviewed, 2017)In the host a diverse collection of endogenous danger signals is constantly generated consisting of waste material as protein aggregates or crystalline materials that are recognized and handled by soluble pattern recognition ... -
Complement Activation in 22q11.2 Deletion Syndrome
(Peer reviewed; Journal article, 2020)The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems ... -
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome.
(Journal article; Peer reviewed, 2016) -
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
(Peer reviewed; Journal article, 2021)Background Cardiopulmonary resuscitation after cardiac arrest initiates a whole-body ischemia-reperfusion injury, which may activate the innate immune system, including the complement system. We hypothesized that complement ... -
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
(Journal article; Peer reviewed, 2022) -
A complement C3–Specific nanobody for modulation of the alternative cascade identifies the C-Terminal domain of C3b as functional in C5 convertase activity
(Peer reviewed; Journal article, 2020)The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing ... -
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
(Journal article; Peer reviewed, 2018)There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully ... -
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
(Peer reviewed; Journal article, 2020)Inflammation is centrally involved in the development of cardiac hypertrophy and the processes of remodelling. The complement system and Toll-like receptor (TLR) family, two upstream arms of the innate immune system, have ...