Blar i Institutt for klinisk og molekylær medisin på tittel
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A transgenic minipig model of Huntington’s disease shows early signs of behavioral and molecular pathologies
(Journal article; Peer reviewed, 2018)Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans ... -
A translational medicine approach to hypertensive nephropathy: Prevalence, diagnosis, and pathophysiology
(Doctoral theses at NTNU;2018:400, Doctoral thesis, 2018)NORSK SAMMENDRAG Translasjonsmedisinske studier av hypertensiv nefropati: Prevalens, diagnose og patofysiologi Kronisk nyresjukdom defineres som nedsatt nyrefunksjon (estimert glomerulær filtrasjonsrate (eGFR) <60 ... -
A two-step site and mRNA-level model for predicting microRNA targets
(Journal article; Peer reviewed, 2010)Background: Despite experiments showing that the number of microRNA (miRNA) target sites is critical for miRNA targeting, most existing methods focus on identifying individual miRNA target sites and do not model contributions ... -
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair
(Journal article; Peer reviewed, 2017)DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical ... -
A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study
(Journal article; Peer reviewed, 2018)Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ... -
abc4pwm: affinity based clustering for position weight matrices in applications of DNA sequence analysis
(Peer reviewed; Journal article, 2022)Background Transcription factor (TF) binding motifs are identified by high throughput sequencing technologies as means to capture Protein-DNA interactions. These motifs are often represented by consensus sequences in form ... -
Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls
(Peer reviewed; Journal article, 2022)Preterm birth at very low birth weight (VLBW, < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could ... -
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
(Peer reviewed; Journal article, 2020)An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function ... -
Absorption and pharmacokinetics of bupivacaine after bilateral topical administration in tonsillar fossae for posttonsillectomy pain relief
(Journal article; Peer reviewed, 2024)No previous studies have investigated the systemic absorption of bupivacaine when used topically for posttonsillectomy pain. The present study was undertaken to investigate the pharmacokinetics of bupivacaine after ... -
Academic detailing as a method of continuing medical education
(Journal article; Peer reviewed, 2019)Introduction: Academic detailing is an interactive educational outreach to prescribers to present unbiased, non-commercial, evidence-based information, mostly about medications, with the goal of improving patient care. ... -
Academic detailing as a method to improve general practitioners’ drug prescribing in type 2 diabetes: evaluation of changes in prescribing
(Peer reviewed; Journal article, 2023)Objective To investigate the effect of an academic detailing intervention on the utilisation of type 2 diabetes medication among general practitioners. Design We developed an academic detailing campaign based on the ... -
Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin
(Peer reviewed; Journal article, 2020)Background and aims The alcohol withdrawal syndrome increases autonomic activation and stress in patients during detoxification, leading to alterations in motor activity and sleep irregularities. Intranasal oxytocin has ... -
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli
(Peer reviewed; Journal article, 2021)Cell-penetrating peptides (CPPs) are increasingly used for cellular drug delivery in both pro- and eukaryotic cells, and oligoarginines have attracted special attention. How arginine-rich CPPs translocate across the cell ... -
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
(Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study
(Peer reviewed; Journal article, 2021)Background: Every year, millions of people are hospitalized and thousands die from influenza A virus (FLUAV) infection. Most cases of hospitalizations and death occur among the elderly. Many of these elderly patients are ... -
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
(Journal article; Peer reviewed, 2015)Background: Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated ... -
Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors
(Peer reviewed; Journal article, 2020)Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ... -
Acute and potentially persistent effects of scuba diving on the blood transcriptome of experienced divers
(Journal article; Peer reviewed, 2013)During scuba diving, the circulatory system is stressed by an elevated partial pressure of oxygen while the diver is submerged and by decompression-induced gas bubbles on ascent to the surface. This diving-induced stress ... -
Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial
(Journal article; Peer reviewed, 2019)Background: Fish protein hydrolysates are suggested to contain bioactive sequences capable of affecting metabolic pathways involved in the regulation of glucose metabolism and body weight when consumed in low doses. ... -
Acute effects of strength and endurance training on bone turnover markers in young adults and elderly men
(Peer reviewed; Journal article, 2022)Context: Exercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain. Objective: To assess the acute effects of two ...