Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 453-472 of 3554
-
Causal role of human bocavirus 1 in respiratory tract infections in children
(Doctoral theses at NTNU;2016:257, Doctoral thesis, 2016)Norsk sammendrag: Humant bocavirus 1 og luftveisinfeksjoner hos barn Humant bocavirus 1 (HBoV1) ble oppdaget i 2005 i luftveisprøver fra barn med luftveisinfeksjon. Det tilhører familien Parvoviridae, og var det første ... -
CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination
(Peer reviewed; Journal article, 2019)Motivation Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key task is the formalization of such information in models ... -
Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study
(Journal article; Peer reviewed, 2019)Background Testicular germ cell tumor (TGCT) patients and survivors have excess mortality compared to the general male population, but relative survival (RS) has been scarcely studied. We investigated causes of excess ... -
CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis
(Peer reviewed; Journal article, 2022)CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and ... -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
(Journal article, 2015)Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by ... -
CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
(Peer reviewed; Journal article, 2020)Background During sepsis, gram‐negative bacteria induce robust inflammation primarily via lipopolysacharride (LPS) signaling through TLR4, a process that involves the glycosylphosphatidylinositol (GPI)‐anchored receptor ... -
CD36 - a plausible modifier of disease phenotype in familial adenomatous polyposis
(Journal article; Peer reviewed, 2018)Background: Familial adenomatous polyposis (FAP) is a well characterised genetic predisposition to early onset colorectal cancer (CRC) that is characterised by polyposis of the colon and rectum. Animal models have consistently ... -
CD36 Defines Primitive Chronic Myeloid Leukemia Cells Less Responsive To Imatinib But Vulnerable To Antibody-Based Therapeutic Targeting
(Journal article; Peer reviewed, 2018)Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the ... -
Cell-type specificity of ChIP-predicted transcription factor binding sites
(Journal article; Peer reviewed, 2012)Background Context-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed by high-throughput sequencing ... -
Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV Infection
(Journal article; Peer reviewed, 2019)Human metapneumovirus (HMPV) may cause severe respiratory disease. The early innate immune response to viruses like HMPV is characterized by induction of antiviral interferons (IFNs) and proinflammatory immune mediators ... -
Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
(Master thesis, 2020)Nanopartikler kan forbedre effekten og biodistribusjonen, og redusere toksisiteten til allerede eksisterende legemidler ved å innkapsle dem. I tillegg, nanopartikler kan legge til rett for leveringen av legemidler som er ... -
CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trial
(Peer reviewed; Journal article, 2022)Background The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in ... -
The central role of gastrin in gastric cancer
(Peer reviewed; Journal article, 2023)The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ... -
Centralization of primary surgery for ovarian cancer: Feasibility and impact on survival
(Dissertations at the Faculty of Medicine, 0805-7680; 223, Doctoral thesis, 2003)The general aim of the thesis was to gain more epidemiological knowledge of ovarian cancer by studying the feasibility and effect of centralized primary surgery on survival for ovarian cancer. The individual papers had the ... -
Centralizing a national pancreatoduodenectomy service: striking the right balance
(Peer reviewed; Journal article, 2020)Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ... -
Cerebral palsy in children born after assisted reproductive technology in Norway: Risk, prevalence, and clinical characteristics
(Peer reviewed; Journal article, 2023)Introduction The aim was to investigate the risk, prevalence, and clinical characteristics of cerebral palsy among children born after assisted reproductive technology (ART) in Norway. Material and methods All ... -
Cerebral palsy in extremely preterm infants
(Journal article; Peer reviewed, 2018)BACKGROUND AND OBJECTIVES: The risk of cerebral palsy (CP) is high in preterm infants and is often accompanied by additional neurodevelopmental comorbidities. The present study describes lifetime prevalence of CP in a ... -
Cerebral palsy in Norway – subtypes, severity and risk factors
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:115, Doctoral thesis, 2011)Cerebral palsy (CP) is still the most common cause of chronic motor disability in hildhood. Until now, there has not been any previous national study of the anorama of subtypes, severity or risk factors among children with ... -
Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study
(Peer reviewed; Journal article, 2022)Central nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin ... -
Challenges in implementing circulating tumor DNA analyses in lung cancer research
(Doctoral theses at NTNU;2023:327, Doctoral thesis, 2023)Lung cancer is the leading cause of cancer-related deaths worldwide, including Norway. This study focused on non-small cell lung cancer (NSCLC), the most common subtype, and aimed to enhance the classification of NSCLC ...