Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 449-468 of 3588
-
Case Report: Limbic encephalitis following treatment with durvalumab for small-cell lung cancer
(Peer reviewed; Journal article, 2023)Background: Durvalumab is an immune checkpoint Inhibitor (ICIs) that is used in the treatment of malignant tumors, such as lung cancer and melanoma. ICIs are associated with immune-related adverse events including autoimmune ... -
Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation
(Peer reviewed; Journal article, 2023)During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is ... -
Caspase-8 regulates the expression of pro- and anti-inflammatory cytokines in human bone marrow-derived mesenchymal stromal cells
(Journal article; Peer reviewed, 2016)Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their immunosuppressive properties. How these cells respond to chronic inflammatory ... -
Castration-resistant prostate cancer cells are dependent on the high activity of CDK7
(Journal article; Peer reviewed, 2022) -
Catastrophic expenditure and impoverishment after caesarean section in Sierra Leone: An evaluation of the free health care initiative
(Peer reviewed; Journal article, 2021)Background Utilizing surgical services, including caesarean sections, can result in catastrophic expenditure and impoverishment. In 2010, Sierra Leone introduced the Free Health Care Initiative (FHCI), a national financial ... -
Causal role of human bocavirus 1 in respiratory tract infections in children
(Doctoral theses at NTNU;2016:257, Doctoral thesis, 2016)Norsk sammendrag: Humant bocavirus 1 og luftveisinfeksjoner hos barn Humant bocavirus 1 (HBoV1) ble oppdaget i 2005 i luftveisprøver fra barn med luftveisinfeksjon. Det tilhører familien Parvoviridae, og var det første ... -
CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination
(Peer reviewed; Journal article, 2019)Motivation Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key task is the formalization of such information in models ... -
Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study
(Journal article; Peer reviewed, 2019)Background Testicular germ cell tumor (TGCT) patients and survivors have excess mortality compared to the general male population, but relative survival (RS) has been scarcely studied. We investigated causes of excess ... -
CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis
(Peer reviewed; Journal article, 2022)CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and ... -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
(Journal article, 2015)Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by ... -
CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
(Peer reviewed; Journal article, 2020)Background During sepsis, gram‐negative bacteria induce robust inflammation primarily via lipopolysacharride (LPS) signaling through TLR4, a process that involves the glycosylphosphatidylinositol (GPI)‐anchored receptor ... -
CD36 - a plausible modifier of disease phenotype in familial adenomatous polyposis
(Journal article; Peer reviewed, 2018)Background: Familial adenomatous polyposis (FAP) is a well characterised genetic predisposition to early onset colorectal cancer (CRC) that is characterised by polyposis of the colon and rectum. Animal models have consistently ... -
CD36 Defines Primitive Chronic Myeloid Leukemia Cells Less Responsive To Imatinib But Vulnerable To Antibody-Based Therapeutic Targeting
(Journal article; Peer reviewed, 2018)Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the ... -
Cell-type specificity of ChIP-predicted transcription factor binding sites
(Journal article; Peer reviewed, 2012)Background Context-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed by high-throughput sequencing ... -
Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV Infection
(Journal article; Peer reviewed, 2019)Human metapneumovirus (HMPV) may cause severe respiratory disease. The early innate immune response to viruses like HMPV is characterized by induction of antiviral interferons (IFNs) and proinflammatory immune mediators ... -
Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
(Master thesis, 2020)Nanopartikler kan forbedre effekten og biodistribusjonen, og redusere toksisiteten til allerede eksisterende legemidler ved å innkapsle dem. I tillegg, nanopartikler kan legge til rett for leveringen av legemidler som er ... -
CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trial
(Peer reviewed; Journal article, 2022)Background The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in ... -
The central role of gastrin in gastric cancer
(Peer reviewed; Journal article, 2023)The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ... -
Centralization of primary surgery for ovarian cancer: Feasibility and impact on survival
(Dissertations at the Faculty of Medicine, 0805-7680; 223, Doctoral thesis, 2003)The general aim of the thesis was to gain more epidemiological knowledge of ovarian cancer by studying the feasibility and effect of centralized primary surgery on survival for ovarian cancer. The individual papers had the ... -
Centralizing a national pancreatoduodenectomy service: striking the right balance
(Peer reviewed; Journal article, 2020)Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ...