Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 3308-3327 av 3587
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The transcriptional and post-transcriptional regulation in cancer
(Master thesis, 2019)Head and neck squamous cell carcinomas are a collection of tumors that arise from mucosal cells in the oral cavity and the upper airway and food passages. Despite their common mucosal origin, the group of HNSCCs is rather ... -
The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding
(Journal article; Peer reviewed, 2012)Background: Chromatin immunoprecipitation combined with high-throughput sequencing (ChIP-Seq) is the most frequently used method to identify the binding sites of transcription factors. Active binding sites can be seen ... -
The undifferentiated carcinoma that became a melanoma: Re-biopsy of a cancer of an unknown primary site: a case report.
(Journal article; Peer reviewed, 2017)Background Cancer of unknown primary site is still a demanding condition as it is per definition metastatic, with heterogeneous biological behavior, and it is often resistant to therapy. Cancer of unknown primary site ... -
The use of anticholinergic antiparkinson agents in Norway: Epidemiology, toxicology and clinical implications
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:212, Doctoral thesis, 2010)This thesis is based on two fundamental questions: Which patients are currently using anticholinergic antiparkinson drugs? Does it matter which anticholinergic antiparkinson drug they are using? These questions were further ... -
THE USE OF LIQUID-BASED CYTOLOGY IN DIAGNOSIS OF BASAL CELL CARCINOMA AND ACTINIC KERATOSIST - The CYT-BAK study
(Master thesis, 2015)Background: Ahead of new non-invasive treatments of non-melanoma skin cancer, cytology has proven beneficial and may become the diagnostic method of choice as it results in little tissue disfiguration and thus a superior ... -
The WE-Study: does botulinum toxin A make walking easier in children with cerebral palsy?: Study protocol for a randomized controlled trial
(Journal article; Peer reviewed, 2017)Background Intramuscular injections of botulinum toxin A (BoNT-A) have been a cornerstone in the treatment of spasticity for the last 20 years. In Norway, the treatment is now offered to two out of three children with ... -
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
(Journal article; Peer reviewed, 2016)Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses ... -
Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience
(Peer reviewed; Journal article, 2023)Despite several targeted antiviral drugs against SARS-CoV-2 currently being available, the application of type I interferons (IFNs) still deserves attention as an alternative antiviral strategy. This study aimed to assess ... -
Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial
(Journal article; Peer reviewed, 2019)OBJECTIVE: To evaluate the neuroprotective effect of therapeutic hypothermia (TH) induced by phase changing material (PCM) on MRI biomarkers in infants with hypoxic-ischaemic encephalopathy (HIE) in a low-resource setting. ... -
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
(Peer reviewed; Journal article, 2021)The complement system was discovered at the end of the 19th century as a heat-labile plasma component that “complemented” the antibodies in killing microbes, hence the name “complement.” Complement is also part of the ... -
There are 4, not 7, cardinal movements in labor
(Journal article; Peer reviewed, 2021)The mechanics of labor describe the forces required for fetal descent, and the movements that the fetus must perform to overcome the resistance met by the maternal bony pelvis and soft tissue. The fetus negotiates the birth ... -
Thinking strategies used by registered nurses during drug administration in nursing homes — An observational study
(Journal article; Peer reviewed, 2023)Aim: To explore registered nurses' thinking strategies during the drug administration process in nursing homes. Design: An exploratory qualitative design. Methods: Eight registered nurses, one male and seven female, in ... -
Thoracic radiotherapy in limited disease small cell lung cancer
(Doctoral theses at NTNU;2017:7, Doctoral thesis, 2017)Norsk sammendrag: Lungekreft er den tredje hyppigste kreftformen, og den ledende årsaken til kreftrelaterte dødsfall. Småcellet lungekreft (SCLC) er den mest aggressive av to hovedtyper lungekreft, og forekommer nesten ... -
Thoracic Radiotherapy in Limited-Stage SCLC—a Population-Based Study of Patterns of Care in Norway From 2000 Until 2018
(Peer reviewed; Journal article, 2022)Introduction Twice-daily (BID) thoracic radiotherapy (TRT) of 45 Gy per 30 fractions is recommended for limited-stage (LS) SCLC, but most patients are treated with once-daily (OD) schedules owing to toxicity concerns ... -
Three groups of suspects in police-reported rape cases: First-time suspects, recidivists and unidentified suspects. A comparative study
(Peer reviewed; Journal article, 2019)Background Previous studies show that reported suspects in adult rape cases often have a criminal record, and that many are rape recidivists. Annual numbers of police reported rapes have dramatically increased but the ... -
Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood
(Peer reviewed; Journal article, 2022)Thrombin plays a central role in thromboinflammatory responses, but its activity is blocked in the common ex vivo human whole blood models, making an ex vivo study of thrombin effects on thromboinflammatory responses ... -
Thromboembolic Events During Treatment with Cisplatin-based Chemotherapy in Metastatic Testicular Germ-cell Cancer 2000–2014: A Population-based Cohort Study
(Peer reviewed; Journal article, 2021)Background Cisplatin-based chemotherapy (CBCT) in testicular cancer (TC) is associated with elevated venous thromboembolism (VTE) risk, but trials evaluating the safety and efficacy of thromboprophylaxis are lacking. ... -
Thromboinflammation - Exploring the role of cholesterol crystals and toll-like receptor ligands (2/6, 7, 8) in monocyte tissue factor (TF) expression and inflammation
(Master thesis, 2021)Abstract will be available on 2024-07-03 -
Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
(Peer reviewed; Journal article, 2023)Background: Pancreas transplant alone (PTA) recipients are more affected by pancreas graft thrombosis, and graft loss compared to simultaneous pancreas-kidney (SPK) recipients. The pathophysiology is unknown, but an increased ... -
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin
(Peer reviewed; Journal article, 2022)Objective: Polycystic ovary syndrome (PCOS) and hypothyroidism are related conditions, and both are associated with adverse pregnancy outcomes. Knowledge is lacking about the complex interaction between thyroid status and ...