Blar i Institutt for klinisk og molekylær medisin på tittel
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The alternative complement pathway is dysregulated in patients with chronic heart failure
(Journal article; Peer reviewed, 2017)The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; ... -
The anti-apoptotic protein survivin can improve the prognostication of meningioma patients
(Journal article; Peer reviewed, 2017)Background The 2016 WHO histopathological grading includes a substantial within-variation in recurrence risk, and is thus insufficient to predict prognosis after initial surgery of patients suffering from meningiomas. ... -
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia
(Journal article; Peer reviewed, 2016)Objective: Preeclampsia is a complex heterogeneous disease commonly defined by newonset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later ... -
The APIM-peptide, a novel anti-cancer drug targeting the stress-related roles of PCNA
(Doctoral theses at NTNU;2019:186, Doctoral thesis, 2019) -
The applicability of a weight loss grading system in cancer cachexia: a longitudinal analysis
(Journal article; Peer reviewed, 2017)Background A body mass index (BMI) adjusted weight loss grading system (WLGS) is related to survival in patients with cancer. The aim of this study was to examine the applicability of the WLGS by confirming its prognostic ... -
The Artificial Pancreas: A Dynamic Challenge
(Journal article; Peer reviewed, 2016)In patients with diabetes mellitus type 1, the pancreatic insulin production ceases, causing raise in blood glucose level (BGL) and potentially severe long-term complications. The “holy grail” of diabetes treatment is the ... -
The association between the clinical diversity of psoriasis and depressive symptoms: the HUNT Study, Norway
(Journal article; Peer reviewed, 2017)Background While a number of observational hospital‐based studies have reported an association between psoriasis and depression, less is known about the clinical diversity of psoriasis and depressive symptoms. Objective To ... -
The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and negative subjects: A post-hoc analysis of the ORIGIN trial
(Journal article; Peer reviewed, 2018)We compared cardiovascular and other outcomes in patients with dysglycaemia with or without anti‐glutamic acid dehydrogenase (GAD) antibodies participating in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) ... -
The Association of Tissue Steroid Hormone Levels with Body Mass Index and Endocrine Treatment Resistance in Women with Estrogen Receptor-positive Breast Cancer
(Master thesis, 2022)Abstract will be available on 2023-07-01 -
The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway
(Journal article; Peer reviewed, 2018)Background Sedentary behavior is thought to pose different risks to those attributable to physical inactivity. However, few studies have examined the association between physical activity and sitting time with cancer ... -
The biological importance of gastrin-induced genes, NR4A2 and SIK1
(Master thesis, 2011) -
The Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Norwegian Children
(Journal article; Peer reviewed, 2017)Background. The burden of severe human metapneumovirus (HMPV) respiratory tract infections (RTIs) in European children has not been clarified. We assessed HMPV in Norwegian children and compared hospitalization rates for ... -
The C-terminus of AID masks the N-terminal bipartite NLS and prevents nuclear import
(Master thesis, 2009) -
The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study
(Journal article; Peer reviewed, 2013)Cigarette smoking is strongly associated with mental illness but the causal direction of the association is uncertain. We investigated the causal relationship between smoking and symptoms of anxiety and depression in the ... -
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
(Journal article; Peer reviewed, 2017)Objective Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be ... -
The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: Recommendations from the European Myeloma Network
(Journal article; Peer reviewed, 2014)Monoclonal gammopathy of undetermined significance is one of the most common pre-malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are precursor conditions of multiple myeloma; light-chain ... -
The co-use of conventional drugs and herbs among patients in Norwegian general practice: a cross-sectional study
(Journal article; Peer reviewed, 2013)Background Different patient groups are known to use herbal remedies and conventional drugs concomitantly (co-use). This poses a potential risk of herb-drug interaction through altering the drug’s pharmacokinetics or ... -
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
(Peer reviewed; Journal article, 2015)Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier ... -
The contribution of different uracil-DNA glycosylases to removal of uracil from DNA in different mouse organs - the significance of sequence context and proliferative status
(Master thesis, 2014)Uracil is a non-canonical base in DNA that can arise through misincorporation of dUMP instead of dTMP during replication or from cytosine deamination. Uracil in DNA can be removed by the four different DNA glycosylases ... -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
(Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ...