Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2011-2030 av 3451
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Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
(Journal article; Peer reviewed, 2015)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ... -
Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts
(Peer reviewed; Journal article, 2022)Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ... -
Metabolic response to everolimus in patient-derived triple negative breast cancer xenografts
(Journal article; Peer reviewed, 2017)Patients with triple-negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the ... -
Metabolic syndrome and esophageal and gastric cancer
(Journal article; Peer reviewed, 2015)Background The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. Methods This was a large nationwide cohort study based on data from 11 prospective population-based cohorts ... -
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
(Journal article, 2017)The mitochondrial DNA (mtDNA) resides in the vicinity of energy-rich reactions. Thus, chemical modifications of mtDNA might mirror mitochondrial processes and could serve as biomarkers of metabolic processes in the ... -
Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment
(Journal article; Peer reviewed, 2018)Background Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment ... -
Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry
(Peer reviewed; Journal article, 2019)New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ... -
Metabolomic biomarkers in serum and urine in women with preeclampsia
(Journal article, 2014)Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
(Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomic profiling reveals distinct and mutual effects of diet and inflammation in shaping systemic metabolism in LDLR<sup>−/−</sup> mice
(Journal article; Peer reviewed, 2020) -
Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients
(Journal article; Peer reviewed, 2017)Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
(Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study
(Peer reviewed; Journal article, 2020)PURPOSE It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. ... -
Metacognitive Strategy Training Versus Psychoeducation for Improving Fatigue in Children and Adolescents With Acquired Brain Injuries: A Randomized Controlled Trial
(Journal article; Peer reviewed, 2022) -
Metastatic Cancerous Intestinal Epithelial Cells express Toll-like receptor 3 and release RANTES/CCL5 and IP-10/CXCL10 in response to Double-stranded RNA
(Master thesis, 2011)Toll-like receptors (TLR)s are important for mounting an inflammatory response against invading microorganisms by recognizing pathogen-associated molecular patterns (PAMP)s, which are rare or absent in vertebrates. TLRs ... -
Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study
(Peer reviewed; Journal article, 2022)Background Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ... -
Metformin in pregnancy and long-term health of children of women with polycystic ovary syndrome
(Doctoral theses at NTNU;2019:187, Doctoral thesis, 2019)Metformin i svangerskap og langtidshelse hos barn av mødre med polycystisk ovariesyndrom (PCOS) Polycystisk ovariesyndrom (PCOS) er en vanlig tilstand hos kvinner i fertil alder, med en prevalens på rundt 15%. PCOS gir ... -
Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis
(Peer reviewed; Journal article, 2020)Introduction: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in ... -
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment
(Peer reviewed; Journal article, 2023)The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and ... -
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment
(Peer reviewed; Journal article, 2023)The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and ...